The Pan-European Region made significant progress from 1995 to 2007 in improving the economic, social, environmental and health indicators incorporated into the Millennium Development Goals (MDGs). However, given the huge set-backs associated with the transition recession in the early 1990s and the more recent economic declines from the global financial crisis, achievement of some of the MDGs in a significant number of countries by 2015 is now problematic. The degree to which the actual targets can be achieved by 2015 will depend critically on: (i) the speed of recovery from the current crisis and the policy responses to it; (ii) the commitment by national governments to focus resources on the MDG objectives and their willingness to implement new policy initiatives, and (iii) the level of foreign assistance and regional cooperation that can be obtained. The EU new Member States (NMS) are most likely to meet the MDGs, while the prospects for the other European emerging economies are more mixed, especially for MDGs related to poverty and health. All of the Pan-European economies are falling short in terms of achieving environmental sustainability and gender equality.