RESEARCH INTERESTS Developing new synthetic methodologies, with an emphasis in asymmetric organocatalysis and transition metal chemistry Natural product total synthesis Small molecule synthesis for probing biosynthetic enzymatic pathways
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BOTPPI, a New Wittig Salt Used in the Synthesis of 12-(S)-Hydroxy-Eicosatetraenoic Acid [12-(S)-HETE] (with M. B. Andrus), Tetrahedron Lett. (2011)
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743 (with C. M. Rath, B. Janto, J. Earl, A. Ahmed, F. A. Hu, L. Hiller, M. Dahlgren, R. Kreft, F. Yu, J. J. Wolff, H. K. Kweon, K. Hakansson, R. M. Williams, G. D. Ehrlich, and D. H. Sherman), ACS Chemical Biology (2011)
Synthesis of Substrates to Probe the Biochemistry of the Ecteinascidin 743 (ET-743) Biosynthetic Gene Cluster (with A. Jimenez-Somarribas, C. M. Rath, R. M. Williams, and D. H. Sherman), Organic & Biomolecular Chemistry (2011)
Phase-transfer catalyzed synthesis of the Soy isoflavanoid S-Equol (with A. W. Butler, A. L. Calvert, and M. B. Andrus), Phase-transfer catalyzed synthesis of the Soy isoflavanoid S-Equol (2009)
S-Equol is an isoflavanoid metabolized from the isoflavone daidzein by intestinal bacteria. Only 30-50 percent...
Synthesis of kurasoin B analogs (with J. R. Nielson and M. B. Andrus), Synthesis of kurasoin B analogs (2009)
Kurasoin B (1), isolated in 1996 by Uchida et al, selectively inhibits Farnesyltransferase (FTase), an...