Amyotrophic Lateral Sclerosis

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Titanium

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

Multiple Sclerosis

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

Perceptual Disorders

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Oxygen

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Dipyridamole

Therapeutics

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Cardiovascular Diseases

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 

Cerebral Hemorrhage

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

*Behavior, Animal

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

*Models, Statistical

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

Potassium Chloride

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 

Prognosis

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Ischemic cerebral vascular disease: an overview, Arquivos de neuro-psiquiatria (1991)

The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Platelet Glycoprotein GPIIb-IIIa Complex

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

*Magnetic Resonance Imaging

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 

Regional Blood Flow

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

Indoles

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Streptokinase

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 

Transient

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

*Magnetic Resonance Angiography

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Injections, Intravenous

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Brain Ischemia

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

PDF

Animal models of focal brain ischemia (with Kenneth M. Sicard), Experimental and translational stroke medicine (2010)

Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Implications of Stroke Pathophysiology and the Ischemic Penumbra (with Rajat Kumar), Neurology Publications and Presentations (2009)

Published in: Bornstein NM (editor), Stroke: Practical Implications for Clinicians, Basel: Karger, 2009, p.24-36. ISBN...

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
The ischemic penumbra: identification, evolution and treatment concepts, Cerebrovascular diseases (Basel, Switzerland) (2003)

The concept of the ischemic penumbra is an important one for both basic investigators of...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment, Neurology Publications and Presentations (2003)

No abstract provided.

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Stroke Therapy (2nd ed.), Neurology Publications and Presentations (2001)

This second edition covers developments in the field regarding effective therapy for cerebrovascular disorders. It...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Prevention of Ischemic Stroke (with Cesare Fieschi), Neurology Publications and Presentations (2000)

No abstract provided.

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (with Gregory W. Albers), Neurology (1999)

Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 
Medical therapy for ischemic stroke (with Brian Silver and Johannes Weber), Clinical neuropharmacology (1996)

Therapy for stroke is undergoing major changes. Many of the changes parallel the advances made...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 

Magnetic Resonance Angiography

Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Neurology Publications and Presentations (2003)

No abstract provided.

 

Severity of Illness Index

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

National Institutes of Health (U.S.)

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Decision Making

Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 

Humans

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Link

Introduction to advances in stroke 2009, Stroke; a journal of cerebral circulation (2010)
 

Link

Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 

PDF

Advances in Stroke 2007: introduction, Stroke; a journal of cerebral circulation (2008)
 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

File

Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

PDF

The MATCH study results in the context of secondary stroke prevention (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
The ischemic penumbra: identification, evolution and treatment concepts, Cerebrovascular diseases (Basel, Switzerland) (2003)

The concept of the ischemic penumbra is an important one for both basic investigators of...

 

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Patients with acute stroke: recent developments in neuroimaging (with Pierre C. Combremont), Current atherosclerosis reports (2000)

The authors discuss recent developments in neuroimaging and their role in the evaluation of patients...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Pharmacological approaches to stroke recovery (with Seth P. Finklestein), Cerebrovascular diseases (Basel, Switzerland) (1999)
 
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (with Gregory W. Albers), Neurology (1999)

Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 
Medical therapy for ischemic stroke (with Brian Silver and Johannes Weber), Clinical neuropharmacology (1996)

Therapy for stroke is undergoing major changes. Many of the changes parallel the advances made...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Acute stroke treatment trials in the United States. Rethinking strategies for success (with Robert J. Adams, Anthony J. Furlan, and Gregory del Zoppo), Stroke; a journal of cerebral circulation (1995)

In this editorial, we present some of the important issues facing those who design and...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 
Ischemic cerebral vascular disease: an overview, Arquivos de neuro-psiquiatria (1991)

The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
Atherosclerosis: cellular aspects and potential interventions, Cerebrovascular and brain metabolism reviews (1991)

The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 
n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 
The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 
The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 
Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 
Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 
Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

Perfusion

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 

Oxygen Inhalation Therapy

Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

Double-Blind Method

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Recombinant Proteins

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 

Multivariate Analysis

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Disease Progression

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

Ischemic Attack, Transient

PDF

Cortical Vein Thrombosis as a Mimic for Isolated Cortical Subarachnoid Hemorrhage and Transient Ischemic Attack (with Jane G. Morris and Raphael A. Carandang), Case reports in neurology (2010)

Isolated cortical subarachnoid hemorrhage is rare and poorly understood. Differential diagnoses and proposed pathophysiology vary...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 
Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 

Brain Damage, Chronic

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Cerebrovascular Disorders

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Imaging as a Surrogate Marker in Clinical Trials, Neurology Publications and Presentations (2003)

No abstract provided.

