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A Method to Increase the Power of Multiple Testing Procedures Through Sample Splitting (with Daniel Rubin and Sandrine Dudoit), Statistical Applications in Genetics and Molecular Biology (2006)
Consider the standard multiple testing problem where many hypotheses are to be tested, each hypothesis...
 

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A Method to Increase the Power of Multiple Testing Procedures Through Sample Splitting (with Daniel Rubin and Sandrine Dudoit), Statistical Applications in Genetics and Molecular Biology (2006)
Consider the standard multiple testing problem where many hypotheses are to be tested, each hypothesis...
 

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Application of a Variable Importance Measure Method (with Merrill D. Birkner), The International Journal of Biostatistics (2006)
van der Laan (2005) proposed a targeted method used to construct variable importance measures coupled...
 

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Asymptotic Optimality of Likelihood-Based Cross-Validation (with Sandrine Dudoit and Sunduz Keles), Statistical Applications in Genetics and Molecular Biology (2006)
Likelihood-based cross-validation is a statistical tool for selecting a density estimate based on n i.i.d....
 

OpenURL

Asymptotic Optimality of Likelihood-Based Cross-Validation (with Sandrine Dudoit and Sunduz Keles), Statistical Applications in Genetics and Molecular Biology (2006)
Likelihood-based cross-validation is a statistical tool for selecting a density estimate based on n i.i.d....
 

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Augmentation Procedures for Control of the Generalized Family-Wise Error Rate and Tail Probabilities for the Proportion of False Positives (with Sandrine Dudoit and Katherine S. Pollard), Statistical Applications in Genetics and Molecular Biology (2006)
This article shows that any single-step or stepwise multiple testing procedure (asymptotically) controlling the family-wise...
 

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Augmentation Procedures for Control of the Generalized Family-Wise Error Rate and Tail Probabilities for the Proportion of False Positives (with Sandrine Dudoit and Katherine S. Pollard), Statistical Applications in Genetics and Molecular Biology (2006)
This article shows that any single-step or stepwise multiple testing procedure (asymptotically) controlling the family-wise...
 

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Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Nicholas P. Jewell and Stephen Shiboski), The International Journal of Biostatistics (2006)
Optimal designs of dose levels in order to estimate parameters from a model for binary...
 

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Cross-Validated Bagged Prediction of Survival (with Sandra E. Sinisi and Romain Neugebauer), Statistical Applications in Genetics and Molecular Biology (2006)
In this article, we show how to apply our previously proposed Deletion/Substitution/Addition algorithm in the...
 

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Deletion/Substitution/Addition Algorithm in Learning with Applications in Genomics (with Sandra E. Sinisi), Statistical Applications in Genetics and Molecular Biology (2006)
van der Laan and Dudoit (2003) provide a road map for estimation and performance assessment...
 

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Empirical Bayes and Resampling Based Multiple Testing Procedure Controlling Tail Probability of the Proportion of False Positives. (with Merrill D. Birkner and Alan E. Hubbard), Statistical Applications in Genetics and Molecular Biology (2006)
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a...
 

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Estimating a Survival Distribution with Current Status Data and High-dimensional Covariates (with Aad van der Vaart), The International Journal of Biostatistics (2006)
We consider the inverse problem of estimating a survival distribution when the survival times are...
 

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History-Adjusted Marginal Structural Models and Statically-Optimal Dynamic Treatment Regimens (with Maya L. Petersen and Marshall M. Joffe), The International Journal of Biostatistics (2006)
Marginal structural models (MSM) provide a powerful tool for estimating the causal effect of a...
 

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Issues of Processing and Multiple Testing of SELDI-TOF MS Proteomic Data (with Merrill D. Birkner, Alan E. Hubbard, Christine F. Skibola, Christine M. Hegedus, and Martyn T. Smith), Statistical Applications in Genetics and Molecular Biology (2006)
A new data filtering method for SELDI-TOF MS proteomic spectra data is described. We examined...
 

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Multiple Testing and Data Adaptive Regression: An Application to HIV-1 Sequence Data. (with Merrill D. Birkner and Sandra E. Sinisi), Statistical Applications in Genetics and Molecular Biology (2006)
Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological...
 

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Multiple Testing. Part I. Single-Step Procedures for Control of General Type I Error Rates (with Sandrine Dudoit and Katherine S. Pollard), Statistical Applications in Genetics and Molecular Biology (2006)
The present article proposes general single-step multiple testing procedures for controlling Type I error rates...
 

OpenURL

Multiple Testing. Part I. Single-Step Procedures for Control of General Type I Error Rates (with Sandrine Dudoit and Katherine S. Pollard), Statistical Applications in Genetics and Molecular Biology (2006)
The present article proposes general single-step multiple testing procedures for controlling Type I error rates...
 

