Effects of trimethoprim-sulfadiazine on thyroid function of horses
Trimethoprim-sulfadiazine was administered to horses in a randomized, placebo controlled study to determine the effects of potentiated sulfonamides on thyroid function in normal horses. The treatment group included eight horses that received trimethoprim-sulfadiazine mixed with molasses orally at 30 mg/kg once daily for eight weeks. The control group included 8 horses that received an oral placebo (flour mixed with molasses) once daily for the same period. Thyroid function was evaluated prior to initiation of treatment and after 8 weeks of treatment. Serum concentrations of total and free triiodothyronine (T3), total and free thyroxine (T4), and thyroid stimulating hormone (TSH) were determined at rest and after a thyrotropin-releasing hormone (TRH) stimulation test. There was no detectable difference between treatment and control groups.
C M. Rothschild, Melissa T. Hines, B Breuhaus, J Gay, and D C. Sellon. "Effects of trimethoprim-sulfadiazine on thyroid function of horses" Journal of Veterinary Internal Medicine 18.3 (2004): 370-373.
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