Article
A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
Organic Letters
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
1-1-2009
DOI
10.1021/ol902051v
Abstract
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
Copyright Owner
American Chemical Society
Copyright Date
2009
Language
en
File Format
application/pdf
Citation Information
Wei Gao, Matthew L. Hillwig, Luqi Huang, Guanghong Cui, et al.. "A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights" Organic Letters Vol. 11 Iss. 22 (2009) p. 5170 - 5173 Available at: http://works.bepress.com/reuben_peters/66/
This article is published as A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights, Wei Gao, Matthew L. Hillwig, Luqi Huang, Guanghong Cui, Xueyong Wang, Jianqiang Kong, Bin Yang, and Reuben J. Peters, Organic Letters 2009 11 (22), 5170-5173, DOI: 10.1021/ol902051v. This article is made available via ACS AuthorChoice.