Nicholas P. Jewell is Professor of Biostatistics and Statistics at the University of California, Berkeley. He has held various academic and administrative positions at Berkeley since his arrival in 1981, most notably serving as Vice Provost from 1994 to 2000. He was educated at the University of Edinburgh where he received a first class Honours degree in Applied Mathematics in 1973 and a PhD in Mathematics in 1976. Immediately following his graduate program he was appointed to a Harkness Fellowship from 1976-1978 which he held at the University of California, Berkeley and at Stanford University. From 1979-1981 he was an Assistant Professor of Statistics at Princeton University. He has also held academic appointments at the University of Edinburgh, Oxford University, and at the University of Kyoto. In 2007, he was a Fellow at the Rockefeller Foundation Bellagio Study Center in Italy, He is a Fellow of the American Statistical Association, the Institute of Mathematical Statistics, and the American Association for the Advancement of Science (AAAS). He is the 2005 winner of the Snedecor Award from COPSS, and won the Distinguished Teaching Award from UC Berkeley's School of Public Health in 2004. In 2000, he was awarded the Director's Award from the Federal Emergency Management Agency for "extraordinary leadership and vision in implementing strategies that enhance the disaster resistance of the University of California, Berkeley, and universities throughout America"; in addition the 2005 Alfred E. Alquist Award was given to UC Berkeley's SAFER program that he launched and led for many years.
Categorical Data Analysis
Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Mark J. van der Laan and Stephen Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Optimal designs of dose levels in order to estimate parameters from a model for binary...
Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Mark J. van der Laan and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
MAXIMUM LIKELIHOOD ESTIMATION OF ORDERED MULTINOMIAL PARAMETERS (with Jack Kalbfleisch), The University of Michigan Department of Biostatistics Working Paper Series (2003)
The pool-adjacent violator-algorithm (Ayer et al., 1955) has long been known to give the maximum...
Some Surprising Results About Covariate Adjustment in Logistic Regression Models (with Laurence D. Robinson), U.C. Berkeley Division of Biostatistics Working Paper Series (1990)
Results from classic linear regression regarding the effect of adjusting for covariates upon the precision...
The Effect of Retrospective Sampling on Binary Regression Models for Clustered Data (with John M. Neuhaus), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)
Recently a great deal of attention has been given to binary regression models for clustered...
Clinical Trials
The Impact of Secondary Condom Interventions on the Interpretation of Results from HIV Prevention Trials (with Stephen Shiboski and Michael Rosenblum), Statistical Communications in Infectious Diseases (2010)
Given the recent failure of a number of randomized trials to demonstrate effectiveness of proposed...
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
Analyzing Direct Effects in Randomized Trials with Secondary Interventions (with Michael Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized...
Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Mark J. van der Laan and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
Computation
MAXIMUM LIKELIHOOD ESTIMATION OF ORDERED MULTINOMIAL PARAMETERS (with Jack Kalbfleisch), The University of Michigan Department of Biostatistics Working Paper Series (2003)
The pool-adjacent violator-algorithm (Ayer et al., 1955) has long been known to give the maximum...
Bivariate Current Status Data (with Mark J. van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In many applications, it is often of interest to estimate a bivariate distribution of two...
Maximum Likelihood Estimation of Ordered Multinomial Parameters (with John D. Kalbfleisch), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
The pool-adjacent violator-algorithm (Ayer, et al., 1955) has long been known to give the maximum...
Variances for Maximum Penalized Likelihood Estimates Obtained via the EM Algorithm (with Mark R. Segal and Peter Bacchetti), U.C. Berkeley Division of Biostatistics Working Paper Series (1992)
We address the problem of providing variances for parameter estimates obtained under a penalized likelihood...
Disease Modeling
Some Variants of the Backcalculation Method for Estimation of Disease Incidence: An Application to Multiple Sclerosis Data from the Faroe Islands (with Biao Wm. Lu), The International Journal of Biostatistics (2006)
Backcalculation is a technique that was originally developed for the study of HIV incidence. Here...
Estimation of the Case Fatality Ratio with Competing Risks Data: An Application to Severe Acute Respiratory Syndome (SARS) (with Xiudong Lei, A. C. Ghani, C. A. Donnelly, G. M. Leung, L. M. Ho, B. Cowling, and A. J. Hedley), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
For diseases with some level of associated mortality, the case fatality ratio measures the proportion...