OpenURL

Multiple Testing. Part II. Step-Down Procedures for Control of the Family-Wise Error Rate (with Sandrine Dudoit and Katherine S. Pollard), Statistical Applications in Genetics and Molecular Biology (2006)
The present article proposes two step-down multiple testing procedures for asymptotic control of the family-wise...
 

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Multiple Testing. Part II. Step-Down Procedures for Control of the Family-Wise Error Rate (with Sandrine Dudoit and Katherine S. Pollard), Statistical Applications in Genetics and Molecular Biology (2006)
The present article proposes two step-down multiple testing procedures for asymptotic control of the family-wise...
 

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Quantile-Function Based Null Distribution in Resampling Based Multiple Testing (with Alan E. Hubbard), Statistical Applications in Genetics and Molecular Biology (2006)
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a...
 

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Statistical Inference for Variable Importance, The International Journal of Biostatistics (2006)
Many statistical problems involve the learning of an importance/effect of a variable for predicting an...
 

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Supervised Detection of Regulatory Motifs in DNA Sequences (with Sunduz Keles, Sandrine Dudoit, Biao Xing, and Michael B. Eisen ), Statistical Applications in Genetics and Molecular Biology (2006)
Identification of transcription factor binding sites (regulatory motifs) is a major interest in contemporary biology....
 

OpenURL

Supervised Detection of Regulatory Motifs in DNA Sequences (with Sunduz Keles, Sandrine Dudoit, Biao Xing, and Michael B. Eisen ), Statistical Applications in Genetics and Molecular Biology (2006)
Identification of transcription factor binding sites (regulatory motifs) is a major interest in contemporary biology....
 

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Targeted Maximum Likelihood Learning (with Daniel Rubin), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)

Suppose one observes a sample of independent and identically distributed observations from a particular data...

 

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Diagnosing Bias in the Inverse Probability of Treatment Weighted Estimator Resulting from Violation of Experimental Treatment Assignment (with Yue Wang, Maya L. Petersen, and David Bangsberg), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
Inverse probability of treatment weighting (IPTW) is frequently used to estimate the causal effects of...
 

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Extending Marginal Structural Models through Local, Penalized, and Additive Learning (with Daniel Rubin), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)

Marginal structural models (MSMs) allow one to form causal inferences from data, by specifying a...

 

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Statistical Learning of Origin-Specific Statically Optimal Individualized Treatment Rules (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
Consider a longitudinal observational or controlled study in which one collects chronological data over time...
 

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Supervised Detection of Conserved Motifs in DNA Sequences with cosmo (with Oliver Bembom and Sunduz Keles), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)

Identification of transcription factor binding sites is a major interest in contemporary biological research. A...

 

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Doubly Robust Censoring Unbiased Transformations (with Daniel Rubin), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
We consider random design nonparametric regression when the response variable is subject to right censoring....
 

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A Method to Increase the Power of Multiple Testing Procedures Through Sample Splitting (with Daniel Rubin and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
Consider the standard multiple testing problem where many hypotheses are to be tested, each hypothesis...
 

A Method to Increase the Power of Multiple Testing Procedures Through Sample Splitting (with Daniel Rubin and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
Consider the standard multiple testing problem where many hypotheses are to be tested, each hypothesis...
 

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Individualized Treatment Rules: Generating Candidate Clinical Trials (with Maya L. Petersen and Steven G. Deeks), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
Statistical methods have rarely been applied to learn individualized treatment rules, or rules for altering...
 

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Super Learning: an Application to Prediction of HIV-1 Drug Susceptibility (with Sandra E. Sinisi and Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)
Many statistical methods exist that can be used to learn a predictor based on observed...
 

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Causal Effect Models for Intention to Treat and Realistic Individualized Treatment Rules, U.C. Berkeley Division of Biostatistics Working Paper Series (2006)

An important class of models in causal inference are the so-called marginal structural models which...

 

Multiple Tests of Association with Biological Annotation Metadata (with Sandrine Dudoit and Sunduz Keles), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)

We propose a general and formal statistical framework for the multiple tests of associations between...

 

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Multiple Tests of Association with Biological Annotation Metadata (with Sandrine Dudoit and Sunduz Keles), U.C. Berkeley Division of Biostatistics Working Paper Series (2006)

We propose a general and formal statistical framework for the multiple tests of associations between...

 

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History-Adjusted Marginal Structural Models to Estimate Time-Varying Effect Modification (with Maya L. Petersen, Steven G. Deeks, and Jeffrey N. Martin), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Much of epidemiology and clinical medicine is focused on the estimation of treatments or interventions...
 

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Issues of Processing and Multiple Testing of SELDI-TOF MS Proteomic Data (with Merrill D. Birkner, Alan E. Hubbard, Christine F. Skibola, Christine M. Hegedus, and Martyn T. Smith), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
A new data filtering method for SELDI-TOF MS proteomic spectra data is described. We examined...
 

