Journal articles
Antimalarial Activity of 2,4-Diaminopyrimidines (with J. Morgan and R. Haritakul), Faculty of Science - Papers (2008)
A series of 2,4- and 4,6-diaminopyrimidines were prepared and evaluated for their in vitro antimalarial...
New Cyclic Peptides via Ring-Closing Metathesis Reactions and Their Anti-Bacterial Activities (with T. P. Boyle, J. B. Bremner, J. Coates, J. Deadman, Stephen G. Pyne, and D. I. Rhodes), Faculty of Science - Papers (2008)
As part of a program investigating cyclic peptides with an internal aromatic hydrophobic scaffold as...
Oxidative coupling of indoles using thallium(III) trifluoroacetate (with N. R. Yepuri, M. J. Kelso, M. Mariani, B. W. Skelton, and A. H. White), Faculty of Science - Papers (2008)
The oxidative coupling of polysubstituted electron-rich indoles mediated by thallium trifluoroacetate was found to be...
Control of HIV Through the Inhibition of HIV-1 Integrase: A Medicinal Chemistry Perspective (with C. P. Gordon and R. Griffith), Faculty of Science - Papers (2007)
This article reviews the current status of classes of HIV-1 integrase enzyme inhibitors. These classes...
A New Methodology for the Simulation of Flexible Protein – Ligand Interactions (with J. Garner, J. Deadman, D. Rhodes, and R. Griffith), Faculty of Science - Papers (2007)
A methodology has been developed for the simulation of induced fit between a ligand and...
Aryl Nitro Reduction with Iron Powder or Stannous Chloride under Ultrasonic Irradiation (with A. B. Gamble, J. Garner, C. P. Gordon, and S. M. J. O'Conner), Faculty of Science - Papers (2007)
The selective reduction of aryl nitro compounds in the presence of sensitive functionalities, including halide,...
Corticotropin Releasing Hormone - a GPCR Drug Target (with C. Hemley and A. McCluskey), Faculty of Science - Papers (2007)
Corticotrophin Releasing Hormone (CRH) is a primary hormone in the fight or flight response targeting...
Synthesis of some cyclic indolic peptoids as potential antibacterials (with V. S. Au, J. B. Bremner, J. Coates, and Stephen G. Pyne), Faculty of Science - Papers (2006)
The synthesis of cyclic peptoids containing an indole hydrophobic scaffold has been realised through the...
The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents (with N. R. Yepuri, R. Haritakul, R. Griffith, and S. P. Leach), Faculty of Science - Papers (2006)
The anti-malarial activity of the arenearylpyrimidylmethane (AAPM) class of compounds emerged from database searching of...
Reactions of Iminoglycines with C60 Fullerene and their Unambiguous Characterisation using NMR Spectroscopy (with Stephen G. Pyne and B. C. Hawkins), Faculty of Science - Papers (2006)
This review examines the addition of iminoglycine derivatives to C60, yielding protected fullerenyl pyrroline derivatives....
The Role of the HPA Axis in Psychiatric Disorders and CRF Antagonists as Potential Treatments (with A. McCluskey, J. Morgan, and S. M. O'Connor), Faculty of Science - Papers (2006)
An overview of the links between the Hypothalamic-Pituitary-Adrenal (HPA) axis and psychiatric disorders is presented....
Synthesis and In Vitro Binding of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides for the Peripheral Benzodiazepine Binding Sites (with T. P. Homes, F. Mattner, and A. Katsifis), Faculty of Science - Papers (2006)
A series of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides bearing the halogens iodine and bromine were synthesised and their binding...
Regioselective synthesis of novel e-edge-[60]fullerenylmethanodihydropyrroles and 1,2-dihydromethano[60]fullerenes (with L. Chaker, G. E. Ball, J. R. Williams, G. A. Burley, B. C. Hawkins, and Stephen G. Pyne), Faculty of Science - Papers (2005)
Treatment of a tethered N-(diphenylmethylene)glycinate-malonate derivative with [60]fullerene under Bingel conditions yielded an e-edge-[60]fullerenylmethanodihydropyrrole adduct...
A Convenient and Efficient Synthesis of (S)-Lysine and (S)-Arginine Homologues via Olefin Cross Metathesis (with T. P. Boyle, J. B. Bremner, J. A. Coates, and Stephen G. Pyne), Faculty of Science - Papers (2005)
A convenient five step synthesis of (S)-homolysine, incorporating a key olefin cross-metathesis step in the...
Combining Structure-Based Drug Design and Pharmacophores (with R. Griffith, T. T. T. Luu, and J. Garner), Faculty of Science - Papers (2005)
Development towards integrated computer-aided drug design methodologies is presented by utilising crystal structure complexes to...
Novel Pharmacophore Based Methods Reveal Gossypol as a Reverse Transcriptase Inhibitor (with C. Birch, S. P. Leach, D. Tyssen, and R. Griffith), Faculty of Science - Papers (2003)
In a program to identify new structural entities for the inhibition of the HIV-1 reverse...
The prevention of preterm labour – Corticotropin Releasing Hormone type 1 receptors as a target for drug design and development (with K. Kirkwood, J. Morgan, S. Westcott, and A. McCluskey), Faculty of Science - Papers (2003)
The role of the corticotropin releasing hormone in the onset of labour and the subsequent...
[60]Fullerene Amino Acids and Related Derivatives (with G. A. Burley and Stephen G. Pyne), Faculty of Science - Papers (1999)
This paper is a review of the literature concerning the preparation of [60]fullerene amino acid...
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Atroposelective synthesis of axially chiral biaryl compounds (with G. Bringmann, A. J. Mortimer, M. J. Gresser, J. Garner, and M. Breuning), Angewandte Chemie - International Edition (2005)
A rotationally hindered and thus stereogenic biaryl axis is the structurally and stereochemically decisive element...