Articles

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Butylated Hydroxytoluene Chemoprevention of Aflatoxicosis - Effects on Aflatoxin B1 Bioavailability, Hepatic DNA Adduct Formation, and Biliary Excretion (with J. A. Guarisco and J. O. Hall), Food and Chemical Toxicology (2008)

The extreme sensitivity of turkeys to aflatoxin B1 (AFB1) is associated with efficient hepatic cytochrome...

 

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Mechanisms of Butylated Hydroxytoluene Chemoprevention of Aflatoxicosis - Inhibition of Aflatoxin B1 Metabolism (with John A. Guarisco and Jefferey O. Hall), Toxicology and Applied Pharmacology (2008)

Chemoprevention of toxicoses and/or cancer through the use of nutrients or pharmacologic compounds is the...

 

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Effects of PM2.5 Collected from Cache Valley Utah on Genes Associated with the Inflammatory Response in Human Lung Cells (with Todd L. Watterson, Jared Sorenson, and Randy Martin), Journal of Toxicology and Environmental Health, Part A: Current Issues (2007)

In January 2004, the normally picturesque Cache Valley in northern Utah made national headlines with...

 

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Aflatoxin B1 Alters the Expression of P53 in Cytochrome P450-Expressing Human Lung Cells (with Terry R. Van Vleet, Todd L. Watterson, and Patrick J. Klein), Toxicological Sciences (2006)

Aflatoxin B1 (AFB1) is a potent dietary hepatocarcinogen in animals and probably in humans. Mutations...

 

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Molecular cloning and expression of a novel cytochrome P450 from turkey liver with aflatoxin B1 metabolizing activity (with Shirley S. M. Yip), Chemical Research in Toxicology (2006)

Cytochromes P450 are members of a superfamily of oxidative hemoprotein enzymes that metabolize a variety...

 

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Molecular Cloning and Expression of a Novel Cytochrome P450 from Turkey Liver with Aflatoxin B1 Oxidizing Activity (with Shirley S. S. M. Yip), Chemical Research in Toxicology (2006)

Cytochromes P450 are members of a superfamily of oxidative hemoprotein enzymes that metabolize a variety...

 

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Chemoprevention of Aflatoxicosis in Poultry by Dietary Butylated Hydroxytoluene (with John A. Guarisco, Patrick J. Klein, and Jeffery O. Hall), Animal Feed Science and Technology (2005)

Turkeys are among the most sensitive species to the toxic effects of the mycotoxin aflatoxin...

 

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DNA Cross-Linking by Dehydromonocrotaline Lacks Apparent Base Sequence Preference (with W. Kurt Rieben), Toxicological Sciences (2004)

Pyrrolizidine alkaloids (PAs) are ubiquitous plant toxins, many of which, upon oxidation by hepatic mixed-function...

 

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Butylated Hydroxy Toluene Chemoprotection (with P. J. Klein and Jeffery O. Hall), Toxicology and Applied Pharmacology (2003)
 

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Butylated Hydroxytoluene Chemoprotection: Response to Williams (with Patrick J. Klein and Jeffery O. Hall), Toxicology and Applied Pharmacology (2003)

Letter to the Editor.

 

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Effects of Dietary Butylated Hydroxytoluene on Aflatoxin B1-Relevant Metabolic Enzymes in Turkeys (with P. J. Klein, T. R. Van Vleet, and J. O. Hall), Food and Chemical Toxicology (2003)

We have shown previously that the extreme sensitivity of turkeys to aflatoxin B1 (AFB1) is...

 

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Biochemical Factors Underlying the Age-Related Sensitivity of Turkeys to Aflatoxin B1 (with Patrick J. Klein, Terry R. Van Vleet, and Jeffery O. Hall), Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology (2002)

Poultry are some of the most sensitive species to the toxic effects of aflatoxin B1...

 

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Comparative Aflatoxin B1 Activation and Cytotoxicity in Human Bronchial Cells Expressing Cytochromes P450 1A2 and 3A4 (with Terry R. Van Vleet and Katherine Mace), Cancer Research (2002)

Some epidemiological evidence suggests a link between the inhalation of aflatoxin B1 (AFB1)-contaminated grain dusts...

 

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Dietary Butylated Hydroxytoluene Protects Against Aflatoxicosis in Turkeys (with Patrick J. Klein, Terry R. Van Vleet, and Jeffery O. Hall), Toxicology and Applied Pharmacology (2002)

Turkeys are among the most sensitive species to the toxic effects of the mycotoxin aflatoxin...

 

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Metabolism and Cytotoxicity of Aflatoxin B1 in Cytochrome P-450-Expressing Human Lung Cells (with Terry R. Van Vleet and Patrick J. Klein), Journal of Toxicology and Environmental Health, Part A: Current Issues (2002)

The mycotoxin aflatoxin B 1 (AFB 1 ) is a hepatocarcinogen in many animal models...

