A large family of developmentally regulated cell wall structural proteins, the
extensins- a subgroup of hydroxyproline-rich glycoproteins, is the current focus of
research in my lab. Our work is directed towards understanding the role of extensins in
wall assembly and in particular how they contribute to the correct positioning of the
cell plate during cytokinesis. The plant cell wall is an extracellular matrix with
dynamic properties comprising three polymeric networks: cellulosic, pectic and structural
glycoproteins. The properties of this self-assembling supermolecular structure arise from
its correct assembly, a process about which we know almost nothing.
To place this research in context, it is part of a long-term and far-reaching goal to
identify the critical players in plant cell division and cell growth. These processes are
continuous throughout the life cycle of a plant; they are punctuated by cell
differentiation during cytokinesis, the final stage of cell division. Differentiation
usually begins when a cell divides to produce two cells, each different from the other in
size, shape and/or contents. Appropriately differentiated cells, growing and working in
concert, result in the plant’s architecture, size, shape, color, longevity, and ability
to function. To ‘build a plant’ many different molecular events must take place in the
cell to ensure that the required molecules are synthesized, processed and delivered to
‘construction sites’ where and when they are required. The plant cell wall is an
exquisite example of the end result of such a complex series of regulated events. There
are approximately 40 cell types in the model plant Arabidopsis, each with a ‘tailor-made’
wall in constant flux allowing the plant to develop an