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Quantile-Function Based Null Distribution in Resampling Based Multiple Testing (with Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a...
 

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Data Adaptive Pathway Testing (with Merrill D. Birkner and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
A majority of diseases are caused by a combination of factors, for example, composite genetic...
 

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Application of a Variable Importance Measure Method to HIV-1 Sequence Data (with Merrill D. Birkner), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
van der Laan (2005) proposed a method to construct variable importance measures and provided the...
 

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A General Imputation Methodology for Nonparametric Regression with Censored Data (with Dan Rubin), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
We consider the random design nonparametric regression problem when the response variable is subject to...
 

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Population Intervention Models in Causal Inference (with Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Marginal structural models (MSM) provide a powerful tool for estimating the causal effect of a]...
 

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Estimation of Direct Causal Effects (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Many common problems in epidemiologic and clinical research involve estimating the effect of an exposure...
 

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Cross-validated Bagged Prediction of Survival (with Sandra E. Sinisi), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
In this article, we show how to apply our previously proposed Deletion/Substitution/Addition algorithm in the...
 

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Direct Effect Models (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
The causal effect of a treatment on an outcome is generally mediated by several intermediate...
 

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Statistical Inference for Variable Importance, U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Many statistical problems involve the learning of an importance/effect of a variable for predicting an...
 

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Survival Point Estimate Prediction in Matched and Non-Matched Case-Control Subsample Designed Studies (with Annette M. Molinaro, Dan H. Moore, and Karla Kerlikowske), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)

Providing information about the risk of disease and clinical factors that may increase or...

 

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Application of a Multiple Testing Procedure Controlling the Proportion of False Positives to Protein and Bacterial Data (with Merrill D. Birkner and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Simultaneously testing multiple hypotheses is important in high-dimensional biological studies. In these situations, one is...
 

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Cross-Validating and Bagging Partitioning Algorithms with Variable Importance (with Annette M. Molinaro), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
We present a cross-validated bagging scheme in the context of partitioning algorithms. To explore the...
 

Test Statistics Null Distributions in Multiple Testing: Simulation Studies and Applications to Genomics (with Katherine S. Pollard, Merrill D. Birkner, and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)

Multiple hypothesis testing problems arise frequently in biomedical and genomic research, for instance, when identifying...

 

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Test Statistics Null Distributions in Multiple Testing: Simulation Studies and Applications to Genomics (with Katherine S. Pollard, Merrill D. Birkner, and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)

Multiple hypothesis testing problems arise frequently in biomedical and genomic research, for instance, when identifying...

 

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G-computation Estimation of Nonparametric Causal Effects on Time-Dependent Mean Outcomes in Longitudinal Studies (with Romain Neugebauer), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Two approaches to Causal Inference based on Marginal Structural Models (MSM) have been proposed. They...
 

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A Note on the Construction of Counterfactuals and the G-computation Formula (with Zhuo Yu), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Robins' causal inference theory assumes existence of treatment specific counterfactual variables so that the observed...
 

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Cross-validated Bagged Learning (with Sandra E. Sinisi and Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Many applications aim to learn a high dimensional parameter of a data generating distribution based...
 

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Estimating Function Based Cross-Validation and Learning (with Daniel Rubin), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Suppose that we observe a sample of independent and identically distributed realizations of a...
 

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Colon Cancer Prognosis Prediction by Gene Expression Profiling (with Alain Barrier and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Aims. This study assessed the possibility to build a prognosis predictor, based on microarray gene...
 

Colon Cancer Prognosis Prediction by Gene Expression Profiling (with Alain Barrier and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Aims. This study assessed the possibility to build a prognosis predictor, based on microarray gene...
 

Prognosis of Stage II Colon Cancer by Non-Neoplastic Mucosa Gene Expresssion Profiling (with Alain Barrier and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Aims. This study assessed the possibility to build a prognosis predictor, based on non-neoplastic mucosa...
 

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Prognosis of Stage II Colon Cancer by Non-Neoplastic Mucosa Gene Expresssion Profiling (with Alain Barrier and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Aims. This study assessed the possibility to build a prognosis predictor, based on non-neoplastic mucosa...
 

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Causal Inference in Longitudinal Studies with History-Restricted Marginal Structural Models (with Romain Neugebauer and Ira B. Tager), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Causal Inference based on Marginal Structural Models (MSMs) is particularly attractive to subject-matter investigators because...
 

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History-Adjusted Marginal Structural Models: Optimal Treatment Strategies (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Much of clinical medicine involves choosing a future treatment plan that is expected to optimize...
 

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History-Adjusted Marginal Structural Models: Time-Varying Effect Modification (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Marginal structural models (MSM) provide a powerful tool for estimating the causal effect of a...
 

