Low Vitamin D Status is Associated with Physical Inactivity, Obesity and Low Vitamin D Intake in a Large US Sample of Healthy Middle-Aged Men and Women

K. Brock, University of Sydney
W. Y. Huang, National Cancer Institute - Maryland
D. R. Fraser, University of Sydney
L. Ke, The George Institute - Beijing
M. Tseng, California Polytechnic State University, San Luis Obispo
R. Stolzenberg-Solomon, National Cancer Institute - Maryland
U. Peters, Fred Hutchinson Cancer - Washington
J. Ahn, New York University School of Medicine
M. Purdue, National Cancer Institute - Maryland
R. S. Mason, University of Sydney
C. McCarty, Marshfield Clinic Research Foundation
R. G. Ziegler, National Cancer Institute - Maryland
B. Graubard, National Cancer Institute - Maryland

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Copyright © 2010 Elsevier. The definitive version is available at http://dx.doi.org/10.1016/j.jsbmb.2010.03.091.

Abstract

The aim of this study was to investigate modifiable predictors of vitamin D status in healthy individuals, aged 55–74, and living across the USA. Vitamin D status [serum 25-hydroxyvitamin D (25(OH)D)] was measured along with age and season at blood collection, demographics, anthropometry, physical activity (PA), diet, and other lifestyle factors in 1357 male and 1264 female controls selected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Multivariate linear and logistic regression analyses were used to identify associations with vitamin D status. Three%, 29% and 79% of the population had serum 25(OH)D levels <25, <50 and <80 nmol/L, respectively. The major modifiable predictors of low vitamin D status were low vitamin D dietary and supplement intake, body mass index (BMI) >30 kg/m², physical inactivity (PA) and low milk and calcium supplement intake. In men, 25(OH)D was determined more by milk intake on cereal and in women, by vitamin D and calcium supplement and menopausal hormone therapy (MHT) use. Thus targeting an increase in vigorous activity and vitamin D and calcium intake and decreasing obesity could be public health interventions independent of sun exposure to improve vitamin D status in middle-aged Americans.