 

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Inhibitition of Human Cytochrome P450 2E1 by Nicotine, Cotinine, and Aqueous Cigarette Tar Extract in Vitro (with Terry R. Van Vleet and David W. Bombick), Toxicological Sciences (2001)

Cigarette smoke is a complex mixture containing, among other chemicals, pyridine alkaloids and N-nitrosamines. Carcinogenic...

 

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Metabolism of Aflatoxin B1 by Normal Human Bronchial Epithelial Cells (with Terry R. Van Vleet and Patrick J. Klein), Journal of Toxicology and Environmental Health (2001)

Aflatoxin B1 (AFB1) is a potent hepatocarcinogen in animal models and a suspected carcinogen in...

 

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Biochemical Basis for the Extreme Sensitivity of Turkeys to Aflatoxin B1 (with Patrick J. Klein, Jack N. Kelly, and Robert Buckner), Toxicology and Applied Pharmacology (2000)

Poultry are the most susceptible food animal species to the toxic effects of the mycotoxin...

 

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Comparative DNA Cross-Linking by Activated Pyrrolizidine Alkaloids (with H. Y. Kim, F. R. Stermitz, and J. K. Li), Food and Chemical Toxicology (1999)

The toxicity and bioactivity of pyrrolizidine alkaloids (PAs), common constituents of hundreds of plant species,...

 

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Pyrrolizidine Alkaloids Cross-Link DNA with Actin (with Gail L. Drew and Frank R. Stermitz), Toxicology and Applied Pharmacology (1999)

Pyrrolizidine alkaloids (PAs) are toxic constituents of hundreds of plant species, some of which people...

 

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Pyrrolizidine Alkaloids Plants, Metabolism and Toxicity (with B. L. Stegelmeier, J. A. Edgar, S. M. Colegate, D. L. Gardner, T. K. Schoch, and R. J. Molyneux), Journal of Natural Toxins (1999)

More than 350 PAs have been identified in over 6,000 plants in the Boraginaceae, Compositae,...

 

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Aflatoxin B1 Activation in Human Lung (with Jack D. Kelly, David L. Eaton, and F. Peter Guengerich), Toxicology and Applied Pharmacology (1997)

Inhalation exposure to the carcinogen aflatoxin B1(AFB1) in certain occupations is considerable. Because circumstantial epidemiological...

 

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Comparative Activation of Aflatoxin B1 by Mammlian Pulmonary Tissues (with R. Wayne Ball and J. Michael Huie), Toxicology Letters (1995)

Occupational exposures to respirable dusts contaminated with the mycotoxin aflatoxin b1 (AFB1) have been associated...

 

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Biological Action of Mycotoxins, Journal of Dairy Science (1993)

Mycotoxins are ubiquitous, mold-produced toxins that contaminate a wide variety of foods and feeds. Ingestion...

 

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Pharmacokinetics of the Antiviral Agent Carbocyclic 3-Deazaadenosine (with J. M. Huie, R. P. Sharma, and J. W. Higgins), Drug Metabolism and Disposition (1993)

The pharmacokinetics of carbocyclic 3-deazaadenosine (Cc3Ado), a competitive inhibitor of S-adenosyl-L-homocysteine hydrolase and novel antiviral...

 

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Structural Influences on Pyrrolizidine Alkaloid Induced Cytopathology (with H. Y. Kim, F. R. Stermitz, D. W. Wilson, and D. Taylor), Toxicology and Applied Pharmacology (1993)

Pyrrolizidine alkaloids (PAs), which are common constituents of hundreds of plant species around the world,...

 

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Pharmacokinetics of Intratracheally-Administered Aflatoxin B1 (with J. M. Huie, R. W. Ball, R. P. Sharma, and D. W. Wilson), Toxicology and Applied Pharmacology (1991)

High concentrations of the carcinogen aflatoxin B1 (AFB1) are commonly found in respirable, airborne grain...

 

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Comparative Action of Aflatoxin B1 in Mammalian Airway Epithelium (with Dennis W. Wilson and R. Wayne Ball), Cancer Research (1990)

Aflatoxin B1 (AFB1) is thought to be an occupational risk factor for airway carcinogenesis where...

 

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Comparative Formation and Removal of Aflatoxin B1-DNA Adducts in Cultured Mammalian Tracheal Epithelium (with R. Wayne Ball and Dennis W. Wilson), Cancer Research (1990)

Aflatoxin B1 (AFB1) DNA binding, adduct formation, and AFB1-DNA adduct repair were studied in tracheal...

 

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Importance of Hydroxyl Radical in the Vanadium-Stimulated Oxidation of NADH (with R. J. Keller, R. P. Sharma, T. A. Grover, and L. H. Piette), Free Radical Biology & Medicine (1989)

Vanadium compounds are known to stimulate the oxidation of NAD(P)H, but the mechanism remains unclear....