 
Neurovascular Disorders (with E. Orberk and M. Ramzan), Neurology Publications and Presentations (2003)

No abstract provided.

 
Current Review of Cerebrovascular Disease (4th ed.) (with Julien Bogousslavsky), Neurology Publications and Presentations (2000)

Advances in the field of cerebrovascular medicine occur at a rapid pace. The fourth edition...

 
Pharmacological approaches to stroke recovery (with Seth P. Finklestein), Cerebrovascular diseases (Basel, Switzerland) (1999)
 
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (with Gregory W. Albers), Neurology (1999)

Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are...

 
Current Review of Cerebrovascular Disease (3rd ed.) (with Julien Bogousslavsky), Neurology Publications and Presentations (1999)

No abstract provided.

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 
Medical therapy for ischemic stroke (with Brian Silver and Johannes Weber), Clinical neuropharmacology (1996)

Therapy for stroke is undergoing major changes. Many of the changes parallel the advances made...

 
Current Review of Cerebrovascular Disease (2nd ed.) (with Julien Bogousslavsky), Neurology Publications and Presentations (1996)

No abstract provided.

 
Acute stroke treatment trials in the United States. Rethinking strategies for success (with Robert J. Adams, Anthony J. Furlan, and Gregory del Zoppo), Stroke; a journal of cerebral circulation (1995)

In this editorial, we present some of the important issues facing those who design and...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Stroke Therapy, Neurology Publications and Presentations (1995)

No abstract provided.

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 
Clinical Atlas of Cerebrovascular Disorders, Neurology Publications and Presentations (1994)

No abstract available.

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Current Review of Cerebrovascular Disease (with Julien Bogousslavsky), Neurology Publications and Presentations (1993)

No abstract provided.

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

Outcome Assessment (Health Care)

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

*Neuroprotective Agents

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Cardiac Surgical Procedures

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

*Diffusion Magnetic Resonance Imaging

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Odds Ratio

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Rats

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 

Microspheres

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

*Reperfusion

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 

Image Processing, Computer-Assisted

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 

Dimethyl Sulfoxide

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Ligation

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

Hypercapnia

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

*Disability Evaluation

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Clinical Trials as Topic

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Acute stroke treatment trials in the United States. Rethinking strategies for success (with Robert J. Adams, Anthony J. Furlan, and Gregory del Zoppo), Stroke; a journal of cerebral circulation (1995)

In this editorial, we present some of the important issues facing those who design and...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Ticlopidine

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

*Health Planning Guidelines

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 

Polyethylene

Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Self-Evaluation Programs

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Nervous System Diseases

Link

Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)

This reference work covers every major methodology and disease model used in current neuroscience research....

 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)

No abstract available.

 
Textbook of Neurology (with Julien Bogousslavsky), Neurology Publications and Presentations (1998)

No abstract provided.

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 

Heparin

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 

Brain

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
Medical therapy for ischemic stroke (with Brian Silver and Johannes Weber), Clinical neuropharmacology (1996)

Therapy for stroke is undergoing major changes. Many of the changes parallel the advances made...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 

Prospective Studies

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Activities of Daily Living

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Pharmacological approaches to stroke recovery (with Seth P. Finklestein), Cerebrovascular diseases (Basel, Switzerland) (1999)
 

*Clinical Trials as Topic

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 

PDF

The MATCH study results in the context of secondary stroke prevention (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Risk

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 

Drug Design

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

Behavior, Animal

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Endpoint Determination

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

Meta-Analysis as Topic

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Inflammation

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 

Artery

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

*Hyperoxia

Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

Reperfusion Injury

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 

Embolism

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 

Venous Thrombosis

PDF

Cortical Vein Thrombosis as a Mimic for Isolated Cortical Subarachnoid Hemorrhage and Transient Ischemic Attack (with Jane G. Morris and Raphael A. Carandang), Case reports in neurology (2010)

