Articles

PDF

The Impact of Secondary Condom Interventions on the Interpretation of Results from HIV Prevention Trials (with Stephen Shiboski and Michael Rosenblum), Statistical Communications in Infectious Diseases (2010)

Given the recent failure of a number of randomized trials to demonstrate effectiveness of proposed...

 

PDF

Some Variants of the Backcalculation Method for Estimation of Disease Incidence: An Application to Multiple Sclerosis Data from the Faroe Islands (with Biao Wm. Lu), The International Journal of Biostatistics (2006)

Backcalculation is a technique that was originally developed for the study of HIV incidence. Here...

 

Books

Statistics for Epidemiology (2003)
 

Working Papers

PDF

A Machine-Learning Algorithm for Estimating and Ranking the Impact of Environmental Risk Factors in Exploratory Epidemiological Studies (with Jessica G. Young, Alan E. Hubbard, and B Eskenazi), U.C. Berkeley Division of Biostatistics Working Paper Series (2009)
 

PDF

Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)

This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...

 

PDF

Analyzing Direct Effects in Randomized Trials with Secondary Interventions (with Michael Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)

The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized...

 

PDF

Regression Analysis of a Disease Onset Distribution Using Diagnosis Data (with Jessica G. Young and Steven J. Samuels), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)

We consider methods for estimating the effect of a covariate on a disease onset distribution...

 

PDF

Nonparametric Estimation of the Case Fatality Ratio with Competing Risks Data: An Application to Severe Acute Respiratory Syndome (SARS) (with Xiudong Lei, A. C. Ghani, C. A. Donnelly, G. M. Leung, L. M. Ho, B. Cowling, and A. J. Hedley), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)

For diseases with some level of associated mortality, the case fatality ratio measures the proportion...

 

PDF

MAXIMUM LIKELIHOOD ESTIMATION OF ORDERED MULTINOMIAL PARAMETERS (with Jack Kalbfleisch), The University of Michigan Department of Biostatistics Working Paper Series (2003)

The pool-adjacent violator-algorithm (Ayer et al., 1955) has long been known to give the maximum...

 

Other

PDF

Correspondences between Regression Models for Complex Binary Outcomes and Those for Structured Multivariate Survival Analyses, U.C. Berkeley Division of Biostatistics Working Paper Series (2005)

Doksum and Gasko [5] described a one-to-one correspondence between regression models for binary outcomes and...

 

PDF

Estimation of the Case Fatality Ratio with Competing Risks Data: An Application to Severe Acute Respiratory Syndome (SARS) (with Xiudong Lei, A. C. Ghani, C. A. Donnelly, G. M. Leung, L. M. Ho, B. Cowling, and A. J. Hedley), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)

For diseases with some level of associated mortality, the case fatality ratio measures the proportion...

 

PDF

Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Mark J. van der Laan and Stephen Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)

Optimal designs of dose levels in order to estimate parameters from a model for binary...

 

PDF

Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Mark J. van der Laan and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)

We propose a class of estimators of the treatment effect on a dichotomous outcome among...

 

PDF

Temporal Stability and Geographic Variation in Cumulative Case Fatality Rates and Average Doubling Times of SARS Epidemics (with Alison P. Galvani and Xiudong Lei), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)

We analyze temporal stability and geographic trends in cumulative case fatality rates and average doubling...

 

PDF

Accelerated Hazards Model: Method, Theory and Applications (with Ying Qing Chen and Jingrong Yang), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

In an accelerated hazards model, the hazard functions of a failure time are related through...

 

PDF

Case-Control Current Status Data (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

Current status observation on survival times has recently been widely studied. An extreme form of...

 

PDF

Bivariate Current Status Data (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

In many applications, it is often of interest to estimate a bivariate distribution of two...

 

PDF

Current Status Data: Review, Recent Developments and Open Problems (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

Researchers working with survival data are by now adept at handling issues associated with incomplete...

 

PDF

Inference for Proportional Mean Residual Life Model in the Presence of Censoring (with Ying Q. Chen), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

As a function of time t, mean residual life is defined as remaining life expectancy...

 

PDF

Maximum Likelihood Estimation of Ordered Multinomial Parameters (with John D. Kalbfleisch), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)

The pool-adjacent violator-algorithm (Ayer, et al., 1955) has long been known to give the maximum...

