Founded by Native American women in 1974, "Women of All Red Nations (WARN) insisted that the ongoing Indian public health crisis could not be properly understood exclusively within the context of the exploitation and pollution of the physical environment. It required as well an understanding of the larger context of Indian health issues evolving out of past and present cultural and political changes. This article focuses on selected health, threats affecting the Dine, or "the People," as Navajo Indians call themselves, living in Dine Bikeyah (Navajo Nation) during the mid to late 20th century. Navajo history is marked by a series of catastrophes befalling the health of its people and lands, and reactions by both the Dine and the federal government. The 20th century Navajo story combines the concurrent tragedies of forced Indian sterilizations with the calamitous health consequences of uranium exploitation that continue into the 21st century. This context must not be ignored when assessing the difficulties involved in establishing a trusting relationship between the Navajo people and outside researchers and health care providers.