Temporal Stability and Geographic Variation in Cumulative Case Fatality Rates and Average Doubling Times of SARS Epidemics (with Alison P. Galvani and Xiudong Lei), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
We analyze temporal stability and geographic trends in cumulative case fatality rates and average doubling...
Efficient Estimation of the Lifetime and Disease Onset Distribution (with Mark J. van der Laan and Derick R. Peterson), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)
We study efficient nonparametric maximum likelihood estimation of the distribution of onset and lifetime associated...
Backcalculation of Multiple Sclerosis Incidence Rates Based on Faroe Islands Data (with Biao Wm. Lu), U.C. Berkeley Division of Biostatistics Working Paper Series (1996)
To address the controversial hypothesis that multiple sclerosis is infectious, detailed analysis is performed on...
Epidemiology
A Machine-Learning Algorithm for Estimating and Ranking the Impact of Environmental Risk Factors in Exploratory Epidemiological Studies (with Jessica G. Young, Alan E. Hubbard, and B Eskenazi), U.C. Berkeley Division of Biostatistics Working Paper Series (2009)
Some Variants of the Backcalculation Method for Estimation of Disease Incidence: An Application to Multiple Sclerosis Data from the Faroe Islands (with Biao Wm. Lu), The International Journal of Biostatistics (2006)
Backcalculation is a technique that was originally developed for the study of HIV incidence. Here...
Estimation of the Case Fatality Ratio with Competing Risks Data: An Application to Severe Acute Respiratory Syndome (SARS) (with Xiudong Lei, A. C. Ghani, C. A. Donnelly, G. M. Leung, L. M. Ho, B. Cowling, and A. J. Hedley), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
For diseases with some level of associated mortality, the case fatality ratio measures the proportion...
Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Mark J. van der Laan and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
Temporal Stability and Geographic Variation in Cumulative Case Fatality Rates and Average Doubling Times of SARS Epidemics (with Alison P. Galvani and Xiudong Lei), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
We analyze temporal stability and geographic trends in cumulative case fatality rates and average doubling...
General Biostatistics
A Machine-Learning Algorithm for Estimating and Ranking the Impact of Environmental Risk Factors in Exploratory Epidemiological Studies (with Jessica G. Young, Alan E. Hubbard, and B Eskenazi), U.C. Berkeley Division of Biostatistics Working Paper Series (2009)
Statistics for Epidemiology (2003)
Institutional and Historical
Shaping the Future of Public Health: The Role of Biostatistics, U.C. Berkeley Division of Biostatistics Working Paper Series (1993)
Comments about the current place for the discipline of Biostatistics within Public Health (1993).
Longitudinal Data Analysis and Time Series
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
An Annotated Bibliography of Methods for Analyzing Correlated Categorical Data (with Mark Ashby, John M. Neuhaus, Walter W. Hauck, Peter Bacchetti, David C. Heilbron, Mark R. Segal, and Robert E. Fusaro), U.C. Berkeley Division of Biostatistics Working Paper Series (1991)
This paper provides an annotated bibliography of over 100 articles concerning methods for analyzing correlated...
Hypothesis Testing of Regression Parameters in Semi-Parametric Generalized Linear Models for Cluster Correlated Data (with Andrea Rotnitzky), U.C. Berkeley Division of Biostatistics Working Paper Series (1989)
Generalized and "working" Wald and score tests for regression coefficients in the class of semi-parametric...
Statistical Models
Correspondences between Regression Models for Complex Binary Outcomes and Those for Structured Multivariate Survival Analyses, U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Doksum and Gasko [5] described a one-to-one correspondence between regression models for binary outcomes and...
Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Mark J. van der Laan and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
Accelerated Hazards Model: Method, Theory and Applications (with Ying Qing Chen and Jingrong Yang), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In an accelerated hazards model, the hazard functions of a failure time are related through...
Inference for Proportional Mean Residual Life Model in the Presence of Censoring (with Ying Q. Chen), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
As a function of time t, mean residual life is defined as remaining life expectancy...
On a General Class of Semiparametric Hazards Regression Models (with Ying Qing Chen), U.C. Berkeley Division of Biostatistics Working Paper Series (2000)
A general class of semiparametric hazards regression models for survival data is proposed and studied....
