Monocytes
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Macrophage Colony-Stimulating Factor
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1 (with Sandy C. Marks Jr., Carin Lundmark, Tilmann Wurtz, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), Developmental dynamics : an official publication of the American Association of Anatomists (1999)
The toothless (osteopetrotic) mutation in the rat is characterized by retarded development of the anterior...
Academic Dissertations
Molecular Characterization of Mitofilin, a Novel, Mitochondrial, Coiled Coil Protein, and the Relationship Between Organism Complexity and Coiled Coil Protein-Mediated Structure, GSBS Dissertations and Theses (1995)
In the course of experiments designed to identify and characterize structural proteins of the nuclear...
Transforming Growth Factor beta1
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Proto-Oncogene Proteins
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Cartilage
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Neovascularization, Physiologic
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Rats, Mutant Strains
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Tibia
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Osteopetrosis
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Cryopreservation
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Uterine Cervical Neoplasms
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Oxidation-Reduction
PAMM: a redox regulatory protein that modulates osteoclast differentiation (with Yan Xu, Leslie R. Morse, Raquel Assed Bezerra da Silva, Hajime Sasaki, Philip Stashenko, and Ricardo A. Battaglino), Antioxidants and redox signaling (2010)
The central role of reactive oxygen species (ROS) in osteoclast differentiation and in bone homeostasis...
Thymidine Kinase
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Flow Cytometry
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Antibody Specificity
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Gene Expression Regulation
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Up-Regulation
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Dissertations, UMMS
Molecular Characterization of Mitofilin, a Novel, Mitochondrial, Coiled Coil Protein, and the Relationship Between Organism Complexity and Coiled Coil Protein-Mediated Structure, GSBS Dissertations and Theses (1995)
In the course of experiments designed to identify and characterize structural proteins of the nuclear...
Recombinant Protein
Molecular Characterization of Mitofilin, a Novel, Mitochondrial, Coiled Coil Protein, and the Relationship Between Organism Complexity and Coiled Coil Protein-Mediated Structure, GSBS Dissertations and Theses (1995)
In the course of experiments designed to identify and characterize structural proteins of the nuclear...
Antibodies, Monoclonal
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Organ Specificity
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
RNA
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1 (with Sandy C. Marks Jr., Carin Lundmark, Tilmann Wurtz, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), Developmental dynamics : an official publication of the American Association of Anatomists (1999)
The toothless (osteopetrotic) mutation in the rat is characterized by retarded development of the anterior...
The nuclear matrix: defining structural and functional roles (with Edward G. Fey, Peter Lawrence Bangs, and Cynthia A. Sparks), Critical reviews in eukaryotic gene expression (1991)
Osteoclasts
Using osteoclast differentiation as a model for gene discovery in an undergraduate cell biology laboratory (with Mark J. Birnbaum, Jenna Picco, Meghan Clements, Hanna Witwicka, Meilheng Yang, and Margaret T. Hoey), Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology (2010)
A key goal of molecular/cell biology/biotechnology is to identify essential genes in virtually every physiological...
PAMM: a redox regulatory protein that modulates osteoclast differentiation (with Yan Xu, Leslie R. Morse, Raquel Assed Bezerra da Silva, Hajime Sasaki, Philip Stashenko, and Ricardo A. Battaglino), Antioxidants and redox signaling (2010)
The central role of reactive oxygen species (ROS) in osteoclast differentiation and in bone homeostasis...
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Erythroid-Specific DNA-Binding Factors
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Carrier Proteins
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Gene Deletion
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Hela Cells
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Vacuolar Proton-Translocating ATPases
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Transfection
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Mice, Inbred BALB C
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Bacterial Proteins
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Amino Acid Sequence
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Humans
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Mice, Inbred C57BL
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Immunohistochemistry
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Genetic Predisposition to Disease
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Recombinant Proteins
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Microscopy, Immunoelectron
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Cricetinae
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Pedigree
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Introns
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Mice
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
S Phase
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Retinoblastoma-Like Protein p107
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Membrane Proteins
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Rats
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Plant Proteins
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Transcription Factors
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Microscopy, Fluorescence
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Mitochondrial Proteins
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Mice, Knockout
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Cartilage, Articular
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Growth Plate
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Ovarian Neoplasms
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Glycoproteins
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Extracellular Matrix
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Bone Diseases, Developmental
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Mitochondria
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
RNA, Small Interfering
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Adaptor Proteins, Vesicular Transport
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Bone Development
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Enzyme Activation
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Nuclear Proteins
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
The nuclear matrix: defining structural and functional roles (with Edward G. Fey, Peter Lawrence Bangs, and Cynthia A. Sparks), Critical reviews in eukaryotic gene expression (1991)
Receptors, Tumor Necrosis Factor
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
DNA-Binding Proteins
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Hematopoietic Stem Cells
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Nuclear Pore Complex Proteins
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Species Specificity
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Extracellular Matrix Proteins
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Epithelium
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Epithelial Cells
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
rab GTP-Binding Proteins
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Rats, Inbred Lew
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Tumor Necrosis Factor-alpha
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Viral Proteins
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Glycosaminoglycans
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Nuclear Matrix
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Molecular Characterization of Mitofilin, a Novel, Mitochondrial, Coiled Coil Protein, and the Relationship Between Organism Complexity and Coiled Coil Protein-Mediated Structure, GSBS Dissertations and Theses (1995)
In the course of experiments designed to identify and characterize structural proteins of the nuclear...