Survival Ensembles (with Torsten Hothorn, Peter Buhlmann, Sandrine Dudoit, and Annette M. Molinaro), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
We propose a unified and flexible framework for ensemble learning in the presence of censoring....
 

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Survival Ensembles (with Torsten Hothorn, Peter Buhlmann, Sandrine Dudoit, and Annette M. Molinaro), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
We propose a unified and flexible framework for ensemble learning in the presence of censoring....
 

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Resampling Based Multiple Testing Procedure Controlling Tail Probability of the Proportion of False Positives (with Merrill D. Birkner and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a...
 

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Optimization of the Architecture of Neural Networks Using a Deletion/Substitution/Addition Algorithm (with Blythe Durbin and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Neural networks are a popular machine learning tool, particularly in applications such as the prediction...
 

Optimization of the Architecture of Neural Networks Using a Deletion/Substitution/Addition Algorithm (with Blythe Durbin and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Neural networks are a popular machine learning tool, particularly in applications such as the prediction...
 

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A Causal Inference Approach for Constructing Transcriptional Regulatory Networks (with Biao Xing), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
Transcriptional regulatory networks specify the interactions among regulatory genes and between regulatory genes and their...
 

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Cluster Analysis of Genomic Data with Applications in R (with Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
In this paper, we provide an overview of existing partitioning and hierarchical clustering algorithms in...
 

Multiple Testing Procedures and Applications to Genomics (with Merrill D. Birkner, Katherine S. Pollard, and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
This chapter proposes widely applicable resampling-based single-step and stepwise multiple testing procedures (MTP) for controlling...
 

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Multiple Testing Procedures and Applications to Genomics (with Merrill D. Birkner, Katherine S. Pollard, and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2005)
This chapter proposes widely applicable resampling-based single-step and stepwise multiple testing procedures (MTP) for controlling...
 

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Multiple Testing Procedures for Controlling Tail Probability Error Rates (with Sandrine Dudoit and Merrill D. Birkner), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The present article discusses and compares multiple testing procedures (MTP) for controlling Type I error...
 

Multiple Testing Procedures for Controlling Tail Probability Error Rates (with Sandrine Dudoit and Merrill D. Birkner), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The present article discusses and compares multiple testing procedures (MTP) for controlling Type I error...
 

Multiple Testing Procedures: R multtest Package and Applications to Genomics (with Katherine S. Pollard and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The Bioconductor R package multtest implements widely applicable resampling-based single-step and stepwise multiple testing procedures...
 

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Multiple Testing Procedures: R multtest Package and Applications to Genomics (with Katherine S. Pollard and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The Bioconductor R package multtest implements widely applicable resampling-based single-step and stepwise multiple testing procedures...
 

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Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Nicholas P. Jewell and Stephen Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Optimal designs of dose levels in order to estimate parameters from a model for binary...
 

Choice of Monitoring Mechanism for Optimal Nonparametric Functional Estimation for Binary Data (with Nicholas P. Jewell and Stephen Shiboski), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Optimal designs of dose levels in order to estimate parameters from a model for binary...
 

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Deletion/Substitution/Addition Algorithm for Partitioning the Covariate Space in Prediction (with Annette Molinaro), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a new method for predicting censored (and non-censored) clinical outcomes from a highly-complex...
 

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Multiple Testing and Data Adaptive Regression: An Application to HIV-1 Sequence Data (with Merrill D. Birkner and Sandra E. Sinisi), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological...
 

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Data Adaptive Estimation of the Treatment Specific Mean (with Yue Wang and Oliver Bembom), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
An important problem in epidemiology and medical research is the estimation of the causal effect...
 

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History-Adjusted Marginal Structural Models and Statically-Optimal Dynamic Treatment Regimes (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Marginal structural models (MSM) provide a powerful tool for estimating the causal effect of a...
 

PDF

Estimating a Survival Distribution with Current Status Data and High-Dimensional Covariates (with Aad van der Vaart), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We consider the inverse problem of estimating a survival distribution when the survival times are...
 

Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Alan E. Hubbard and Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
 

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Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome (with Alan E. Hubbard and Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
We propose a class of estimators of the treatment effect on a dichotomous outcome among...
 

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Estimation of Direct and Indirect Causal Effects in Longitudinal Studies (with Maya L. Petersen), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The causal effect of a treatment on an outcome is generally mediated by several intermediate...
 

Multiple Testing Methods For ChIP-Chip High Density Oligonucleotide Array Data (with Sunduz Keles, Sandrine Dudoit, and Simon E. Cawley), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Cawley et al. (2004) have recently mapped the locations of binding sites for three transcription...
 

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Multiple Testing Methods For ChIP-Chip High Density Oligonucleotide Array Data (with Sunduz Keles, Sandrine Dudoit, and Simon E. Cawley), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Cawley et al. (2004) have recently mapped the locations of binding sites for three transcription...
 

