Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. (with T E. Kimura, A Duggirala, C C. Hindmarch, R C. Hewer, A C. Newby, and M Bond), Journal of molecular and cellular cardiology (2014)

AIMS: Cyclic AMP inhibits vascular smooth muscle cell (VSMC) proliferation which is important in the...



Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration (with D D. Wu, F Zhang, F Hao, J Chun, and X Xu), The Journal of Biological Chemistry (2014)

Lysophosphatidic acid (LPA), a potent bioactive lipid found in atherosclerotic lesions, markedly induces smooth muscle...



Lysophosphatidic acid induces increased BACE1 expression and Abeta formation (with J. Shi, Y. Dong, and X. Xu), BBA - Molecular Basis of Disease (2013)

The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor...



PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins (with Ting Li, L. Zeng, W. Gao, X. Fu, and X. Xu), Biochim Biophys Acta- Molecular Basis of Disease (2013)

Presenilin-associated protein (PSAP) has been identified as a mitochondrial proapoptotic protein. However, the mechanism by...



Death Receptor 6 Induces Apoptosis Not through Thype I or Type II Pathways, but via a Unique Mitochondria-dependent Pathway by Interacting with Bax Protein (with L. Zeng, T. Li, DC Xu, J. Liu, X. Fu, and X. Xu), Journal of Biological Chemistry (2012)

Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor pathway) and the...



Lysophosphatidic Acid, Tissue Factor and Atherosclerosis (invited commentary) (with Xuemin Xu), Xuemin Xu (2003)