I am professor in the Department of Neurology at the University of California, Davis
School of Medicine. I am also a member of the UC Davis Center for Neuroscience and the
Pharmacology and Toxicology Graduate Group. I received a B.A. (biophysics) from Amherst
College, and M.D. and Ph.D. (pharmacology) degrees from Yale University. I was a
resident, fellow and assistant professor in the Department of Neurology at the Johns
Hopkins University School of Medicine. For over 20 years, I was a senior investigator and
chief of the Epilepsy Research Section at the National Institute of Neurological
Disorders and Stroke. My research interests involve ion channel pharmacology and
neurological therapeutics, including antiepileptic drugs and other epilepsy treatment
approaches. I am past president of the American Society for Experimental
NeuroTherapeutics. [Electronic versions of publications are provided to ensure timely
dissemination of academic work for noncommercial purposes. Copyright resides with the
respective copyright holders as stated in each article.] 

Original Research

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Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons (with Chao-Yin Chen, Lucas Matt, and Johannes Wilhelm Hell), Plos ONE (2014)

Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a...

 

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Role of GluK1 Kainate Receptors in Seizures, Epileptic Discharges, and Epileptogenesis (with Brita Fritsch, Janine Reis, Maciej Gasior, and Rafal M. Kaminski), Journal of Neuroscience (2014)

Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in...

 

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Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms (with Dorota Zolkowska, Ashish Dhir, Kathiresan Krishnan, and Douglas F. Covey), Psychopharmacology (Berl) (2014)

RATIONALE: Androsterone [(3α,5α)-3-hydroxyandrostan-17-one; 5α,3α-A] and its 5β-epimer etiocholanolone [(3α,5β)-3-hydroxyandrostan-17-one; 5β,3α-A)], the major excreted metabolites of...

 

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Proconvulsant Actions of Intrahippocampal Botulinum Neurotoxin B in the Rat (with Sonja Bröer, Dorota Zolkowska, and Manuela Gernert), Neuroscience (2013)

Botulinum neurotoxins (BoNTs) may affect the excitability of brain circuits by inhibiting neurotransmitter release at...

 

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Seizure protection by intrapulmonary delivery of midazolam in mice (with Ashish Dhir and Dorota Zolkowska), Neuropharmacology (2013)

The lung provides a portal of entry that could be used to rapidly deliver anticonvulsant...

 

Reviews

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The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments (with Rafal M. Kaminski and Henrik Klitgaard), Neurotherapeutics (2014)

A major goal of contemporary epilepsy research is the identification of therapies to prevent the...

 

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Epilepsy Therapy Development: Technical and Methodologic Issues in Studies with Animal Models (with Aristea S. Galanopoulou, Merab Kokaia, Jeffrey A. Loeb, Astrid Nehlig, Asla Pitkanen, Kevin J. Staley, Vicky H. Whittemore, and F. Edward Dudek), Epilepsia (2013)

The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This...

 

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Issues related to development of new antiseizure treatments (with Tracy Dixon-Salazar, Graeme J. Sills, Elinor Ben-Menachem, H. Steve White, Roger J. Porter, Marc A. Dichter, Solomon L. Moshe, Jeffrey L. Noebels, and Michael D. Privitera), Epilepsia (2013)

This report represents a summary of the discussions led by the antiseizure treatment working group...

 

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AMPA receptors as a molecular target in epilepsy therapy, Acta Neurol Scand (2013)

Epileptic seizures occur as a result of episodic abnormal synchronous discharges in cerebral neuronal networks....

 

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Glia and epilepsy: excitability and inflammation (with Orrin Devinsky, Annamaria Vezzani, Souhel Najjar, and Nihal C. De Lanerolle), Trends in Neurosciences (2013)

Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and hypersynchrony of brain neurons....

 

Commentaries and Editorials

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The Intrinsic Severity Hypothesis of Pharmacoresistance to Antiepileptic Drugs, Epilepsia (2013)

Pharmacoresistance to antiepileptic drugs (AEDs) is a barrier to seizure freedom for many persons with...

 

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Disclosure of Clinical Trial Results When Product Development Is Abandoned (with Howard J. Federoff), Sci Transl Med (2011)

Currently, sponsors are not required to report the outcomes of clinical research on drugs or...

 

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Nontraditional Epilepsy Treatment Approaches (with Gregory L. Holmes), Neurotherapeutics (2009)

Overview of articles published in a special issue of Neurotherapeutics (April 2009) on nontraditional (non-drug)...

 

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Brivaracetam: a rational drug discovery success story, Brit J Pharmacol (2008)

Levetiracetam, the alpha-ethyl analogue of the nootropic piracetam, is a widely used antiepileptic drug (AED)...

 

Book Chapters

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Tetramethylenedisulfotetramine (with Dongren Yang and Pamela J. Lein), Encyclopedia of Toxicology, 3rd edition (2014)

Tetramethylenedisulfotetramine (2,6-dithia-1,3,5,7-tetraazadamantane,2,2,6,6-tetraoxide, TETS) is a highly toxic heteroadamantane rodenticide. It is an odorless, tasteless,white crystalline...

 

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Mechanisms of Action of Antiseizure Drugs (Chapter 39) (with Roger J. Porter, Ashish Dhir, and Robert L. Macdonald), Handbook of Clinical Neurology, Epilepsy, Part II (2012)
 

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Migraine and Epilepsy—Shared Mechanisms within the Family of Episodic Disorders, Jasper’s Basic Mechanisms of the Epilepsies, 4th Edition (2012)

Migraine and epilepsy are episodic disorders that share many clinical features and underlying pathophysiological mechanisms....

 

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Neurosteroids—Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy (with Doodipala S. Reddy), Jasper’s Basic Mechanisms of the Epilepsies, 4th Edition (2012)

Certain steroid hormone metabolites that have activity as modulators of GABA-A receptors but lack conventional...

 

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What Clinical Observations on the Epidemiology of Antiepileptic Drug Intractability Tell Us About the Mechanisms of Pharmacoresistance, Puzzling Cases of Epilepsy. Second Edition (2008)

In the past several years, there have been important advances in the clinical epidemiology of...

 

Book Reviews

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The Art and Politics of Science (book review), Perspectives in Biology and Medicine (2009)

In this autobiography and collection of essays, we learn how Harold Varmus created a life...

 

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Of Blind Men and Brain Steroids, Trends in Pharmacological Sciences (2000)

Review of "Neurosteroids: A New Regulatory Function in the Nervous System" (edited by Etiene-Emile Baulieu,...