SelectedWorks - Robert J. Barsotti

Contact

Selected Works of Robert J. Barsotti

Professor

Dr. Robert Barsotti is a Professor in the department of Neuroscience, Physiology, and Pharmacology.

Works
About

About Robert J. Barsotti

Dr. Robert Barsotti is a Professor in the department of Neuroscience, Physiology, and Pharmacology.

Present	Professor, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Life Sciences

Neuromuscular Function and Disease and Cardiovascular Function and Disease

Department of Bio-Medical Sciences

Scholarly Articles (32)

Article

Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ...

PNAS Nexus (2023)

Haikel Dridi, Marc Yehya, Robert J. Barsotti, Yang Liu, et al.

In critical care patients, the “”temporary inactivity of the diaphragm caused by mechanical ventilation (MV) triggers a series of events ...

Download

Article

Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate ...

BMC Pharmacology & Toxicology (2021)

Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, et al.

BACKGROUND: Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or ...

Download

Article

Collagen Fibrils and Proteoglycans of Peripheral and Central Stroma of ...

Scientific Reports (2019)

Aljoharah Alkanaan, Robert J. Barsotti, Omar Kirat, Adnan Khan, et al.

Keratoconus (KC) is a progressive corneal disorder in which vision gradually deteriorates as a result of continuous conical protrusion and ...

Download

Article

Mitochondrial Oxidative Stress Induces Leaky Ryanodine Receptor During Mechanical Ventilation

Free Radical Biology and Medicine (2019)

Haikel Dridi, Mohamad Yehya, Robert J. Barsotti, Steven Reiken, et al.

RATIONALE: Ventilator-induced diaphragm dysfunction (VIDD) increases morbidity and mortality in critical care patients. Although VIDD has been associated with mitochondrial ...

OpenURL

Article

Comparing the Effects of Myristic Acid- and TAT-conjugated Peptides to ...

Current Topics in Peptide and Protein Research (2016)

Lindon H. Young, Robert J. Barsotti, Israel Benjamin, H. Patel, et al.

Two commonly used modifications of native peptides to increase peptide permeability through the cell membrane to target intracellular substrates are ...

Article

Determination of Regional Flow Utilizing Microspheres in ex vivo Myocardial ...

The FASEB Journal (2016)

Tarah Kuhn, Sabrina Clark, Daniel Kuo, Stephanie Liu, et al.

MI/R results in marked cardiac contractile dysfunction and cell death. We previously discovered that protein kinase C epsilon peptide inhibitor ...

Article

Effects of NOX-1 on Real-Time Blood Nitric Oxide and Hydrogen ...

The FASEB Journal (2016)

Ashley Mawhinney, Michael Bertolet, Michael Minni, Robert Barsotti, et al.

Hyperglycemia has been associated with vascular endothelial dysfunction in part by a reduction in nitric oxide (NO) production and increased ...

Article

The Role of NADPH Oxidase Isoform 1 (NOX1) in L-NAME-Induced ...

The FASEB Journal (2016)

Alita Zabrecky, Hung Pham, Amber Koon, Brian Reuter, et al.

Vascular endothelial dysfunction and subsequent inflammation underlie many pathological diseases such as cardiovascular disease, diabetes, and hypertension. Both events are ...

Article

Comparing the effectiveness of TAT and Myristoylation of gp91ds on ...

Proceedings of the 24th American Peptide Symposium (2015)

Harsh Patel, Kyle Bartol, Amelie Bottex, Ryan Remarcke, et al.

[No abstract is available]

Article

Mdivi-1, a Novel Mitochondrial Fission Inhibitor, Exerts Cardioprotective Effects in ...

The FASEB Journal (2015)

Devon Stutzman, Carly Schmidgall, Israel Benjamin, Qian Chen, et al.

MI/R results in cardiac contractile dysfunction and increased cell death. MI/R is initiated in part by uncoupling of the electron ...

Article

Protein Kinase C Beta II (PKC ßII) Peptide Inhibitor Exerts ...

Proceedings of the 24th American Peptide Symposium (2015)

Christina Lipscombe, Israel Benjamin, Devon Stutzman, Amelie Bottex, et al.

Coronary heart disease is the leading cause of death worldwide, and is primarily attributable to the detrimental effects of tissue ...

Article

Unaffected Contractility of Diaphragm Muscle Fibers in Humans on Mechanical ...

American journal of physiology. Lung cellular and molecular physiology (2014)

Pleuni E Hooijman, Marinus A Paul, Ger J M Stienen, Albertus Beishuizen, et al.

