While the literature on science, technology, engineering, and mathematics (STEM) is abound with the importance of increasing college access, retention, and persistence among students because of its implications for America’s global competitiveness, particular emphasis has been placed on students of color. Notwithstanding, students of color remain underrepresented in STEM education. Therefore, increasing access, retention, and persistence for students of color in STEM is not merely a matter of United States’ economic competitiveness, but also a matter of equity. Using in-depth interview methods, this article delineates factors facilitating the retention and persistence of students of color in STEM education at a predominantly White institution. Implications for institutional practice and future research are provided.