Rebecca Prosser

University of Tennessee, Knoxville

Honors & Awards

2010 NIH RO1 “Effects of Ethanol on the Mammalian Circadian Clock (Co-PI, J.D. Glass, Kent State Univ. (4 year, $1,134,566 direct costs)
2009 SUBMITTED NIH grant “Extracellular modulation of glutamate signaling” (Co- PI’s: C.B. Peterson, UTK and E. Mintz, Kent State Univ.)
2009 Haines-Morris Endowment ($3220)
2007 NIH R21 grant “Ethanol Effects in the Mammalian Circadian Clock” (Co-PI, J.D.Glass, Kent State Univ.)(2 year, $275,000)
2005 UT Small Grant Award ($20,000)
2005 UT Professional Development Award ($5000): “Pharmacology of serotonergic clock resetting action of 5HT on the mouse circadian clock located in the suprachiasmatic nucleus (SCN)”
2003 UT Professional Development Award ($4750): Serotonin Receptor Immunohistochemistry in the Suprachiasmatic Nucleus
2002 UT SARIF Small Grant Award ($20,000)
2002 UT Professional Development Award “In vitro rhythms in mice” ($3500)
1997 NSF ILI-IP award: "Undergraduate Neurobiology Laboratory" (($61,610) (Co-PI with Jim Hall)
1995 NIH FIRST award "In vitro interactions between circadian clock afferents" ($484,764)

TTX Blocks Baclofen-induced Phase Shifts of the Mammalian Circadian Pacemaker in Vitro

Rebecca Prosser, University of Tennessee - Knoxville
Harriet E. Bergeron, University of Tennessee - Knoxville
Blaine Danielson, University of Tennessee - Knoxville
Kevin R. Biggs, University of Tennessee - Knoxville

Abstract

The mammalian circadian pacemaker, located in the suprachiasmatic nucleus (SCN), expresses 24-h rhythms when isolated in vitro. The GABA_A agonist, muscimol, induces phase advances during the mid-subjective day, while the GABA_B agonist, baclofen, induces both daytime phase advances and nighttime phase delays. Here, we present evidence that tetrodotoxin (TTX) completely blocks baclofen-induced phase shifts in vitro, but does not block in vitro phase advances induced by muscimol. These results suggest that GABA_A, but not GABA_B, receptors are located on SCN pacemaker cells.

Suggested Citation

Rebecca Prosser, Harriet E. Bergeron, Blaine Danielson, and Kevin R. Biggs. "TTX Blocks Baclofen-induced Phase Shifts of the Mammalian Circadian Pacemaker in Vitro" Brain Research 841.1-2 (1999): 193-196.

Link to Full Text

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SelectedWorks of Rebecca Prosser