Does Cardiac Morphology Predict Plasma Brain Natriuretic Peptide Levels in Adolescent Athletes?
This is an author-produced, peer-reviewed version of this article. The final, definitive version of this document can be found online at Clinical Journal of Sport Medicine, published by Lippincott, Williams & Wilkins. Copyright restrictions may apply. doi: 10.1097/JSM.0b013e318194f0d6
Objective: The purpose of this study was to establish the relationship of plasma levels of brain natriuretic peptide (BNP) to physiological parameters and cardiac morphological characteristics in a population of young athletes. Our hypothesis is that physiological and cardiac morphological characteristics do not predict BNP levels in adolescent athletes.
Design: Observational study
Setting: Outpatient hospital
Patients: 30 healthy male adolescent high school football players (16.0 +/- 1.1 yrs)
Intervention: Physical exam, electrocardiography, plasma BNP measurement by rapid fluorescent immunoassay, and limited echocardiography Main Outcome Measure Null hypothesis: physiologic parameters and cardiac morphology do not predict plasma BNP levels in healthy adolescent football players. Significance level set at p < 0.05.
Results: Plasma BNP for this population was 11.9 +/- 10.2 pg•mlˉ¹. There was no correlation between BNP and mean arterial pressure (r = -0.09, p = 0.64), BMI (r = 0.11, p = 0.57), interventricular septal thickness (r = -0.15, p = 0.44), left ventricular wall thickness (r = 0.00, p = 0.99), relative wall thickness (r = -0.04, p = 0.84), left ventricular mass (r = 0.05, p = 0.79), or left ventricular mass index (r = 0.11, p = 0.55).
Conclusion: Plasma BNP levels in healthy adolescent athletes have no correlation to BMI or LV mass, even when corrected for body surface area.
Kurt J. Nilsson, Michael S. Womack, Ronald Pfeiffer, Chad Harris, and Mark Debeliso. "Does Cardiac Morphology Predict Plasma Brain Natriuretic Peptide Levels in Adolescent Athletes?" Clinical Journal of Sports Medicine 19.2 (2009): 130-133.
Available at: http://works.bepress.com/rpfeiffer/2