Isolated cortical subarachnoid hemorrhage is rare and poorly understood. Differential diagnoses and proposed pathophysiology vary...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Glycine Agents

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Brain Mapping

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 

Species Specificity

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

Blood Pressure

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Body Temperature

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Observer Variation

Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Reproducibility of Results

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 

Acute Disease

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 

Ganglia, Parasympathetic

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

Pilot Projects

Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Research Design

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 

Diffusion

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 

Time Factors

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 

Heparin, Low-Molecular-Weight

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 

Heptanoic Acids

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Cerebral Infarction

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 

United States

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 
Acute stroke treatment trials in the United States. Rethinking strategies for success (with Robert J. Adams, Anthony J. Furlan, and Gregory del Zoppo), Stroke; a journal of cerebral circulation (1995)

In this editorial, we present some of the important issues facing those who design and...

 

Tetrazolium Salts

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 

*Spreading Cortical Depression

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 

Models, Animal

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 

Coloring Agents

Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 

Male

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 
Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 
Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

*Treatment Outcome

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

Recurrence

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 

Drug Combinations

Aspirin

Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Infarction, Middle Cerebral Artery

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 

Pyrazines

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

*Randomized Controlled Trials as Topic

The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Parkinson Disease

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Regression Analysis

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Nerve Net

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Neurodegenerative Diseases

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Follow-Up Studies

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 

Water

Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 

Caspase 1

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Thrombolytic Therapy

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 

Silicon

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Vascular Surgical Procedures

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Nerve Fibers

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 

Drug Therapy, Combination

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 

Automation

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Alzheimer Disease

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Magnetic Resonance Imaging

Link

MRI of stroke using hyperpolarized (129)Xe (with Xin Zhou, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, and Mitchell Albert), NMR in biomedicine (2010)

Because there is no background signal from xenon in biological tissue, and because inhaled xenon...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Magnetic Resonance Imaging in Stroke (with Stephen Davis and Steven Warach), Neurology Publications and Presentations (2003)

Magnetic resonance imaging (MRI) provides non-invasive information about the brain's blood flow, water movement and...

 
Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Neurology Publications and Presentations (2003)

No abstract provided.

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (with Gregory W. Albers), Neurology (1999)

Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 

Aged, 80 and over

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 

Drug Administration Schedule

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Contrast Media

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Expert Testimony

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Psychomotor Performance

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Probability

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

Fibrinolytic Agents

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Virginia

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 

Stroke

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

MRI of stroke using hyperpolarized (129)Xe (with Xin Zhou, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, and Mitchell Albert), NMR in biomedicine (2010)

Because there is no background signal from xenon in biological tissue, and because inhaled xenon...

 

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Link

A New Era Begins, Stroke; a journal of cerebral circulation (2010)
 

PDF

Animal models of focal brain ischemia (with Kenneth M. Sicard), Experimental and translational stroke medicine (2010)

Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology...

 

Link

Introduction to advances in stroke 2009, Stroke; a journal of cerebral circulation (2010)
 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Handbook of Clinical Neurology Volume 92, Stroke Part I: Basic and Epidemiological Aspects, Neurology Publications and Presentations (2009)

The first of three volumes on stroke in the Handbook of Clinical Neurology covering historical...

 

Link

Handbook of Clinical Neurology Volume 93, Stroke Part II: Clinical Manifestations and Pathogenesis, Neurology Publications and Presentations (2009)

The second of three volumes on stroke in the Handbook of Clinical Neurology series covering...

 

Link

Handbook of Clinical Neurology Volume 94, Stroke Part III: Investigation and Management, Neurology Publications and Presentations (2009)

The third of three volumes on stroke in the Handbook of Clinical Neurology series covering...

 

Link

Implications of Stroke Pathophysiology and the Ischemic Penumbra (with Rajat Kumar), Neurology Publications and Presentations (2009)

Published in: Bornstein NM (editor), Stroke: Practical Implications for Clinicians, Basel: Karger, 2009, p.24-36. ISBN...

