GABAB Receptor Stimulation Phase-shifts the Mammalian Circadian Clock In Vitro
The mammalian circadian clock in the suprachiasmatic nucleus (SCN) generates 24-h rhythms in vitro. Here we show that the GABAB agonist baclofen resets the SCN pacemaker in vitro in a phase-dependent manner: advances were induced at zeitgeber time (ZT) 6, and delays were induced at ZT 22. Both effects were blocked the GABAB antagonist, 2-hydroxysaclofen, while the GABAA antagonist, bicuculline was ineffective. Thus, the SCN pacemaker is sensitive to resetting by GABAB stimulation.
Rebecca Prosser and Kevin R. Biggs. "GABAB Receptor Stimulation Phase-shifts the Mammalian Circadian Clock In Vitro" Brain Research 807.1-2 (1998): 250-254.