Several studies have indicated that diaphragm dysfunction develops in patients on mechanical ventilation (MV). Here, we tested the hypothesis that ...

OpenURL

Article

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ...

American journal of physiology.Lung cellular and molecular physiology (2014)

P. E. Hooijman, M. A. Paul, G. J. Stienen, A. Beishuizen, et al.

Several studies have indicated that diaphragm dysfunction develops in patients on mechanical ventilation (MV). Here, we tested the hypothesis that ...

Article

Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human ...

American Journal of Respiratory and Critical Care Medicine (2011)

Sanford Levine, Chhanda Biswas, Jamil Dierov, Robert J. Barsotti, et al.

RATIONALE: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating ...

Link

Article

Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human ...

American Journal of Respiratory and Critical Care Medicine (2011)

S. Levine, C. Biswas, J. Dierov, Robert J. Barsotti, et al.

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating ...

Article

Kinetics of Cardiac Thin-Filament Activation Probed by Fluorescence Polarization of ...

Biophysical Journal (2006)

Marcus G. Bell, Edward B. Lankford, Gregory E. Gonye, Graham C. R. Ellis-Davies, et al.

A genetically engineered cardiac TnC mutant labeled at Cys-84 with tetramethylrhodamine-5-iodoacetamide dihydroiodide was passively exchanged for the endogenous form in ...

Link

Article

Kinetics of cardiac thin-filament activation probed by fluorescence polarization of ...

Biophysical journal (2006)

Marcus G. Bell, E. B. Lankford, G. E. Gonye, G. C. R. Ellis-Davies, et al.

A genetically engineered cardiac TnC mutant labeled at Cys-84 with tetramethylrhodamine-5-iodoacetamide dihydroiodide was passively exchanged for the endogenous form in ...

Article

The nitrodibenzofuran chromophore: A new caging group for ultra-efficient photolysis ...

Nature Methods (2006)

A. Momotake, N. Lindegger, E. Niggli, Robert J. Barsotti, et al.

Photochemical uncaging of bio-active molecules was introduced in 1977, but since then, there has been no substantial improvement in the ...

Article

Tuning caged calcium: Photolabile analogues of EGTA with improved optical ...

Cell calcium (2006)

G. C. R. Ellis-Davies and Robert J. Barsotti

The physico-chemical properties of several Ca2+-selective, photolabile chelators are described. These molecules have been developed as part of an effort ...

Article

Activation Kinetics of Skinned Cardiac Muscle by Laser Photolysis of ...

Biophysical journal (2004)

H. Martin, Marcus G. Bell, G. C. R. Ellis-Davies and Robert J. Barsotti

The kinetics of Ca2+-induced contractions of chemically skinned guinea pig trabeculae was studied using laser photolysis of NP-EGTA. The amount ...

Article

Activation Kinetics of Skinned Cardiac Muscle by Laser Photolysis of ...

Biophysical journal (2004)

Hunter Martin, Marcus G. Bell, Graham C. Ellis-Davis and Robert J. Barsotti

The kinetics of Ca2+-induced contractions of chemically skinned guinea pig trabeculae was studied using laser photolysis of NP-EGTA. The amount ...

Download

Article

Cross-bridge versus thin filament contributions to the level and rate ...

Biophysical journal (2004)

M. Regnier, H. Martin, Robert J. Barsotti, A. J. Rivera, et al.

In striated muscle thin filament activation is initiated by Ca2+ binding to troponin C and augmented by strong myosin binding ...

Article

Stretch-induced calcium release in smooth muscle.

Department of Pathology, Anatomy, and Cell Biology Faculty Papers (2002)

Guangju Ji, Robert J Barsotti, Morris E Feldman and Michael I Kotlikoff

Smooth muscle cells undergo substantial increases in length, passively stretching during increases in intraluminal pressure in vessels and hollow organs. ...

Download

Article

Stretch-induced calcium release in smooth muscle

Journal of General Physiology (2002)

G. Ji, Robert J. Barsotti, M. E. Feldman and M. I. Kotlikoff

Smooth muscle cells undergo substantial increases in length, passively stretching during increases in intraluminal pressure in vessels and hollow organs. ...

Article

Loading of calcium and strontium into the sarcoplasmic reticulum in ...

Journal of Molecular and Cellular Cardiology (2000)

C. I. Spencer, Robert J. Barsotti and J. R. Berlin

Previous work suggests that strontium ions (Sr2+) are less effective than calcium ions (Ca2+) at supporting excitation-contraction (EC) coupling in ...

About Robert J. Barsotti

Positions

Disciplines

Research Interests

Links

Scholarly Articles (32)