Synthesis of some cyclic indolic peptoids as potential antibacterials

V. S. Au, University of Wollongong
J. B. Bremner, University of Wollongong
J. Coates, Avexa Ltd, Richmond, Victoria
P. A. Keller, University of Wollongong
Stephen G. Pyne, University of Wollongong

Article comments

This article was originally published as: Au, VS, Bremner, JB, Coates, J, et al, Synthesis of some cyclic indolic peptoids as potential antibacterials, Tetrahedron, 2006, 62(40), 9373-9382. The original journal can be found here through Elsevier.

Abstract

The synthesis of cyclic peptoids containing an indole hydrophobic scaffold has been realised through the ring-closing metathesis of diallylated precursors. The precursors and their cyclic counterparts possessed poor antibacterial activity in contrast to previously reported cyclic peptoids containing hydrophobic scaffolds.