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Article
Fludarabine induced autoimmune haemolytic anaemia in a patient with chronic lymphocytic leukaemia
Journal of Pakistan Medical Association
  • Naveen Naz Syed, Aga Khan University
  • Mohammad Khurshid, Aga Khan University
Publication Date
1-1-2006
Document Type
Article
Disciplines
Abstract

Autoimmune haemolytic anaemia following fludarabine is an uncommon complication and previously treated patients are at higher risk. We describe a case of 57- year old lady with chronic lymphocytic leukaemia; she received intermittent courses of alkylating agents and purine analogue, fludarabine. Reintroduction of fludarabine for her relapsing disease induced autoimmune haemolytic anaemia. Numbers of cases have been reported regarding autoimmune haemolytic anaemia following fludarabine administration, but none have been published from our part of the world. Normally T-cell suppresses autoreactive lymphocytes that can produce autoantibodies. Suppression of T-cells by fludarabine, in addition to the underlying disease process appears to be a contributory factor for autoimmune haemolytic anaemia.

Citation Information
Naveen Naz Syed and Mohammad Khurshid. "Fludarabine induced autoimmune haemolytic anaemia in a patient with chronic lymphocytic leukaemia" Journal of Pakistan Medical Association Vol. 56 Iss. 1 (2006) p. 44 - 45
Available at: http://works.bepress.com/mohammad_khurshid/44/