 

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 

PDF

Advances in Stroke 2007: introduction, Stroke; a journal of cerebral circulation (2008)
 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)

No abstract available.

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

File

Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

PDF

The MATCH study results in the context of secondary stroke prevention (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
The ischemic penumbra: identification, evolution and treatment concepts, Cerebrovascular diseases (Basel, Switzerland) (2003)

The concept of the ischemic penumbra is an important one for both basic investigators of...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 
Magnetic Resonance Imaging in Stroke (with Stephen Davis and Steven Warach), Neurology Publications and Presentations (2003)

Magnetic resonance imaging (MRI) provides non-invasive information about the brain's blood flow, water movement and...

 
Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Neurology Publications and Presentations (2003)

No abstract provided.

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
Combination Therapies, Restorative Therapies and Future Directions (with Majaz Moonis), Neurology Publications and Presentations (2003)

No abstract provided.

 
Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment, Neurology Publications and Presentations (2003)

No abstract provided.

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Stroke Therapy (2nd ed.), Neurology Publications and Presentations (2001)

This second edition covers developments in the field regarding effective therapy for cerebrovascular disorders. It...

 
Patients with acute stroke: recent developments in neuroimaging (with Pierre C. Combremont), Current atherosclerosis reports (2000)

The authors discuss recent developments in neuroimaging and their role in the evaluation of patients...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Prevention of Ischemic Stroke (with Cesare Fieschi), Neurology Publications and Presentations (2000)

No abstract provided.

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 
Stroke Therapy, Neurology Publications and Presentations (1995)

No abstract provided.

 

Simvastatin

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Diagnostic Imaging

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)

No abstract available.

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Imaging as a Surrogate Marker in Clinical Trials, Neurology Publications and Presentations (2003)

No abstract provided.

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Sensation Disorders

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

*Infarction, Middle Cerebral Artery

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

Movement Disorders

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Treatment Outcome

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 

Ischemic Attack,

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Platelet Aggregation Inhibitors

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

PDF

The MATCH study results in the context of secondary stroke prevention (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 

Primary Prevention

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

*Diagnostic Imaging

Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

Intracranial Aneurysm

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

Brain Infarction

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Carotid Artery, External

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

Sutures

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Surface Properties

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Algorithms

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 

Randomized Controlled Trials as Topic

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 

Female

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 
Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

Neurons

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 

Brain Edema

Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Proteasome Endopeptidase Complex

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Circle of Willis

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

*Algorithms

Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 

Survival Analysis

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 

Pyrroles

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Rats, Wistar

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Boronic Acids

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Animals

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
Atherosclerosis: cellular aspects and potential interventions, Cerebrovascular and brain metabolism reviews (1991)

The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 
Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 
The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Risk Assessment

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

Antihypertensive Agents

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Quality of Life

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

*Archives

The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Cell Death

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

*Infrared Rays

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 

Ischemia

Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

Angiotensin-Converting Enzyme Inhibitors

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Gadolinium DTPA

Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Adolescent

The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 

Suture Techniques

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 

Heart Rate

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Rats, Inbred WKY

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Data Interpretation, Statistical

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Arterial Occlusive Diseases

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 

Anticoagulants

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Aged

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 
Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

Quality Assurance, Health Care

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 

Functional Laterality

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 

Risk Factors

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)

No abstract available.

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 

Infarction, Middle Cerebral

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

Internationality

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Neuroprotective Agents

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 

Hydrogen-Ion Concentration

Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 

Cerebrovascular Disease

Approaches to Cerebrovascular Disease, Neurology Publications and Presentations (2006)

No abstract provided.

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)

No abstract available.

 

Disease Models, Animal

PDF

Animal models of focal brain ischemia (with Kenneth M. Sicard), Experimental and translational stroke medicine (2010)

Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology...

 

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

Link

Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)

This reference work covers every major methodology and disease model used in current neuroscience research....

 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)

No abstract available.

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 
Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Neurology Publications and Presentations (2003)

No abstract provided.