The nuclear matrix: defining structural and functional roles (with Edward G. Fey, Peter Lawrence Bangs, and Cynthia A. Sparks), Critical reviews in eukaryotic gene expression (1991)
Blotting, Western
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Cell Nucleus
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Cells, Cultured
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Histocytochemistry
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Receptors, Chemokine
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
RANK Ligand
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Ribs
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Isoenzymes
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Male
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Coloring Agents
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Detergents
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Lymph Nodes
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Gene Expression Regulation, Developmental
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Acid Phosphatase
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Sp3 Transcription Factor
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Cell Compartmentation
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Oxidative Stress
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Tumor Cells, Cultured
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Sequence Analysis
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Proton-Translocating ATPases
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Bone Morphogenetic Protein 5
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Phosphoproteins
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Computational Biology
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Binding Sites
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Oligonucleotide Array Sequence Analysis
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Animals, Newborn
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Oligodeoxyribonucleotides
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Fluorescent Antibody Technique
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
purification
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Retinoblastoma-Like Protein p130
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Recombinant Fusion Proteins
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
beta-Galactosidase
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Immediate-Early Proteins
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Chromosome Mapping
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Maxillofacial Development
Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1 (with Sandy C. Marks Jr., Carin Lundmark, Tilmann Wurtz, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), Developmental dynamics : an official publication of the American Association of Anatomists (1999)
The toothless (osteopetrotic) mutation in the rat is characterized by retarded development of the anterior...
Osteogenesis
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Cathepsins
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Protein Binding
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Bone Marrow Cells
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
RNA, Messenger
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Actins
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Cyclins
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Osteoblasts
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Microtubules
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
G1 Phase
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
*Angioplasty, Balloon
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Gene Expression
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Calcification, Physiologic
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Gene Expression Profiling
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Receptors, CCR1
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Mitochondrial Swelling
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Collagen
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1 (with Sandy C. Marks Jr., Carin Lundmark, Tilmann Wurtz, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), Developmental dynamics : an official publication of the American Association of Anatomists (1999)
The toothless (osteopetrotic) mutation in the rat is characterized by retarded development of the anterior...
Database Management Systems
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Female
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Cell Transformation, Neoplastic
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Mutation
Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies (with Craig H. Pratt, Carole A. MacKay, April Mason-Savas, Michelle Curtain, Lindsay S. Shopland, Tsutomu Ichicki, John P. Sundberg, and Leah Rae Donahue), PloS one (2010)
BACKGROUND: Investigations of naturally-occurring mutations in animal models provide important insights and valuable disease models....
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Rats, Inbred Strains
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Tolonium Chloride
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Molecular Sequence Data
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Tooth Eruption
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Adaptor Proteins, Signal Transducing
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Histological Techniques
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Down-Regulation
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Connective Tissue Growth Factor
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Sequence Homology, Amino Acid
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Base Sequence
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Chemokines, CC
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Tetrahydrofolate Dehydrogenase
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Cervix Uteri
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Homeodomain Proteins
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Polymerase Chain Reaction
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
False Positive Reactions
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Animals
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Histones
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Dental Sac
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Ion Pumps
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Bone Resorption
Using osteoclast differentiation as a model for gene discovery in an undergraduate cell biology laboratory (with Mark J. Birnbaum, Jenna Picco, Meghan Clements, Hanna Witwicka, Meilheng Yang, and Margaret T. Hoey), Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology (2010)
A key goal of molecular/cell biology/biotechnology is to identify essential genes in virtually every physiological...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Receptors, Cytoplasmic and Nuclear
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Retinoblastoma Protein
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Immunoenzyme Techniques
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Sp1 Transcription Factor
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Cell Differentiation
Using osteoclast differentiation as a model for gene discovery in an undergraduate cell biology laboratory (with Mark J. Birnbaum, Jenna Picco, Meghan Clements, Hanna Witwicka, Meilheng Yang, and Margaret T. Hoey), Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology (2010)
A key goal of molecular/cell biology/biotechnology is to identify essential genes in virtually every physiological...
