Objective: To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive...

Tetramethylenedisulfotetramine (tetramine; TETS) is a potent convulsant poison that is considered to be a chemical...

BACKGROUND AND PURPOSE Midazolam is a short-acting benzodiazepine that is widely used as an intravenous...

Propofol is a rapidly acting water-insoluble non-barbiturate anesthetic agent that is widely used as an...

Steroid 11β-hydroxylase (CYP11B1; EC 1.14.15.4) is a mitochondrial enzyme located in the zona fasciculata of...

The lung provides a portal of entry for drug delivery that could be used to...

Purpose: 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism...

Ganaxolone (3alpha-hydroxy-3alpha-methyl-5alpha-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator...

Purpose: Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA-A...

An acute brain insult such as traumatic head/brain injury, stroke, or an episode of status...

Topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] is a structurally novel antiepileptic drug that has broad efficacy in epilepsy,...

Convection-enhanced delivery (CED) permits the homogeneous distribution of therapeutic agents throughout localized regions of the...

BACKGROUND: Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet,...

The role of AMPA and GluR5-containing kainate receptors in the development and expression of amygdala...

Epileptic seizures occur as a result of episodic abnormal synchronous discharges in cerebral neuronal networks....

Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and hypersynchrony of brain neurons....

Perampanel [2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile; E2007] is a potent, selective, orally active non-competitive AMPA receptor antagonist developed...

The barbiturate phenobarbital has been in use in the treatment of epilepsy for 100 years....

In the 1990s there was intense interest in ionotropic glutamate receptors as therapeutic targets for...

Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and electroencephalographic (EEG)...

Convection-enhanced delivery (CED) is a novel drug-delivery technique that uses positive hydrostatic pressure to deliver...

Perimenstural catamenial epilepsy, the cyclical occurrence of seizure exacerbations near the time of menstruation, affects...

For the most part, resistance to medications in epilepsy is independent of the choice of...

Migraine and epilepsy are comorbid episodic disorders that have common pathophysiologic mechanisms. Migraine attacks, like...

Many currently prescribed antiepileptic drugs (AEDs) act via voltage-gated sodium channels, through effects on gamma-aminobutyric...

The ketogenic diet is a valuable therapeutic approach for epilepsy, one in which most clinical...

This review considers how recent advances in the physiology of ion channels and other potential...

The ketogenic diet has been in clinical use for over 80 years, primarily for the...

There is a remarkable array of new chemical entities in the current antiepileptic drug (AED)...

Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with epilepsy. The drugs...

Antiepileptic drugs (AEDs) are commonly prescribed for nonepileptic conditions, including migraine headache, chronicneuropathic pain, mood...

Pharmacoresistance to antiepileptic drugs (AEDs) is a barrier to seizure freedom for many persons with...

Currently, sponsors are not required to report the outcomes of clinical research on drugs or...

Overview of articles published in a special issue of Neurotherapeutics (April 2009) on nontraditional (non-drug)...

Levetiracetam, the alpha-ethyl analogue of the nootropic piracetam, is a widely used antiepileptic drug (AED)...

Migraine and epilepsy are episodic disorders that share many clinical features and underlying pathophysiological mechanisms....

Certain steroid hormone metabolites that have activity as modulators of GABA-A receptors but lack conventional...

In the past several years, there have been important advances in the clinical epidemiology of...

Prepared for the 16th International Headache Research Seminar, “Innovative Drug Development For Headache Disorders,” March...

Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which...

In this autobiography and collection of essays, we learn how Harold Varmus created a life...

Review of "Neurosteroids: A New Regulatory Function in the Nervous System" (edited by Etiene-Emile Baulieu,...