As a new generation of African leaders is emerging, so is the need to create appropriate and effective leadership paradigms for personal and organizational development. Servant leadership and cultural intelligence are essential pillars for identifying, developing and sustaining value-based leadership practices. Drawing from the Service Leadership model that emerged from the Depaul Leadership Project (DLP); this article outlines the competencies, orientations, methods and strategies for establishing effective and culturally intelligent sustainable leadership development programs. The Depaul leadership development model proposes that a collaborative, value-centered, and service-oriented perspective be at the center of an effective and sustainable African leadership development program. This innovative and cross-cultural leadership development model bridges theories and best practices from the sustainable development, service leadership and cultural intelligence paradigms in leadership and organizational development. National or international institutions committed to effective organizational and leadership development can adopt and adapt this African sustainable leadership development model to fit their needs.