PAMM: a redox regulatory protein that modulates osteoclast differentiation (with Yan Xu, Leslie R. Morse, Raquel Assed Bezerra da Silva, Hajime Sasaki, Philip Stashenko, and Ricardo A. Battaglino), Antioxidants and redox signaling (2010)
The central role of reactive oxygen species (ROS) in osteoclast differentiation and in bone homeostasis...
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Cloning, Molecular
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
DNA Primers
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Cell Cycle
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
TNF Receptor-Associated Factor 6
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Drosophila
Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 (with Mark J. Birnbaum, Andre J. Van Wijnen, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein), Biochemistry (1995)
The transcription factor Sp1 plays a key role in the activation of many cellular and...
Molecular Structure
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Bone and Bones
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice (with Carole A. MacKay, April Mason-Savas, Meilheng Yang, Genevieve Mailhot, and Mark J. Birnbaum), Connective tissue research (2006)
Escherichia coli beta-galactosidase (beta-gal), encoded by the lacZ gene, has become an essential tool in...
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Neoplasm Proteins
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Nuclear Envelope
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Antibodies
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Molecular Characterization of Mitofilin, a Novel, Mitochondrial, Coiled Coil Protein, and the Relationship Between Organism Complexity and Coiled Coil Protein-Mediated Structure, GSBS Dissertations and Theses (1995)
In the course of experiments designed to identify and characterize structural proteins of the nuclear...
Osteoprotegerin
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
DNA
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
The nuclear matrix: defining structural and functional roles (with Edward G. Fey, Peter Lawrence Bangs, and Cynthia A. Sparks), Critical reviews in eukaryotic gene expression (1991)
Receptor, Macrophage Colony-Stimulating Factor
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Hydrogen-Ion Concentration
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Reactive Oxygen Species
PAMM: a redox regulatory protein that modulates osteoclast differentiation (with Yan Xu, Leslie R. Morse, Raquel Assed Bezerra da Silva, Hajime Sasaki, Philip Stashenko, and Ricardo A. Battaglino), Antioxidants and redox signaling (2010)
The central role of reactive oxygen species (ROS) in osteoclast differentiation and in bone homeostasis...
Disease Models, Animal
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Intercellular Signaling Peptides and Proteins
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Cell Nucleolus
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Transcription, Genetic
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Cross Reactions
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Antiporters
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
YY1 Transcription Factor
The nuclear matrix protein NMP-1 is the transcription factor YY1 (with Bo Guo, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein), Proceedings of the National Academy of Sciences of the United States of America (1995)
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for...
Lymphotoxin-alpha
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Muscle Proteins
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Bone Morphogenetic Proteins
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
Phenotype
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Microarray Analysis
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
Reverse Transcriptase Polymerase Chain Reaction
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation (with Meilheng Yang, Mark J. Birnbaum, Carole A. MacKay, April Mason-Savas, and Benjamin Thompson), Journal of cellular physiology (2008)
Microarray and real-time RT-PCR were used to examine expression changes in primary bone marrow cells...
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
CSF-1 regulation of osteoclastogenesis for tooth eruption (with Gary E. Wise, S. Yao, and Feng Pan), Journal of dental research (2005)
The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat...
Membrane Glycoproteins
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Education
Using osteoclast differentiation as a model for gene discovery in an undergraduate cell biology laboratory (with Mark J. Birnbaum, Jenna Picco, Meghan Clements, Hanna Witwicka, Meilheng Yang, and Margaret T. Hoey), Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology (2010)
A key goal of molecular/cell biology/biotechnology is to identify essential genes in virtually every physiological...
Microscopy, Electron
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Lamins
Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies (with Craig H. Pratt, Carole A. MacKay, April Mason-Savas, Michelle Curtain, Lindsay S. Shopland, Tsutomu Ichicki, John P. Sundberg, and Leah Rae Donahue), PloS one (2010)
BACKGROUND: Investigations of naturally-occurring mutations in animal models provide important insights and valuable disease models....
Protein Conformation
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Phylogenetic occurrence of coiled coil proteins: implications for tissue structure in metazoa via a coiled coil tissue matrix (with Lawrence W. Harvie and Edward G. Fey), Proteins (1996)
We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic...
Chondrocytes
Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections (with Alison Gartland, April Mason-Savas, Meilheng Yang, Carole A. MacKay, and Mark J. Birnbaum), The American journal of pathology (2009)
The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on...
BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures (with Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole A. MacKay, and Irwin Leav), Journal of cellular physiology (2007)
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through...