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Regulatory Motif Finding by Logic Regression (with Sunduz Keles and Chris Vulpe), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)

Multiple transcription factors coordinately control transcriptional regulation of genes in eukaryotes. Although multiple computational methods...

 

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A Statistical Method for Constructing Transcriptional Regulatory Networks Using Gene Expression and Sequence Data (with Biao Xing), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Transcriptional regulation is one of the most important means of gene regulation. Uncovering transcriptional regulatory...
 

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Loss-Based Cross-Validated Deletion/Substitution/Addition Algorithms in Estimation (with Sandra E. Sinisi), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
In van der Laan and Dudoit (2003) we propose and theoretically study a unified loss...
 

The Cross-Validated Adaptive Epsilon-Net Estimator (with Sandrine Dudoit and Aad W. van der Vaart), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Suppose that we observe a sample of independent and identically distributed realizations of a random...
 

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The Cross-Validated Adaptive Epsilon-Net Estimator (with Sandrine Dudoit and Aad W. van der Vaart), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
Suppose that we observe a sample of independent and identically distributed realizations of a random...
 

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Multiple Testing. Part III. Procedures for Control of the Generalized Family-Wise Error Rate and Proportion of False Positives (with Sandrine Dudoit and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The accompanying articles by Dudoit et al. (2003b) and van der Laan et al. (2003)...
 

Multiple Testing. Part III. Procedures for Control of the Generalized Family-Wise Error Rate and Proportion of False Positives (with Sandrine Dudoit and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2004)
The accompanying articles by Dudoit et al. (2003b) and van der Laan et al. (2003)...
 

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Comparison of the Inverse Probability of Treatment Weighted (IPTW) Estimator With a Naïve Estimator in the Analysis of Longitudinal Data With Time-Dependent Confounding: A Simulation Study (with Thaddeus Haight, Romain Neugebauer, and Ira B. Tager), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
A simulation study was conducted to compare estimates from a naïve estimator, using standard conditional...
 

Multiple Testing. Part II. Step-Down Procedures for Control of the Family-Wise Error Rate (with Sandrine Dudoit and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
The present article proposes two step-down multiple testing procedures for asymptotic control of the family-wise...
 

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Multiple Testing. Part II. Step-Down Procedures for Control of the Family-Wise Error Rate (with Sandrine Dudoit and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
The present article proposes two step-down multiple testing procedures for asymptotic control of the family-wise...
 

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Multiple Testing. Part I. Single-Step Procedures for Control of General Type I Error Rates (with Sandrine Dudoit and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
The present article proposes general single-step multiple testing procedures for controlling Type I error rates...
 

Multiple Testing. Part I. Single-Step Procedures for Control of General Type I Error Rates (with Sandrine Dudoit and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
The present article proposes general single-step multiple testing procedures for controlling Type I error rates...
 

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Loss-Based Estimation with Cross-Validation: Applications to Microarray Data Analysis and Motif Finding (with Sandrine Dudoit, Sunduz Keles, Annette M. Molinaro, Sandra E. Sinisi, and Siew Leng Teng), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Current statistical inference problems in genomic data analysis involve parameter estimation for high-dimensional multivariate distributions,...
 

Loss-Based Estimation with Cross-Validation: Applications to Microarray Data Analysis and Motif Finding (with Sandrine Dudoit, Sunduz Keles, Annette M. Molinaro, Sandra E. Sinisi, and Siew Leng Teng), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Current statistical inference problems in genomic data analysis involve parameter estimation for high-dimensional multivariate distributions,...
 

Unified Cross-Validation Methodology For Selection Among Estimators and a General Cross-Validated Adaptive Epsilon-Net Estimator: Finite Sample Oracle Inequalities and Examples (with Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)

In Part I of this article we propose a general cross-validation criterian for selecting among...

 

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Unified Cross-Validation Methodology For Selection Among Estimators and a General Cross-Validated Adaptive Epsilon-Net Estimator: Finite Sample Oracle Inequalities and Examples (with Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)

In Part I of this article we propose a general cross-validation criterian for selecting among...

 

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Measuring Treatment Effects Using Semiparametric Models (with Zhuo Yu), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
In order to estimate the causal effect of treatments on an outcome of interest, one...
 

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Asymptotically Optimal Model Selection Method with Right Censored Outcomes (with Sunduz Keles and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Over the last two decades, non-parametric and semi-parametric approaches that adapt well known techniques such...
 

Asymptotically Optimal Model Selection Method with Right Censored Outcomes (with Sunduz Keles and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Over the last two decades, non-parametric and semi-parametric approaches that adapt well known techniques such...
 

