Students today face a daily explosion of information resources and the challenge of using these resources effectively and responsibly. Information literacy instruction (ILI) requires a shift in focus from teaching specific information resources to a set of critical thinking skills involving the use of information. ILI in an academic setting includes a variety of instructional approaches, such as course-related library instruction sessions, course-integrated projects, online tutorials, and stand-alone courses. Those running formal ILI programs consider curricular objectives, invoking combinations of instructional solutions over a period of time. This ERIC Digest examines characteristics of successful programs, presents specific examples of approaches currently being undertaken by academic libraries to support ILI, and addresses common challenges in developing and maintaining ILI programs. (Contains 28 references.)