In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: an improved isolation and cryopreservation method (with Alison Gartland, Joshua Mechler, April Mason-Savas, Carole A. MacKay, Genevieve Mailhot, and Sandy C. Marks Jr.), Bone (2005)
INTRODUCTION: Isolating and culturing primary chondrocytes such that they retain their cell type and differentiate...
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Caspases
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Receptors, G-Protein-Coupled
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Cytoskeletal Proteins
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Chloride Channels
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Sequence Homology, Nucleic Acid
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Receptor Activator of Nuclear Factor-kappa B
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Rats, Sprague-Dawley
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
DNA, Complementary
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex (with Peter Lawrence Bangs, Cynthia A. Sparks, and Edward G. Fey), Journal of cellular biochemistry (1996)
We have identified a component of the human nuclear pore complex and have shown that...
Macrophage Inflammatory Proteins
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Exons
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2 (with B. Perdu, Liesbeth van Wesenbeeck, K. Jennes, Carole A. MacKay, and W. Van Hul), Calcified tissue international (2009)
Osteopetrosis is a disease characterised by a generalized skeletal sclerosis resulting from a reduced osteoclast-mediated...
Cell Biology
Using osteoclast differentiation as a model for gene discovery in an undergraduate cell biology laboratory (with Mark J. Birnbaum, Jenna Picco, Meghan Clements, Hanna Witwicka, Meilheng Yang, and Margaret T. Hoey), Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology (2010)
A key goal of molecular/cell biology/biotechnology is to identify essential genes in virtually every physiological...
Kidney
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans (with Liesbeth van Wesenbeeck, Fraser P. Coxon, Annalisa Frattini, Pierre Moens, Bram Perdu, Carole A. MacKay, Els Van Hul, Jean-Pierre Timmermans, Filip Vanhoenacker, Ruben Jacobs, Barbara Peruzzi, Anna Teti, Miep H. Helfrich, Michael J. Rogers, Anna Villa, and Wim Van Hul), The Journal of clinical investigation (2007)
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations...
Hyperplasia
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Cell Line
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts (with Ricardo A. Battaglino, L. Pham, Leslie R. Morse, M. Vokes, A. Sharma, Meilheng Yang, Hajime Sasaki, and Philip Stashenko), Bone (2008)
Bone resorption is regulated by a complex system of hormones and cytokines that cause osteoblasts/stromal...
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis (with Meilheng Yang, Genevieve Mailhot, Mark J. Birnbaum, Carole A. MacKay, and April Mason-Savas), The Journal of biological chemistry (2006)
Osteoclasts differentiate from hematopoietic mononuclear precursor cells under the control of both colony stimulating factor-1...
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains (with Gary Toukatly, Peter Lawrence Bangs, Reid Gilmore, and Edward G. Fey), Journal of cell science (1996)
We have identified and characterized a human protein of the mitochondria which we call mitofilin....
In Situ Hybridization
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty (with Jian-ming Li, Xueqing Zhang, Peter R. Nelson, Janice D. Nelson, Calin A. Vasiliu, Jane Park, Marvin Morris, Jane B. Lian, Bruce S. Cutler, and Peter E. Newburger), Journal of cellular biochemistry (2007)
The success of vascular intervention including angioplasty, stenting, and arterial bypass remains limited by negative...
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (with Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, and Steven N. Popoff), The International journal of developmental biology (2000)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental...
Chemotaxis
Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9 (with Meilheng Yang), Cytokine (2005)
We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating...
Repressor Proteins
Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells (with Andre J. Van Wijnen, Cathleen L. Cooper, Farah Aziz, Antonio De Luca, A. Rauf Shakoori, Antonio Giordano, Peter J. Quesenberry, Jane B. Lian, Gary S. Stein, and Janet L. Stein), Journal of cellular biochemistry (1997)
The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the...
Signal Transduction
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis (with Nacksung Kim, Yuho Kadono, Masamichi Takami, Junwon Lee, Seoung-Hoon Lee, Fumihiko Okada, Jung Ha Kim, Takashi Kobayashi, Hiroyasu Nakano, Wen-Chen Yeh, Sun-Kyeong Lee, Joseph A. Lorenzo, and Yongwon Choi), The Journal of experimental medicine (2005)
Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic...
Chromosomes
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (with Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, and Sandy C. Marks Jr.), The International journal of developmental biology (2002)
The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required...
Cell Proliferation
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts (with John A. Arnott, E. Nuglozeh, Mario C. Rico, Israel Arango-Hisijara, Fayez F. Safadi, and Steven N. Popoff), Journal of cellular physiology (2006)
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as...
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro (with Meilheng Yang, Genevieve Mailhot, Carole A. MacKay, April Mason-Savas, and Justin Aubin), Blood (2005)
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte...