Articles
Molecular imaging of cyclooxygenase-2 in canine transitional cell carcinomas in vitro and in vivo (with M J. Uddin, Joseph W. Bartges, Amanda Callens, Kusum Rathore, Alfred Legendre, L Wright, and L J. Marnett), Cancer Prevention Research (2013)
The enzyme COX-2 is induced at high levels in tumors but not in surrounding normal...
Modulation of adipose tissue inflammation by bioactive food compounds (with N. S. Kalupahana; M. Lemieux; B. Greer; and N, Moustaid-Moussa), Journal of Nutritional Biochemistry (2013)
Adipose tissue has an important endocrine function in the regulation of whole-body metabolism. Obesity leads...
Neutron radiography with combined computed tomography: a novel tool for cancer diagnosis and imaging (Abstract) (with H Z. Bilheux, Kusum Rathore, J C. Bilheux, L Walker, Robert L. Donnell, and Alfred Legendre), AACR/SNMMI Conference on State-of-the-Art Molecular Imaging in Cancer Biology and Therapy (2013)
Preclinical single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model (with M J. Uddin, Alfred Legendre, Gina Gaylon, Joseph Bartges, Amanda Callens, and L Marnett), Journal of Biomedical Optics (2012)
We evaluated preclinical single-dose safety, pharmacokinetic properties, and specific uptake of the new optical imaging...
MCC-555-induced NAG-1 expression is mediated in part by KLF4. (with Seong-Ho Lee, Michael McEntee, and Seung J. Baek), Eur J Pharmacol (2010)
Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a central role in cell differentiation, metabolism and tumorigenesis....
PPAR agonists down-regulate the expression of Atp10c mRNA during adipogenesis (with A Peretich, S Hurst, SJ Baek, and Madhu Dahr), Open Obesity Journal (2009)
Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice (with Seong-Ho Lee, Robert L. Donnell, M Sukhthankar, TE Eling, SM Fischer, and Seung J. Baek), Cancer prevention research (2009)
The expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) inhibits gastrointestinal tumorigenesis in NAG-1 transgenic mice...
A novel peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways (with K Yamaguchi, Michael F. McEntee, J H. Yoon, S M. Fischer, I B. Renes, I Van Seungnigen, and Seung J. Baek), Molecular Cancer Therapeutics (2008)
A large body of studies has suggested that peroxisome proliferator-activated receptor gamma (PPARgamma) ligands, such...
Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells (with J Yuan, X Li, K B. Kim, and Seung J. Baek), International Journal of Oncology (2008)
The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear transcription factor that controls the genes...
Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells (with Seong Ho Lee and Seung J. Baek), Molecular Carcinogensis (2008)
6-Gingerol, a natural product of ginger, has been known to possess anti-tumorigenic and pro-apoptotic activities....
Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1 (with R Fernando, JS Foster, A Bible, A Ström, RG Pestell, M Rao, Arnold Saxton, Seung J. Baek, K Yamaguchi, Robert R. Donnell, and J Wimalasena), The Journal of biological chemistry (2007)
Recent investigations suggest that functions of the proapoptotic BCL2 family members, including BAD, are not...
Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma (with M Majidi, T Masi, Hussein Al-Wadei, and Hildegard Schuller), Cancer (2007)
BACKGROUND: Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and has a high...
NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells (with E Laag, M Majidi, T Masi, T Takahashi, and Hildegard Schuller), International journal of cancer (2006)
We have shown that the tobacco nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an agonist for -adrenergic receptors...
Pulmonary fibroblasts stimulate the proliferation of cell lines from human lung adenocarcinomas (with T Masi, Howard Plummer 3rd, M Majidi, P Fedorocko, and Hildegard Schuller), Anti-cancer drugs (2006)
Human lung cancer cell lines are widely used to test anticancer drugs. These in-vitro tests,...
Detection of overexpressed COX-2 in precancerous lesions of hamster pancreas and lungs by molecular imaging: implications for early diagnosis and prevention (with Hildegard Schuller, George Kabalka, G Smith, A Mereddy, and M Akula), ChemMedChem (2006)
The enzyme cyclooxygenase-2 (COX-2) is overexpressed in many cancers, cardiovascular disease, neurodegenerative disorders, and arthritis....
Synergistic mitogenic signaling of the tobacco specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and ethanol on immortalized human pancreatic duct epithelial cells (with MDF Askari, MS Tsao, and Hildegard Schuller), Pancreas (2006)
Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms (with T Masi, K Walker, H Bernart, M Majidi, JM Becker, and Hildegard Schuller), Genes, chromosomes & cancer (2005)
Cigarette smoking contributes to the development of lung cancer throughout the world, with cases of...
Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines (with Howard Plummer 3rd, Madhu Dhar, and Hildegard Schuller), BMC cancer (2005)
BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between...
NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways (with Hildegard Schuller), Lung cancer (2005)
Pulmonary adenocarcinoma (PAC) is the most common type of human lung cancer. A diagnosis of...
Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease (with A Bukovsky, K Indrapichate, H Fujiwara, ME Ayala, R Dominguez, MR Caudle, J Wimalsena, RF Elder, P Copas, JF Foster, RI Fernando, DC Henley, and NB Upadhyaya), Reproductive biology and endocrinology : RB&E (2003)
Distinct luteinizing hormone receptor (LHR) protein variants exist due to the posttranslational modifications. Besides ovaries,...
Placental expression of estrogen receptor beta and its hormone binding variant--comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells. (with A Bukovsky, M R. Caudle, R I. Fernando, J Wimalasena, J S. Foster, D C. Henley, and R F. Elder), Reproductive biology and endocrinology (2003)
During human pregnancy, the production of 17-beta-estradiol (E2) rises steadily to eighty fold at term,...
Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol (with A Bukovsky, MR Caudle, J Wimalasena, JS Foster, DC Henley, and RF Elder), Reproductive biology and endocrinology : RB&E (2003)
Estrogens play an important role in the regulation of placental function, and 17-beta-estradiol (E2) production...
Placental expression of estrogen receptor beta and its hormone binding variant – comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells (with Antonin Bukovsky, Michael R. Caudle, Romaine I. Fernando, Jay Wimalasena, James S. Foster, Donald C. Henley, and Robert F. Elder), Reproductive Biology and Endocrinology (2003)
During human pregnancy, the production of 17-beta-estradiol (E2) rises steadily to eighty fold at term,...
Variability of placental expression of cyclin E low molecular weight variants (with A Bukovsky, MR Caudle, J Wimalasena, JS Foster, JA Keenan, and RF Elder), Biology of reproduction (2002)
Cyclin E, a G(1) cyclin serving to activate cyclin-dependent kinase 2, is the only cyclin...
Effect of acetazolamide on hypericin photocytotoxicity (with P Solar, I Cavarga, J Hofmanova, P Miskovsky, P Brezani, G Hrckova, A Kozubik, and P Fedorocko), Planta medica (2002)
The photodynamic action of hypericin (HYP) in vitro was evaluated using human leukemic HL-60 and...
Variability of placental expression of cyclin E low molecular weight variants (with A Bukovsky, MR Caudle, J Wimalasena, JS Foster, JA Keenan, and RF Elder), Biol. Reprod (2002)
Photodynamic therapy of murine fibrosarcoma with topical and systemic administration of hypericin (with I Cavarga, P Brezani, P Solar, P Fedorocko, and P Miskovsky), Phytomedicine : international journal of phytotherapy and phytopharmacology (2001)
The in vivo antitumour activity of the natural photosensitizer hypericin was evaluated. C3H/DiSn mice inoculated...
Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders - a relationship to the cellular differentiation and degeneration. (with A Bukovsky, P Copas, M R. Caudle, T Dassanayake, B Asbury, S E. VanMeter, R F. Elder, J B. Brown, and S B. Cross), BMC clinical pathology (2001)
BACKGROUND: Pelvic floor disorders affect almost 50% of aging women. An important role in the...
Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders – a relationship to the cellular differentiation and degeneration (with Antonin Bukovsky, Pleas Copas, Michael R. Caudle, Tamara Dassanayake, Bridgett Asbury, Stuart E. Van Meter, Robert F. Elder, Jeffrey B. Brown, and Stephanie B. Cross), BMC Clinical Pathology (2001)
Background Pelvic floor disorders affect almost 50% of aging women. An important role in the...