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Selected Works of Mark R. Ackermann
Article
Protection of Pasteurella multocida dermonecrotic toxin-challenged rats by toxoid-induced antibody
Veterinary Microbiology (1993)
  • R. K. Pettit, United States Department of Agriculture
  • R. B. Rimler, United States Department of Agriculture
  • Mark R. Ackermann, United States Department of Agriculture
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Abstract

Two different doses of glutaraldehyde-treated Pasteurella multocida dermonecrotic toxin (PMDT) were used to immunize rats. Rats developed serum IgG antibodies specific for native PMDT, and IgG titers increased with dose and number of toxoid immunizations. Survival rates in both active immunization and passive serum neutralization experiments were dependent on dose of toxoid vaccination and serum levels of anti-PMDT IgG. Vaccination with toxoid prevented weight loss but not leukocytosis and increased complement titers in toxin-challenged rats. Toxoid, itself, induced minimal leukocytosis but no alterations in complement titers or weight gain.

Disciplines
Publication Date
February, 1993
Publisher Statement
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Citation Information
R. K. Pettit, R. B. Rimler and Mark R. Ackermann. "Protection of Pasteurella multocida dermonecrotic toxin-challenged rats by toxoid-induced antibody" Veterinary Microbiology Vol. 34 Iss. 2 (1993)
Available at: http://works.bepress.com/mark_ackermann/66/