Contribution to Book
Dendritic Cell Maturation Versus Polarization in Tumor Escape
Dendritic Cells in Cancer
(2008)
Abstract
Dendritic cells serve as key immunosurveillance agents throughout the body and orchestrate the coordinate innate and adaptive immune responses to antigenically complex cells and organisms that challenge the host. The ability of dendritic cells to promote beneficial versus irrelevant or even, counterproductive, immunity in the cancer setting depends to a large degree on the operational parameters displayed by the heterogeneous population of dendritic cells found in the tumor microenvironment. This chapter will discuss how tumors manipulate the state of maturation and type of functional polarization displayed by dendritic cells in order to affect immune escape.
Disciplines
Publication Date
2008
Editor
Michael R. Shurin, Russell D. Salter
Publisher
Springer Science+Business Media, LLC
DOI
10.1007/978-0-387-88611-4_18
Citation Information
Michael Lipscomb, Walter J Storkus and Amy K Wesa. "Dendritic Cell Maturation Versus Polarization in Tumor Escape" New York, NYDendritic Cells in Cancer (2008) p. 257 - 268 Available at: http://works.bepress.com/michael-lipscomb/2/