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Extract:We have been aware for decades – perhaps as a somewhat far-off theoretical problem –...
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Objective: To estimate the degree of scatter of reports of randomised trials and systematic reviews,...
This article deals with inconsistency of relative (rather than absolute) treatment effects in binary/dichotomous outcomes....
The most common reason for rating up the quality of evidence is a large effect....
Background: Acute sinusitis is a common reason for patients to seek primary care consultations. The...
Background:Valid and comparable measures of health outcomes are needed for clinical trials, studies on quality...
Background: Long-term use of benzodiazepines (BZDs) is common. Not only is such use ineffective, but...
The history of breast cancer screening is littered with controversy. With 10 trials spanning 4...
Background Research: Evidence is insufficient to change physicians’ behaviour. In 1996, Pathman developed a four...
This is the protocol for a review and there is no abstract. The objectives are...
Objective - To compare the strengths and limitations of cardiovascular risk scores available for clinicians...
Background: Although CD4 cell count monitoring is used to decide when to start antiretroviral therapy...
The considerable gap between what we know from research and what is done in clinical...
This article is the first of a series providing guidance for use of the Grading...
GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also...
BACKGROUND: The measurement of hemoglobin A1c (Hb A1c) is employed in monitoring of patients with...
Innovation is often regarded as uniformly positive. This paper shows that the role of innovation...
Extract:In Reply: Because of space constraints, some analyses we conducted had to be left out...
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Aims/hypothesis: Fenofibrate caused an acute, sustained plasma creatinine increase in the Fenofibrate Intervention and Event...
Background: Laboratory testing has increased dramatically over recent decades, which is a consequence particularly of...
Objective: To estimate the accuracy of monitoring cholesterol concentration for detecting non-adherence to lipid lowering...
This is the third and last article in the series about the Grading of Recommendations...
Extract: Although Caroline Klazen and colleagues acknowledge that the main drawback of their open-label trial...
Background: Self-monitoring is increasingly recommended as a method of managing cardiovascular disease. However, the design,...
Objective: To determine the cost-effectiveness of routine administration, irrespective of blood pressure (BP), of a...
OBJECTIVE To evaluate the optimal interval for rechecking A1C levels below the diagnostic threshold of...
Thirty years ago, and a quarter of a century after randomised trials had become widely...
BACKGROUND: N-of-1 trials test treatment effectiveness within an individual patient. OBJECTIVE: To assess (i) the...
Extract: The results of thousands of trials are never acted on because their published reports...
Context: Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated...
Objectives: To estimate the long-term true change variation ("signal") and short-term within-person variation ("noise") of...
Background: Diabetes imposes a substantial burden globally in terms of premature mortality, morbidity, and health...
Extract: Some conditions can be diagnosed correctly by the patient, but self diagnosis should always...
Background: When rates of uptake of other drugs differ between treatment arms in long-term trials,...
Objective: To evaluate whether systemic corticosteroids improve symptoms of sore throat in adults and children....
The GRADE approach to grading the quality of evidence and strength of recommendations provides a...
Background: Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect...
Background: Surgical removal of the tonsils, with or without adenoidectomy (adeno-/tonsillectomy), is a common ENT...
Background: Acute otitis media (AOM) is one of the most common diseases in early infancy...
Objectives: To assess the accuracy in diagnosing heart failure of clinical features and potential primary...
Background: Sore throat is a very common reason for people to present for medical care....
Background Near-patient testing has made self-monitoring of anticoagulation with warfarin feasible, and several trials have...
Objective To assess how well B-type natriuretic peptide (BNP) predicts prognosis in patients with heart...
Background: A variety of definitions of evidence-based practice (EBP) exist. However, definitions are in themselves...
The editorial discusses some elements of teaching and learning evidence based medicine. It comments on...
In March, 2003, the editor of The Lancet attended an international conference in Kingston, Ontario,...
This article considers the effects of interventions to reduce symptoms and complications of acute infective...
Background: Acute otitis media is one of the most common diseases in early infancy and...
This is the protocol for a review. The objective is as follows: 1. To determine...
Background The diagnosis of heart failure is difficult, with both overdiagnosis and underdiagnosis occurring commonly...
Objective: To measure the cost-effectiveness of cholesterol-lowering therapy with pravastatin in patients with established ischaemic...
Monitoring is a major component of management of chronic diseases such as diabetes, cardiovascular disease,...
Clinicians are taught masses of facts, but not how to use them in the messy...
Extract: This book is for clinicians at any stage of their training or career...
This attractive, full colour workbook provides a clear explanation of evidence-based medicine skills and concepts....
Decision making in health care involves navigating through a complex and tangled web of diagnostic...
What do we do if different studies appear to give different answers? When applying research...
[Excerpt] What we will do here is set out some models of disease, and then...