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 

Hypertension

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 

Tissue Plasminogen Activator

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 

Cerebrovascular Circulation

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Patients with acute stroke: recent developments in neuroimaging (with Pierre C. Combremont), Current atherosclerosis reports (2000)

The authors discuss recent developments in neuroimaging and their role in the evaluation of patients...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (with Gregory W. Albers), Neurology (1999)

Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 

Diffusion Magnetic Resonance Imaging

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Neurology Publications and Presentations (2003)

No abstract provided.

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 

Telemedicine

Link

Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

File

Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 

*Tomography, X-Ray Computed

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

*Ceramics

Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

Databases, Factual

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

*Microspheres

Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 

*Disease Models, Animal

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 

Sensation

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Reaction Time

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

*Cerebrovascular Circulation

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 

Brain Injuries

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Carbon Dioxide

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

*Research

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 

Thrombosis

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 
Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 
The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 

Benzenesulfonates

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

Manganese

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 

Cerebral Cortex

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 

Somatosensory Cortex

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Adult

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 

Rats, Sprague-Dawley

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 

Cluster Analysis

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

Reperfusion

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 

Motor Activity

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Biomedical Technology

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 

Dose-Response Relationship, Drug

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 

Intracranial Thrombosis

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Recovery of Function

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 

Laser Therapy, Low-Level

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 

Intracranial Embolism

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Patient Selection

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 

Cerebral Arteries

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Middle Cerebral Artery

Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 

Software

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 

Middle Aged

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 
Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 
Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

Neuromuscular Diseases

Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

Luminescent Measurements

A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 

Drug Approval

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

Kinetics

Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 

Aorta

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Antibodies, Antiphospholipid

Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Arnold-Chiari Malformation

Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 

Hernia

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Lipoproteins

Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

Radioligand Assay

Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 

Renal Dialysis

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Beta-Globulins

Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 

Succinate Dehydrogenase

Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 

Plasminogen Activators

Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 

Precipitin Tests

Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 

Constriction

Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 

Valine

The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Cholesterol

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 

Calcium Channel Blockers

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Linoleic Acid

Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 

Single-Blind Method

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 

Adrenergic beta-Antagonists

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 

Cerebral Angiography

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 

Pacemaker, Artificial

Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 

Fish Oils

Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 
The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

*Basilar Artery

Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 

Pyrimidines

Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 

gamma-Aminobutyric Acid

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Practice Guidelines as Topic

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 

Coronary Vessels

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Nootropic Agents

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 

Fatty Acids, Omega-3

Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 

Feasibility Studies

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 

Bradycardia

Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 

Propanolamines

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 

Blood-Brain Barrier

Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 

Hematoma

Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 

Astrocytes

Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Diabetes Mellitus, Type 1

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

*Thrombolytic Therapy

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 

Diet, Atherogenic

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Rupture, Spontaneous

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 

Myelin Proteins

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 

Intracranial Embolism and Thrombosis

Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 

Equipment Safety

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

Protein C Deficiency

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Safety

The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 

Vehicles

Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 

Dizocilpine Maleate

Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 

Veratridine

Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

Thiazoles

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Infusion Pumps

The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Interleukin-1

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 

Peptide Fragments

Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 

Administration, Oral

A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 

Staphylococcal Protein A

Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 

Magnesium

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

*Twins, Monozygotic

Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 

Sick Sinus Syndrome

Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 

Neutrophils

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 

Dietary Fats

Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 

Centrifugation, Density Gradient

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 

Brain Stem

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 

Coma

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Random Allocation

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 

Piperazines

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

Myxoma

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Radiographic Image Enhancement

Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 

Endarterectomy, Carotid

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 

Muscle Hypotonia

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Tachycardia, Paroxysmal

Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 

Herpesvirus 4, Human

Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 

Aorta, Thoracic

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 

Circadian Rhythm

Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Sensitivity and Specificity

The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 

Drug Synergism

Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 

Osmolar Concentration

A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 

Mitral Valve Prolapse

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 

Piperidines

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Sex Factors

Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 

*Myelitis

Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

Copper

A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 

Pyrrolidines

A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 

Cholic Acids

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Coronary Disease

The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Cell Size

Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Postoperative Complications

Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 

Free Radicals

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

*Brain Ischemia

Ischemic cerebral vascular disease: an overview, Arquivos de neuro-psiquiatria (1991)

The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer...

