gpDB: a database of G-proteins, GPCRs, Effectors and their interactions

Margarita C. Theodoropoulou, University of Athens
Pantelis G. Bagos, University of Central Greece
Ioannis C. Spyropoulos, University of Athens
Stavros J. Hamodrakas, University of Athens

Abstract

SUMMARY: gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database.

AVAILABILITY: http://bioinformatics.biol.uoa.gr/gpDB

CONTACT: shamodr@biol.uoa.gr

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.