Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. (with T E. Kimura, A Duggirala, C C. Hindmarch, R C. Hewer, A C. Newby, and M Bond), Journal of molecular and cellular cardiology (2014)

AIMS: Cyclic AMP inhibits vascular smooth muscle cell (VSMC) proliferation which is important in the...



Lysophosphatidic acid induces increased BACE1 expression and Abeta formation (with J. Shi, Y. Dong, and X. Xu), BBA - Molecular Basis of Disease (2013)

The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor...



PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins (with Ting Li, L. Zeng, W. Gao, X. Fu, and X. Xu), Biochim Biophys Acta- Molecular Basis of Disease (2013)

Presenilin-associated protein (PSAP) has been identified as a mitochondrial proapoptotic protein. However, the mechanism by...



Death Receptor 6 Induces Apoptosis Not through Thype I or Type II Pathways, but via a Unique Mitochondria-dependent Pathway by Interacting with Bax Protein (with L. Zeng, T. Li, DC Xu, J. Liu, X. Fu, and X. Xu), Journal of Biological Chemistry (2012)

Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor pathway) and the...



Histamine induces activation of protein kinase D that mediates tissue factor expression and activity in human aortic smooth muscle cells (with F. Hao, D. Wu, and X. Xu), American Journal of Physiology-Heart and Circulatory Physiology (2012)

Histamine, an inflammatory mediator, has been shown to influence the pathogenesis of vascular wall cells....



Lysophosphatidic Acid, Tissue Factor and Atherosclerosis (invited commentary) (with Xuemin Xu), Xuemin Xu (2003)