Unpublished Papers

pocrm: An R package for Phase I trials of combinations of agents

Nolan A. Wages, University of Virginia
Nikole Varhegyi, University of Virginia

Abstract

This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1,2]) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.

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