Article
Modeling colorectal cancer as a 3-dimensional disease in a dish: the case for drug screening using organoids, zebrafish, and fruit flies
Drug Discovery Today: Technologies
(2013)
Abstract
This review discusses recent shifts in the understanding of colorectal cancer as a stem cell based disease, based on findings that tie patient prognosis to the presence of cancer stem cells in colorectal tumors. Currently no drugs specifically target CSCs in colorectal tumors. However, recent advances in the culturing of colorectal stem cells using mammalian organoids, zebrafish, and Drosophila offer promising avenues for anti-CSC drug discovery.
Keywords
- colorectal cancer,
- cancer stem cells,
- chemical screening,
- whole animal models
Disciplines
Publication Date
2013
Citation Information
Michele Markstein. "Modeling colorectal cancer as a 3-dimensional disease in a dish: the case for drug screening using organoids, zebrafish, and fruit flies" Drug Discovery Today: Technologies Vol. 10 Iss. 1 (2013) Available at: http://works.bepress.com/michele_markstein/9/