Taking healthcare interventions from trial to practice
Glasziou, P., Chalmers, I., Altman, D. G., Bastian, H., Boutron, I., Brice, A., Jamtvedt, G., Farmer, A., Ghersi, D., Groves, T., Heneghan, C., Hill, S., Lewin, S., Michie, S., Perera, R., Pomeroy, V., Tilson, J., Shepperd, S., & Williams, J. W. (2010). Taking healthcare interventions from trial to practice. BMJ, 341(c3852 ), 384-387.
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The results of thousands of trials are never acted on because their published reports do not describe the interventions in enough detail. How can we improve the reporting?
Much healthcare research is currently wasted because its findings are unusable.¹ Published reports of intervention trials often focus on the results and fail to describe interventions adequately. For example, a review of 80 studies selected for the journal Evidence Based Medicine as both valid and important for clinical practice found that clinicians could replicate the intervention in only half the studies.² Interventions may be used incorrectly or not at all if there is inadequate detail in the trial protocol, on the conduct of the trial, in systematic reviews and guidelines, and finally during implementation (fig 1⇓). This is an unnecessary but remediable waste, as we discuss below.
Paul Glasziou, Iain Chalmers, Douglas G. Altman, Hilda Bastian, Isabelle Boutron, Anne Brice, Gro Jamtvedt, Andrew Farmer, Davina Ghersi, Trish Groves, Carl Heneghan, Sophie Hill, Simon Lewin, Susan Michie, Rafael Perera, Valerie Pomeroy, Julie Tilson, Sasha Shepperd, and John W. Williams. "Taking healthcare interventions from trial to practice" BMJ 341.c3852 (2010): 384-387.
Available at: http://works.bepress.com/paul_glasziou/20