Short-term hemodynamic evaluation of circumferential mitral annuloplasty for correction of mitral valve regurgitation in dogs
OBJECTIVE: To determine the short-term hemodynamic effects associated with circumferential mitral annuloplasty (CMA) in dogs with mitral regurgitation. STUDY DESIGN: Prospective experimental study. Animals-Seven healthy adult mongrel dogs. METHODS: Mitral regurgitation was surgically induced, and annular dilation occurred. Echocardiography and cardiac catheterization were used to determine forward ejection fraction (FEF), regurgitant fraction (RF), pulmonary capillary wedge pressure (PCWP), and annular diameter before and immediately after CMA in five dogs. FEF and RF were also evaluated 7 days after annuloplasty. RESULTS: Mean annular diameter and PCWP were significantly reduced immediately after CMA. Significant increases in FEF of 19% and 22% were shown immediately and 7 days after CMA. Significant reductions in RF of 19% and 22% were also shown immediately and 7 days after annuloplasty. CONCLUSIONS: Sustained hemodynamic benefits and a reduction in annular diameter were achieved by CMA in a canine model of mitral regurgitation. CLINICAL IMPLICATIONS: CMA may be a suitable treatment for heart failure because of mitral regurgitation when early signs of cardiovascular decompensation persist despite appropriate medical management.
K Kerstetter, J Sackman, J Buchanan, J M. Bright, D J. Krahwinkel, R Bright, D Lorinson, and Rebecca Elaine Gompf. "Short-term hemodynamic evaluation of circumferential mitral annuloplasty for correction of mitral valve regurgitation in dogs" Veterinary Surgery 27.3 (1998): 216-223.
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