Dr. Mark Jareb's research examines fundamental questions regarding the cell
biology and development of neurons. His lab uses primary cultures of embryonic chick
forebrain neurons as a model system to study the development and maintenance of neuronal
polarity. Neurons are polarized in that they have morphologically distinct processes
called axons and dendrites which have specific functions. Typically, the cell body and
dendrites function to receive information while the axon transmits information. A central
mechanism underlying this functional polarity is the sorting and trafficking of membrane
proteins to either the axon or dendrities. His work focuses on how proteins that make the
axon functionally unique are trafficked to the correct location. 

Articles

Link

Mapping of Presynaptic Nicotinic Acetylcholine Receptors Using Fluorescence Imaging of Neuritic Calcium (with Romain Girod, Jason Moss, and Lorna Role), Biology Faculty Publications (2003)

Neuronal nicotinic receptors (nAChRs) appear to function at both pre- and postsynaptic sites, to modulate...

 

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The Polarized Sorting of Membrane Proteins Expressed in Cultured Hippocampal Neurons Using Viral Vectors (with Gary Banker), Biology Faculty Publications (1998)

One model of neuronal polarity (Dotti and Simons, 1990) proposes that neurons and polarized epithelia...

 

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Inhibition of Axonal Growth by Brefeldin A in Hippocampal Neurons in Culture (with Gary Banker), Biology Faculty Publications (1997)

The outgrowth of neuronal processes involves a great increase in the surface area of the...