Increasingly, strategic flexibility has been viewed as a critical organizational competency that enables firms to achieve and maintain competitive advantage and superior performance. In this study, the relationship between IS support for strategic flexibility and the bottom-line performance of firms is investigated, as well as the moderating effects of environmental dynamism on that relationship. Using both survey and archival data, IS support for strategic flexibility was positively associated with profitability and labor productivity only when there was a high degree of environmental changes and uncertainty.