This paper explores the development and application of a self-administered organizational diagnostic to assess the firm’s underlying business orientation. The research further explores the relationships between Entrepreneurial Orientation (EO), Market Orientation (MO), and Performance with high tech firms headquartered in the Silicon Valley. In this initial study of 89 respondents, we explored differences in business orientation between startups and established firms. We also examined whether the constructs and their measurements could be used to provide managerials recommendations for performance improvements. We found that the interaction between EO and MO was positively and significantly related to business performance.