Statistical Theory and Methods
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
Some Variants of the Backcalculation Method for Estimation of Disease Incidence: An Application to Multiple Sclerosis Data from the Faroe Islands (with Biao Wm. Lu), The International Journal of Biostatistics (2006)
Backcalculation is a technique that was originally developed for the study of HIV incidence. Here...
Correspondences between Regression Models for Complex Binary Outcomes and Those for Structured Multivariate Survival Analyses, U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Doksum and Gasko [5] described a one-to-one correspondence between regression models for binary outcomes and...
Estimation of the Case Fatality Ratio with Competing Risks Data: An Application to Severe Acute Respiratory Syndome (SARS) (with Xiudong Lei, A. C. Ghani, C. A. Donnelly, G. M. Leung, L. M. Ho, B. Cowling, and A. J. Hedley), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
For diseases with some level of associated mortality, the case fatality ratio measures the proportion...
Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Mark J. van der Laan and Stephen Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Optimal designs of dose levels in order to estimate parameters from a model for binary...
Survival Analysis
Regression Analysis of a Disease Onset Distribution Using Diagnosis Data (with Jessica G. Young and Steven J. Samuels), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
We consider methods for estimating the effect of a covariate on a disease onset distribution...
Correspondences between Regression Models for Complex Binary Outcomes and Those for Structured Multivariate Survival Analyses, U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Doksum and Gasko [5] described a one-to-one correspondence between regression models for binary outcomes and...
Nonparametric Estimation of the Case Fatality Ratio with Competing Risks Data: An Application to Severe Acute Respiratory Syndome (SARS) (with Xiudong Lei, A. C. Ghani, C. A. Donnelly, G. M. Leung, L. M. Ho, B. Cowling, and A. J. Hedley), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
For diseases with some level of associated mortality, the case fatality ratio measures the proportion...
Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Mark J. van der Laan and Stephen Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Optimal designs of dose levels in order to estimate parameters from a model for binary...
MAXIMUM LIKELIHOOD ESTIMATION OF ORDERED MULTINOMIAL PARAMETERS (with Jack Kalbfleisch), The University of Michigan Department of Biostatistics Working Paper Series (2003)
The pool-adjacent violator-algorithm (Ayer et al., 1955) has long been known to give the maximum...
Clinical trials
The Impact of Secondary Condom Interventions on the Interpretation of Results from HIV Prevention Trials (with Stephen Shiboski and Michael Rosenblum), Statistical Communications in Infectious Diseases (2010)
Given the recent failure of a number of randomized trials to demonstrate effectiveness of proposed...
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
Analyzing Direct Effects in Randomized Trials with Secondary Interventions (with Michael Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized...
Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Mark J. van der Laan and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
Causal methods
The Impact of Secondary Condom Interventions on the Interpretation of Results from HIV Prevention Trials (with Stephen Shiboski and Michael Rosenblum), Statistical Communications in Infectious Diseases (2010)
Given the recent failure of a number of randomized trials to demonstrate effectiveness of proposed...
A Machine-Learning Algorithm for Estimating and Ranking the Impact of Environmental Risk Factors in Exploratory Epidemiological Studies (with Jessica G. Young, Alan E. Hubbard, and B Eskenazi), U.C. Berkeley Division of Biostatistics Working Paper Series (2009)
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
Analyzing Direct Effects in Randomized Trials with Secondary Interventions (with Michael Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized...
Design of Experiments and Sample Surveys
The Impact of Secondary Condom Interventions on the Interpretation of Results from HIV Prevention Trials (with Stephen Shiboski and Michael Rosenblum), Statistical Communications in Infectious Diseases (2010)
Given the recent failure of a number of randomized trials to demonstrate effectiveness of proposed...
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
Analyzing Direct Effects in Randomized Trials with Secondary Interventions (with Michael Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized...
HIV prevention
The Impact of Secondary Condom Interventions on the Interpretation of Results from HIV Prevention Trials (with Stephen Shiboski and Michael Rosenblum), Statistical Communications in Infectious Diseases (2010)
Given the recent failure of a number of randomized trials to demonstrate effectiveness of proposed...
Detailed Version: Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials (with Michael A. Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized...
Analyzing Direct Effects in Randomized Trials with Secondary Interventions (with Michael Rosenblum, Mark J. van der Laan, Stephen Shiboski, Ariane van der Straten, and Nancy Padian), U.C. Berkeley Division of Biostatistics Working Paper Series (2007)
The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized...