The following paper discusses the strengths and weaknesses of programs in Southeast Asia that focus on intra-national, regional, and international collaboration efforts and continuing professional development activities. The opportunities and threats to such programs are analyzed as well as their successful and unsuccessful strategies. The author provides a list of personal recommendations for success drawing on proven methods utilized elsewhere. Though the primary focus is on library professionals in Southeast Asian Countries ((Malaysia, Singapore, Indonesia, Thailand, Laos, Vietnam, Myanmar, the Philippines, Cambodia, and Brunei) some attention is paid to other Asian countries (China and India), as well as two African nations (Uganda and Kenya), and the United States. The conclusion of the paper couches the necessity of collaboration and continuing professional development as an integral part of a librarian’s education after graduation and calls for greater efforts to be made in achieving the success of such programs.