 
Nonparametric Estimation from Current Status Data with Competing Risks (with Mark J. van der Laan and Tanya Henneman), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)

A great deal of recent attention has focused on the estimation of survival distributions based...

 
Current Status and Right-Censored Data Structures When Observing a Marker at the Censoring Time (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)

We study nonparametric estimation with two types of data structures. In the first data structure...

 
On a General Class of Semiparametric Hazards Regression Models (with Ying Qing Chen), U.C. Berkeley Division of Biostatistics Working Paper Series (2000)

A general class of semiparametric hazards regression models for survival data is proposed and studied....

 
The NPMLE in the Uniform Doubly Censored Current Status Data Model (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (1999)

In biostatistical applications interest often focuses on the estimation of the distribution of time T...

 
Nonparametric Efficient Estimation with Current Status Data and Right-Censored Data Structures When Observing a Marker at the Censoring Time (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)

We study nonparametric estimation with two types of data structures. In the first data structure...

 
Efficient Estimation of the Lifetime and Disease Onset Distribution (with Mark J. van der Laan and Derick R. Peterson), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)

We study efficient nonparametric maximum likelihood estimation of the distribution of onset and lifetime associated...

 
Singly and Doubly Censored Current Status Data With Extensions to Multi-State Counting Processes (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (1996)

In estimation of a survival function, current status data arises when the only information available...

 
Backcalculation of Multiple Sclerosis Incidence Rates Based on Faroe Islands Data (with Biao Wm. Lu), U.C. Berkeley Division of Biostatistics Working Paper Series (1996)

To address the controversial hypothesis that multiple sclerosis is infectious, detailed analysis is performed on...

 
Singly and Doubly Censored Current Status Data: Estimation, Asymptotics and Regression (with Mark J. van der Laan and Peter J. Bickel), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

In biostatistical applications interest is often focused on the estimation of the distribution of time...

 
Generalizations of Current Status Data With Applications (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

In estimation of a survival function, current status data arises when the only information available...

 
Regression with Doubly Censored Current Status Data (with Daniel Rabinowitz), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

Data from settings in which an initiating event and a subsequent event occur in sequence...

 
Semi-Parametric Estimation of the Mean Trajectory of a Marker Using Data from a Prevalent Cohort (with Eric Vittinghoff and Hina M. Malani), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

In natural history studies of disease, the population mean trajectory of markers of disease progression...

 
Double Censoring and All That: Problems in Biostatistical Inference, U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

In many epidemiologic studies of Human Immunodeficiency Virus (HIV) disease, interest focuses on the distribution...

 
Non-Parametric Estimation and Doubly-Censored Data: General Ideas and Applications to AIDS, U.C. Berkeley Division of Biostatistics Working Paper Series (1993)

In many epidemiologic studies of human immunodeficiney virus (HIV) disease, interest focuses on the distribution...

 
Shaping the Future of Public Health: The Role of Biostatistics, U.C. Berkeley Division of Biostatistics Working Paper Series (1993)

Comments about the current place for the discipline of Biostatistics within Public Health (1993).

 
A Competing Risks Analysis of Presenting AIDS Diagnoses Trends (with Robert E. Fusaro and Peter Bacchetti), U.C. Berkeley Division of Biostatistics Working Paper Series (1993)

The proportions of gay men presenting with various AIDS diagnoses display temporal trends. For example,...

 
Nonparametric Estimation for a Form of Doubly Censored Data, with Application to Two Problems in AIDS (with Hina M. Malani and Eric Vittinghoff), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)

In many epidemiologic studies of human immunodeficiency virus (HIV) disease, interest focuses on the distribution...

 
Variances for Maximum Penalized Likelihood Estimates Obtained via the EM Algorithm (with Mark R. Segal and Peter Bacchetti), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)

We address the problem of providing variances for parameter estimates obtained under a penalized likelihood...

 
Backcalculation of HIV Infection Rates (with Peter Bacchetti and Mark R. Segal), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)

Backcalculation is an important method of reconstructing past rates of human immunodeficiency virus (HIV) infection...

 
Markers Models in Survival Analysis and Applications to Issues Associated with AIDS (with John D. Kalbfleisch), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)

Jewell and Kalbfleisch (1992) consider the use of marker processes for applications related to estimation...

 
Uncertainty About the Incubation Period of AIDS and its Impact on Backcalculation (with Peter R. Bacchetti and Mark R. Segal), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)

We analyze three sets of doubly-censored cohort data on incubation times, estimating incubation distributions using...

