Helping college students thrive is perhaps of greatest concern with those students who are most at risk to depart before obtaining a degree. Current efforts in higher education to promote academic persistence and success among high-risk students are not generally effective, especially among four-year institutions. In addition to a discussion of remedial education and high-risk students, this chapter advocates for the need to help these students thrive. Two recent studies highlight the importance of thriving for high-risk students. The first study utilizes a qualitative research methodology in order to understand the experiences of academically successful graduating seniors who were labeled high-risk when admitted to the institution as first-year students. The second study utilizes an experimental design with quantitative analyses to demonstrate how a thriving intervention can positively impact the success of high-risk students. The results of both studies, when combined with the existing literature on college student success, have numerous implications for higher education scholars and practitioners.