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An Efficient Method for the Chemoselective Synthesis of Acylals from Aromatic Aldehydes Using Bismuth Triflate

Ram S. Mohan, Illinois Wesleyan University
Marc D. Carrigan
Kyle J. Eash
Matthew C. Oswald

Abstract

Aromatic aldehydes are smoothly converted into the corresponding acylals in good yields in the presence of 0.10 mol% Bi(OTf)3•xH2O. Ketones are not affected under the reaction conditions. The highly catalytic nature of bismuth triflate and the fact that it is relatively non-toxic, easy to handle and insensitive to small amounts of air and moisture makes this procedure especially attractive for large-scale synthesis.

Suggested Citation

Ram S. Mohan, Marc D. Carrigan, Kyle J. Eash, and Matthew C. Oswald. "An Efficient Method for the Chemoselective Synthesis of Acylals from Aromatic Aldehydes Using Bismuth Triflate" Tetrahedron 42 (2001): 8133-8135.
Available at: http://works.bepress.com/ram_mohan/14