 

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Oxidation of NADH by Vanadium in the Presence of Thiols (with R. J. Keller, R. P. Sharma, T. A. Grover, and L. H. Piette), Archives of Biochemistry and Biophysics (1989)

The nonenzymatic oxidation of NADH was studied spectrophotometrically in the presence of two vanadium compounds,...

 

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Aflatoxin B1 Carcinogenesis and its Relationship to DNA Adduct Formation and Adduct Persistence in Sensitive and Resistant Salmonid Fish (with G. S. Bailey, D. E. Williams, J. S. Wicox, P. M. Loveland, and J. D. Hendricks), Carcinogenesis (1988)

Rainbow trout (Salmo gairdneri)and coho salmon (Oncorhyn-chus kisutch) were exposed to aflatoxin B1(AFB1) either by...

 

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Effects of Repeated Doses of Aspartame on Serotonin and its Metabolite in Various Regions of the Mouse Brain (with R. P. Sharma), Food and Chemical Toxicology (1987)

Following a finding that single doses (approximating to average intakes and to potential ‘over-use’) of...

 

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Vanadate-Dependent Oxidation of Pyridine Nucleotides in Rat Liver Microsomal Membranes (with D. P. Briskin, R. J. Keller, W. R. Thornley, and R. P. Sharma), Archives of Biochemistry and Biophysics (1987)

An enzymatic Na3VO4-dependent system for the oxidation of reduced pyridine nucleotides in purified rat liver...

 

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Metabolism of Aflatoxin B1 in the Upper Airways of the Rabbit: The Role of the Non-Ciliated Tracheal Epithelial Cell (with D. W. Wilson, D. P. H. Hsieh, C. G. Plopper, and C. J. Serabjit-Singh), Cancer Research (1986)

Short-term tracheal explant cultures from the rabbit were used to study the metabolism of the...

 

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Clearance and Excretion of Intratracheally and Orally Administered Aflatoxin B1 in the Rat (with R. P. Sharma), Food and Chemical Toxicology (1985)

The pharmacokinetic disposition of intratracheally (i/t) and orally administered [3H]AFBt was studied in male Sprague-Dawley...

 

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The Effects of Route of Exposure and Combined Exposure of Mixed-Function Oxidase Inducers and Supressors on Hepatic Parameters in Rainbow Trout (Salmo gairdneri) (with T. A. Eisele, N. E. Pawlowski, and J. E. Nixon), Aquatic Toxicology (1984)

Hepatic microsomes obtained from rainbow trout (Salmo gairdneri) administered β-naphthoflavone (βNF) either by a single...

 

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Identification and Mutagenicity of Aflatoxicol M1 Produced by Metabolism of Aflatoxin B1 and Aflatoxicol by Liver Fractions from Rainbow Trout (Salmo Gairdneri) (with P. M. Loveland, L. M. Libbey, N. E. Pawlowski, R. O. Sinnhuber, and J. E. Nixon), Food and Chemical Toxicology (1983)

β-Naphthoflavone (βNF) fed to rainbow trout (Salmo gairdneri) at 50 or 500 ppm in the...

 

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Inhibitory Effect of Aroclor 1254 on Aflatoxin-Initiated Carcinogenesis in Rainbow Trout and Mutagenesis Using a Salmonella/Trout Hepatic Activation System (with Dennis W. Shelton, J. E. Hendricks, Cliff B. Pereira, and John L. Casteel), Aquatic Toxicology (1983)

Duplicate lots of 140 rainbow trout (Salmo gairdneri) were fed either control diet (CD) or...

 

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Time and Dose-Dependent Effects of Dietary Cyclopropenoid Fatty Acids on the Mixed-Function Oxidase System of Rainbow Trout (with T. A. Eisele, J. L. Williams, D. W. Shelton, and J. E. Nixon), Aquatic Toxicology (1983)

Rainbow trout (Salmo gairdneri) were fed diets containing various levels of cyclopropenoid fatty acids (CPFA's)...

 

Contributions to Books

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Pyrrolizidine Alkaloids in Foods, Advances in Food and Nutrition Research (2003)

In addition to the many well-known major nutrients (protein, fat, carbohydrate and fiber) and minor...

 

Conference Papers

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Genes Associated with Aflatoxin B1 Sensitivity (with S. Rawal and K. M. Reed), International Congress of Toxicology (2007)
 

Other

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Antioxidants Protect Turkeys Against Toxicity of Aflatoxin, NRI Research Highlights (2001)

Toxins stemming from mold in feed grains are unavoidable in poultry production. "Mycotoxins" such as...

 

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Does Nature Know Best? Natural Carcinogens and Anticarcinogens in American Food, ADVS Faculty Publications (1996)