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Tree-based Multivariate Regression and Density Estimation with Right-Censored Data (with Annette M. Molinaro and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)

We propose a unified strategy for estimator construction, selection, and performance assessment in the presence...

 

Tree-based Multivariate Regression and Density Estimation with Right-Censored Data (with Annette M. Molinaro and Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)

We propose a unified strategy for estimator construction, selection, and performance assessment in the presence...

 

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Locally Efficient Estimation of Nonparametric Causal Effects on Mean Outcomes in Longitudinal Studies (with Romain Neugebauer), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Marginal Structural Models (MSM) have been introduced by Robins (1998a) as a powerful tool for...
 

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Resampling-based Multiple Testing: Asymptotic Control of Type I Error and Applications to Gene Expression Data (with Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
We define a general statistical framework for multiple hypothesis testing and show that the correct...
 

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Double Robust Estimation in Longitudinal Marginal Structural Models (with Zhuo Yu), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Consider estimation of causal parameters in a marginal structural model for the discrete intensity of...
 

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Supervised Detection of Regulatory Motifs in DNA Sequences (with Sunduz Keles, Sandrine Dudoit, Biao Xing, and Michael B. Eisen), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Identification of transcription factor binding sites (regulatory motifs) is a major interest in contemporary...
 

Supervised Detection of Regulatory Motifs in DNA Sequences (with Sunduz Keles, Sandrine Dudoit, Biao Xing, and Michael B. Eisen), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Identification of transcription factor binding sites (regulatory motifs) is a major interest in contemporary...
 

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A Semiparametric Model Selection Criterion with Applications to the Marginal Structural Model (with M. Alan Brookhart), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Estimators for the parameter of interest in semiparametric models often depend on a guessed model...
 

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Asymptotic Optimality of Likelihood Based Cross-Validation (with Sandrine Dudoit and Sunduz Keles), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Likelihood-based cross-validation is a statistical tool for selecting a density estimate based on n i.i.d....
 

Asymptotic Optimality of Likelihood Based Cross-Validation (with Sandrine Dudoit and Sunduz Keles), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Likelihood-based cross-validation is a statistical tool for selecting a density estimate based on n i.i.d....
 

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Asymptotics of Cross-Validated Risk Estimation in Estimator Selection and Performance Assessment (with Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Risk estimation is an important statistical question for the purposes of selecting a good estimator...
 

Asymptotics of Cross-Validated Risk Estimation in Estimator Selection and Performance Assessment (with Sandrine Dudoit), U.C. Berkeley Division of Biostatistics Working Paper Series (2003)
Risk estimation is an important statistical question for the purposes of selecting a good estimator...
 

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Recurrent Events Analysis in the Presence of Time Dependent Covariates and Dependent Censoring (with Maja Miloslavsky, Sunduz Keles, and Steve Butler), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Recurrent events models have lately received a lot of attention in the literature. The majority...
 

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Construction of Counterfactuals and the G-computation Formula (with Zhuo Yu), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Robins' causal inference theory assumes existence of treatment specific counterfactual variables so that the observed...
 

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Analysis of Longitudinal Marginal Structural Models (with Jennifer F. Bryan and Zhuo Yu), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In this article we construct and study estimators of the causal effect of a time-dependent...
 

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Locally Efficient Estimation with Bivariate Right Censored Data (with Christopher M. Quale and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Estimation for bivariate right censored data is a problem that has had much study over...
 

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An Empirical Study of Marginal Structural Models for Time-Independent Treatment (with Tanya A. Henneman), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In non-randomized treatment studies a significant problem for statisticians is determining how best to adjust...
 

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Locally Efficient Estimation of Regression Parameters Using Current Status Data (with Chris Andrews and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

In biostatistics applications interest often focuses on the estimation of the distribution of a time-variable...

 

Case-Control Current Status Data (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Current status observation on survival times has recently been widely studied. An extreme form of...
 

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Case-Control Current Status Data (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Current status observation on survival times has recently been widely studied. An extreme form of...
 

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Why Prefer Double Robust Estimates? Illustration with Causal Point Treatment Studies (with Romain Neugebauer), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In point treatment marginal structural models with treatment A, outcome Y and covariates W, causal...
 

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Bivariate Current Status Data (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In many applications, it is often of interest to estimate a bivariate distribution of two...
 

Bivariate Current Status Data (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
In many applications, it is often of interest to estimate a bivariate distribution of two...
 

Current Status Data: Review, Recent Developments and Open Problems (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Researchers working with survival data are by now adept at handling issues associated with incomplete...
 

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Current Status Data: Review, Recent Developments and Open Problems (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Researchers working with survival data are by now adept at handling issues associated with incomplete...
 

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Estimation of the Bivariate Survival Function with Generalized Bivariate Right Censored Data Structures (with Sunduz Keles and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
We propose a bivariate survival function estimator for a general right censored data structure that...
 