 
Estimating Patterns of CD4+ Lymphocyte Decline Using Data from a Prevalent Cohort of HIV Infected Individuals (with Eric Vittinghoff and Hina M. Malani), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)

In natural history studies of chronic disease, it is of interest to understand the evolution...

 
The Design and Analysis of Partner Studies of HIV Transmission (with Stephen C. Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

Common goals in epidemiologic studies of infectious diseases include identification of the infectious agent, description...

 
A Geometric Approach to Assess Bias Due to Omitted Covariates in Generalized Linear Models (with John M. Neuhaus), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

Misspecifying generalized linear models by omitting covariates associated with the response can result in seriously...

 
The Impact of Uncertainty in the AIDS Incubation Period on Reconstructions of the HIV Epidemic (with Peter Bacchetti, Mark R. Segal, and Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

Backcalculation is the primary method used to reconstruct past human immunodeficiency virus (HIV) infection rates,...

 
An Annotated Bibliography of Methods for Analyzing Correlated Categorical Data (with Mark Ashby, John M. Neuhaus, Walter W. Hauck, Peter Bacchetti, David C. Heilbron, Mark R. Segal, and Robert E. Fusaro), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

This paper provides an annotated bibliography of over 100 articles concerning methods for analyzing correlated...

 
A Framework for Consistent Prediction Rules Based on Markers (with Jens Perch Nielsen), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

Recently interest has developed regarding the statistical properties and uses of marker processes in the...

 
Comparing the Positive Jackknife with the Usual Jackknife, U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

The positive jackknife is a variant of the familiar jackknife technique which also provides estimators...

 
Marker Processes in Survival Analysis (with John D. Kalbfleisch), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)

In the development of many diseases there are often associated variables that continuously measure the...

 
Prevalent Cohort Models in Clinical Treatment Studies: An Analysis of Zidovudine Treatment Data (with Mei-Cheng Wang and Ron Brookmeyer), U.C. Berkeley Division of Biostatistics Working Paper Series (1990)

In prospective cohort studies individuals are sometimes recruited according to a certain cross-sectional sampling criterion....

 
Some Surprising Results About Covariate Adjustment in Logistic Regression Models (with Laurence D. Robinson), U.C. Berkeley Division of Biostatistics Working Paper Series (1990)

Results from classic linear regression regarding the effect of adjusting for covariates upon the precision...

 
Nonparametric Estimation of the Incubation Period of AIDS Based on a Prevalent Cohort with Unknown Infection Times (with Peter Bacchetti), U.C. Berkeley Division of Biostatistics Working Paper Series (1990)

Estimation of the incubation period distribution of Human Immunodeficiency Virus based on prevalent cohorts of...

 
Statistical Analysis of the Time Dependence of HIV Infectivity Based on Partner Study Data (with Stephen C. Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (1990)

Statistical analyses of data form studies of Human Immunodeficiency Virus (HIV) transmission in partners of...

 
Hypothesis Testing of Regression Parameters in Semi-Parametric Generalized Linear Models for Cluster Correlated Data (with Andrea Rotnitzky), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)

Generalized and "working" Wald and score tests for regression coefficients in the class of semi-parametric...

 
Some Statistical Issues in Studies of the Epidemiology of AIDS, U.C. Berkeley Division of Biostatistics Working Paper Series (1989)

Analyses of studies of the epidemiology and natural history of infection with the Human Immunodeficiency...

 
The Effect of Retrospective Sampling on Binary Regression Models for Clustered Data (with John M. Neuhaus), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)

Recently a great deal of attention has been given to binary regression models for clustered...

 
An Annotated Bibliography of Quantitative Methodology Relating to the AIDS Epidemic (with Robert E. Fusaro, Walter W. Hauck, David C. Heilbron, John D. Kalbfleisch, John M. Neuhaus, and Mark A. Ashby), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)

This paper provides an annotated bibliography of over 100 articles containing quantitative methodology relating to...

 
Some Comments on Rosner's Multiple Logistic Model for Clustered Data (with John M. Neuhaus and Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)

Rosner (1984, Biometrics 41, 1025-1035) proposed a binary regression model for analyzing binary response data...

 
Statistical Analysis of HIV Infectivity Based on Partner Studies (with Stephen C. Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)

Partner studies produce data on the infection status of partners of individuals known or assumed...