Rebecca Prosser

University of Tennessee, Knoxville

Honors & Awards

2010 NIH RO1 “Effects of Ethanol on the Mammalian Circadian Clock (Co-PI, J.D. Glass, Kent State Univ. (4 year, $1,134,566 direct costs)
2009 SUBMITTED NIH grant “Extracellular modulation of glutamate signaling” (Co- PI’s: C.B. Peterson, UTK and E. Mintz, Kent State Univ.)
2009 Haines-Morris Endowment ($3220)
2007 NIH R21 grant “Ethanol Effects in the Mammalian Circadian Clock” (Co-PI, J.D.Glass, Kent State Univ.)(2 year, $275,000)
2005 UT Small Grant Award ($20,000)
2005 UT Professional Development Award ($5000): “Pharmacology of serotonergic clock resetting action of 5HT on the mouse circadian clock located in the suprachiasmatic nucleus (SCN)”
2003 UT Professional Development Award ($4750): Serotonin Receptor Immunohistochemistry in the Suprachiasmatic Nucleus
2002 UT SARIF Small Grant Award ($20,000)
2002 UT Professional Development Award “In vitro rhythms in mice” ($3500)
1997 NSF ILI-IP award: "Undergraduate Neurobiology Laboratory" (($61,610) (Co-PI with Jim Hall)
1995 NIH FIRST award "In vitro interactions between circadian clock afferents" ($484,764)

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GABA_B Receptor Stimulation Phase-shifts the Mammalian Circadian Clock In Vitro

Rebecca Prosser, University of Tennessee - Knoxville
Kevin R. Biggs, University of Tennessee - Knoxville

Abstract

The mammalian circadian clock in the suprachiasmatic nucleus (SCN) generates 24-h rhythms in vitro. Here we show that the GABA_B agonist baclofen resets the SCN pacemaker in vitro in a phase-dependent manner: advances were induced at zeitgeber time (ZT) 6, and delays were induced at ZT 22. Both effects were blocked the GABA_B antagonist, 2-hydroxysaclofen, while the GABA_A antagonist, bicuculline was ineffective. Thus, the SCN pacemaker is sensitive to resetting by GABA_B stimulation.

Suggested Citation

Rebecca Prosser and Kevin R. Biggs. "GABA_B Receptor Stimulation Phase-shifts the Mammalian Circadian Clock In Vitro" Brain Research 807.1-2 (1998): 250-254.

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Rebecca Prosser

University of Tennessee, Knoxville

Honors & Awards

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GABAB Receptor Stimulation Phase-shifts the Mammalian Circadian Clock In Vitro

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GABA_B Receptor Stimulation Phase-shifts the Mammalian Circadian Clock In Vitro