Research Interests: Bioorganic and Medicinal Chemistry. The design and synthesis of new agents for therapeutic use. Techniques include: * organic synthesis, including methodology development, with an emphasis on the asymmetric synthesis of sterically hindered systems, spiro compounds, and new fullerenyl derivatives; * Computer-aided molecular modeling, with the design of new targets and methodology development investigating flexible protein systems.
Articles
Antimalarial Activity of 2,4-Diaminopyrimidines (with J. Morgan and R. Haritakul), Faculty of Science - Papers (2008)
A series of 2,4- and 4,6-diaminopyrimidines were prepared and evaluated for their in vitro antimalarial...
New Cyclic Peptides via Ring-Closing Metathesis Reactions and Their Anti-Bacterial Activities (with T. P. Boyle, J. B. Bremner, J. Coates, J. Deadman, Stephen G. Pyne, and D. I. Rhodes), Faculty of Science - Papers (2008)
As part of a program investigating cyclic peptides with an internal aromatic hydrophobic scaffold as...
Oxidative coupling of indoles using thallium(III) trifluoroacetate (with N. R. Yepuri, M. J. Kelso, M. Mariani, B. W. Skelton, and A. H. White), Faculty of Science - Papers (2008)
The oxidative coupling of polysubstituted electron-rich indoles mediated by thallium trifluoroacetate was found to be...
Control of HIV Through the Inhibition of HIV-1 Integrase: A Medicinal Chemistry Perspective (with C. P. Gordon and R. Griffith), Faculty of Science - Papers (2007)
This article reviews the current status of classes of HIV-1 integrase enzyme inhibitors. These classes...
A New Methodology for the Simulation of Flexible Protein – Ligand Interactions (with J. Garner, J. Deadman, D. Rhodes, and R. Griffith), Faculty of Science - Papers (2007)
A methodology has been developed for the simulation of induced fit between a ligand and...