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A Method to Identify Significant Clusters in Gene Expression Data (with Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Clustering algorithms have been widely applied to gene expression data. For both hierarchical and partitioning...
 

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Comparative Genomic Hybridization Array Analysis (with Annette M. Molinaro and Dan H. Moore), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)

At the present time, there is increasing evidence that cancer may be regulated by the...

 

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A New Partitioning Around Medoids Algorithm (with Katherine S. Pollard and Jennifer Bryan), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
Kaufman & Rousseeuw (1990) proposed a clustering algorithm Partitioning Around Medoids (PAM) which maps a...
 

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Estimating Causal Parameters in Marginal Structural Models with Unmeasured Confounders Using Instrumental Variables (with Tanya A. Henneman and Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (2002)
For statisticians analyzing medical data, a significant problem in determining the causal effect of a...
 

Locally Efficient Estimation with Bivariate Right Censored Data (with Christopher M. Quale and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
Estimation for bivariate right censored data is a problem that has had much study over...
 

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Identification of Regulatory Elements Using A Feature Selection Method (with Sunduz Keles and Michael B. Eisen), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
Many methods have been described to identify regulatory motifs in the transcription control regions of...
 

Nonparametric Estimation from Current Status Data with Competing Risks (with Nicholas P. Jewell and Tanya Henneman), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
A great deal of recent attention has focused on the estimation of survival distributions based...
 

Nonparametric Estimation from Current Status Data with Competing Risks (with Nicholas P. Jewell and Tanya Henneman), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
A great deal of recent attention has focused on the estimation of survival distributions based...
 

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Statistical Inference for Simultaneous Clustering of Gene Expression Data (with Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
Current methods for analysis of gene expression data are mostly based on clustering and classification...
 

Paired and Unpaired Comparisons and Clustering with Gene Expression Data (with Jennifer F. Bryan and Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
We have previously described a statistical framework for using gene expression data from cDNA microarrays...
 

Hybrid Clustering of Gene Expression Data with Visualization and the Bootstrap (with Katherine S. Pollard), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
Large-scale gene expression studies are coming increasingly common as new technologies make it possible to...
 

Current Status and Right-Censored Data Structures When Observing a Marker at the Censoring Time (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)

We study nonparametric estimation with two types of data structures. In the first data structure...

 

Current Status and Right-Censored Data Structures When Observing a Marker at the Censoring Time (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)

We study nonparametric estimation with two types of data structures. In the first data structure...

 

Smooth Estimation of a Monotone Density (with Aad W. van der Vaart), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
We investigate the interplay of smoothness and monotonicity assumptions when estimating a density from a...
 

Fitting of Mixtures with Unspecified Number of Components Using Cross Validation Distance Estimate (with Maja Miloslavsky), U.C. Berkeley Division of Biostatistics Working Paper Series (2001)
Estimation of the number of mixture components (k) is an unsolved problem. Available methods for...
 

Gene Expression Analysis with the Parametric Bootstrap (with Jennifer F. Bryan), U.C. Berkeley Division of Biostatistics Working Paper Series (2000)
Recent developments in microarray technology make it possible to capture the gene expression profiles for...
 

Locally Efficient Estimation in Censored Data Models: Theory and Examples (with Richard D. Gill and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (2000)
In many applications the observed data can be viewed as a censored high dimensional full...
 

Locally Efficient Estimation of a Multivariate Survival Function in Longitudinal Studies (with Alan E. Hubbard and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (2000)
In this paper we develop a locally efficient one-step estimator of a multivariate survival function...
 

The NPMLE in the Uniform Doubly Censored Current Status Data Model (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1999)
In biostatistical applications interest often focuses on the estimation of the distribution of time T...
 

The NPMLE in the Uniform Doubly Censored Current Status Data Model (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1999)
In biostatistical applications interest often focuses on the estimation of the distribution of time T...
 

Nonparametric Efficient Estimation with Current Status Data and Right-Censored Data Structures When Observing a Marker at the Censoring Time (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)
We study nonparametric estimation with two types of data structures. In the first data structure...
 

Nonparametric Efficient Estimation with Current Status Data and Right-Censored Data Structures When Observing a Marker at the Censoring Time (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)
We study nonparametric estimation with two types of data structures. In the first data structure...
 

Estimation with Interval Censored Data in Longitudinal Studies, U.C. Berkeley Division of Biostatistics Working Paper Series (1998)

In biostatistical applications interest often focuses on the estimation of the distribution of a time-until-event...

 

The Nonparametric Maximum Likelihood Estimator in a Class of Doubly Censored Current Status Data Models with Application to Partner Studies (with Chris Andrews), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)
The California Partners' Study is an ongoing investigation of heterosexual HIV transmission in partners of...
 

