I study molecular pathways involved in environmental chemical stress. Many toxic effects depend on binding and activation of intracellular receptor proteins, which also act as transcription factors. By focusing on structural and functional diversity of these receptors and their regulation among wide ranging vertebrate taxa, I aim to reveal mechanisms of toxicity and relationships between target genes and species sensitivity to chemical exposure.
Interaction of Fish Aryl Hydrocarbon Receptor Paralogs (AHR1 and AHR2) with the Retinoblastoma Protein (with Sibel I. Karchner and Mark E. Hahn), Faculty Publications (2009)
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) and related compounds....