The large deviation principle is proved for a class of L2-valued processes that arise from the coarse-graining of a random field. Coarse-grained processes of this kind form the basis of the analysis of local mean-field models in statistical mechanics by exploiting the long-range nature of the interaction function defining such models. In particular, the large deviation principle is used in a companion paper [8] to derive the variational principles that characterize equilibrium macrostates in statistical models of two-dimensional and quasi-geostrophic turbulence. Such macrostates correspond to large-scale, long-lived flow structures, the description of which is the goal of the statistical equilibrium theory of turbulence. The large deviation bounds for the coarse-grained process under consideration are shown to hold with respect to the strong L2 topology, while the associated rate function is proved to have compact level sets with respect to the weak topology. This compactness property is nevertheless sufficient to establish the existence of equilibrium macrostates for both the microcanonical and canonical ensembles.