Subset Selection Based on Order Statistics from Logistic Populations (with Paul van der Laan), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)

Consider k equal size treatment groups and let the outcome of interest be a survival...

 

Inference with Bivariate Truncated Data (with Christopher M. Quale), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)
In this paper we build on previous work for estimation of the bivariate distribution of...
 

Locally Efficient Estimation of the Quality Adjusted Lifetime Distribution with Right-Censored Data and Covariates (with Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)
Zhao and Tsiatis (1997) consider the problem of estimation of the distribution of the quality...
 

Nonparametric Locally Efficient Estimation of the Treatment Specific Survival Distribution with Right Censored Data and Covariates in Observational Studies (with Alan E. Hubbard and James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (1998)

In many observational studies one is concerned with comparing treatment specific survival distributions in the...

 

Efficient Estimation from Right-Censored Data When Failure Indicators are Missing at Random (with Ian W. McKeague), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)
The Kaplan-Meier estimator of a survival function is well known to be asymp- totically efficient...
 

Efficient Estimation from Right-Censored Data When Failure Indicators are Missing at Random (with Ian W. McKeague), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)
The Kaplan-Meier estimator of a survival function is well known to be asymp- totically efficient...
 

Efficient Estimation of the Lifetime and Disease Onset Distribution (with Nicholas P. Jewell and Derick R. Peterson), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)
We study efficient nonparametric maximum likelihood estimation of the distribution of onset and lifetime associated...
 

Efficient Estimation of the Lifetime and Disease Onset Distribution (with Nicholas P. Jewell and Derick R. Peterson), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)
We study efficient nonparametric maximum likelihood estimation of the distribution of onset and lifetime associated...
 

Smooth Estimation and Inference with Interval Censored Data (with Derick R. Peterson), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)
In many biostatistical applications one is concerned with estimating the distribution of a survival time...
 

Locally Efficient Estimation of the Survival Distribution with Right Censored Data and Covariates When Collection of Data is Delayed (with Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)

For many sources of survival data, there is a delay between the recording of vital...

 

Locally Efficient Estimation with Current Status Data and Time-Dependent Covariates (with James M. Robins), U.C. Berkeley Division of Biostatistics Working Paper Series (1997)

In biostatistical applications interest often focuses on the estimation of the distribution of a failure...

 

Estimation with Interval Censored Data and Covariates (with Alan E. Hubbard), U.C. Berkeley Division of Biostatistics Working Paper Series (1996)
In biostatistical applications interest often focuses on the estimation of the distribution of time T...
 

Singly and Doubly Censored Current Status Data With Extensions to Multi-State Counting Processes (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1996)

In estimation of a survival function, current status data arises when the only information available...

 

Singly and Doubly Censored Current Status Data With Extensions to Multi-State Counting Processes (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1996)

In estimation of a survival function, current status data arises when the only information available...

 

Locally Efficient Estimation with Current Status Data and High Dimensional Covariates, U.C. Berkeley Division of Biostatistics Working Paper Series (1995)

In biostatistical applications, interest often focuses on the estimation of the distribution of time T...

 

The Two-Interval Line-Segment Problem, U.C. Berkeley Division of Biostatistics Working Paper Series (1995)
In this paper, the NPMLE in the one-dimensional line segment problem is defined and studied,...
 

Efficiency of the Sieved-NPMLE in CAR-Missing Data Models, U.C. Berkeley Division of Biostatistics Working Paper Series (1995)

We consider nonparametric missing data models for which the censoring mechanism satisfies coarsening at random...

 

Nonparametric Estimation of the Bivariate Survival Function with Truncated Data, U.C. Berkeley Division of Biostatistics Working Paper Series (1995)
Randomly left or right truncated observations occur when one is concerned with estimation of the...
 

Singly and Doubly Censored Current Status Data: Estimation, Asymptotics and Regression (with Peter J. Bickel and Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

In biostatistical applications interest is often focused on the estimation of the distribution of time...

 

Singly and Doubly Censored Current Status Data: Estimation, Asymptotics and Regression (with Peter J. Bickel and Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

In biostatistical applications interest is often focused on the estimation of the distribution of time...

 

Efficient and Ad Hoc Estimation in the Bivariate Censoring Model, U.C. Berkeley Division of Biostatistics Working Paper Series (1994)
A large number of proposals for estimating the bivariate survival function under random censoring has...
 

Generalizations of Current Status Data With Applications (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)
In estimation of a survival function, current status data arises when the only information available...
 

Generalizations of Current Status Data With Applications (with Nicholas P. Jewell), U.C. Berkeley Division of Biostatistics Working Paper Series (1994)
In estimation of a survival function, current status data arises when the only information available...
 

Proving Efficiency of NPMLE and Identities, U.C. Berkeley Division of Biostatistics Working Paper Series (1994)

A method is given for proving efficiency of NPMLE directly linked to empirical process theory....