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Article
A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion
PLoS ONE
(2014)
Abstract
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
Disciplines
Publication Date
October 29, 2014
DOI
10.1371/journal.pone.0109361
Publisher Statement
© 2014 Sharma et al.
10.1371/journal.pone.0109361
Citation Information
Vijay Sharma, Jothilingam Sivapackiam, Scott E. Harpstrite, Julie L. Prior, et al.. "A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion" PLoS ONE Vol. 9 Iss. 10 (2014) p. 1 - 10 Available at: http://works.bepress.com/nigam-rath/345/
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