 

*Body Temperature

Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 

Heart Neoplasms

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Autoradiography

Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 

Nitrogen Oxides

Calcinosis

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Medication Errors

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Brain Diseases

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 

*Neurosyphilis

Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

Pharmaceutical Preparations

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

*Iatrogenic Disease

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Rabbits

Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Electroencephalography

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 

Blood Cells

n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 

Diltiazem

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Blood Platelet Disorders

Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Electrophoresis, Polyacrylamide Gel

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Partial Thromboplastin Time

Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 

Adenosine Kinase

Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 

Vasodilator Agents

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 

Brachial Artery

Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Postmortem Changes

Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

*Lipid Metabolism

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Transcription Factor AP-1

Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 

Heart Valve Prosthesis

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

*Sutures

Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 

Rats, Inbred Strains

Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 

Serologic Tests

Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 

Carotid Artery, Internal

Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 

Receptors, Glycine

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 

Disease Management

PDF

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 

Sample Size

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Christianity

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

Analysis of Variance

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 

*Stem Cell Transplantation

PDF

Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 

Heart Diseases

Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 

Models, Biological

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Body Weight

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Brain Chemistry

Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 

Paralysis

Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

Lung Neoplasms

Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 

Infusions, Intravenous

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Cod Liver Oil

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Staining and Labeling

Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 

Status Epilepticus

Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 

Fatty Acids, Unsaturated

n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 

Brain Neoplasms

Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 

Retrospective Studies

Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Antibodies

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Diabetic Ketoacidosis

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Extracellular Space

Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 

Stroke Volume

The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 

Legislation, Drug

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

GABA Agents

Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 

*Disease Management

Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 

Puerperal Disorders

Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 

Depression, Chemical

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

Microscopy, Electron

Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 

Hypercholesterolemia

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Electromyography

Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Platelet Factor 4

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 

Receptors, N-Methyl-D-Aspartate

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 

Myocardial Infarction

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 

Intracranial Arteriovenous Malformations

Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 

Neuropsychological Tests

Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

use

The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Lupus Coagulation Inhibitor

Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 

*Fibrinolytic Agents

Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 

Protein S Deficiency

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Mitral Valve Stenosis

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Clinical Trials, Phase III as Topic

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

Child

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Huntington Disease

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

*Meningitis

Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

beta-Thromboglobulin

Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 

*Tetrazolium Salts

Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 

*Blood Coagulation Factors

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Herpesviridae Infections

Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 

Coronary Artery Bypass

Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 

Growth Substances

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Monocytes

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 

Arteriosclerosis

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 
Atherosclerosis: cellular aspects and potential interventions, Cerebrovascular and brain metabolism reviews (1991)

The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This...

 
n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 
The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 

Propranolol

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

*Image Processing, Computer-Assisted

Link

Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 

Magnesium Sulfate

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 

Biological Availability

A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 

Spinal Cord Neoplasms

Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 

Radioimmunoassay

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Subtraction Technique

Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 

Atrial Fibrillation

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Oxidation-Reduction

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 

Necrosis

Link

Implications of Stroke Pathophysiology and the Ischemic Penumbra (with Rajat Kumar), Neurology Publications and Presentations (2009)

Published in: Bornstein NM (editor), Stroke: Practical Implications for Clinicians, Basel: Karger, 2009, p.24-36. ISBN...

 

PDF

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 

Thromboxane B2

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 

Thromboxanes

Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 

Internal Capsule

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 

Fatty Acids

Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

*Diet, Vegetarian

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

inhibitors

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

*Cell Death

Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 

Peripheral Nervous System Diseases

Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Product Surveillance, Postmarketing

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

Free Radical Scavengers

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 

Hypoglycemia

Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 

Spinal Cord

Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 

Syndrome

Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 

therapy

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Tomography, X-Ray Computed

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 
Patients with acute stroke: recent developments in neuroimaging (with Pierre C. Combremont), Current atherosclerosis reports (2000)

The authors discuss recent developments in neuroimaging and their role in the evaluation of patients...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 

Spectrum Analysis

Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 

Indans

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

Magnetic Resonance Spectroscopy

New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 

Intracellular Fluid

Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Cerebral Arterial Diseases

A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 

Prostheses and Implants

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Pedigree

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Combined Modality Therapy

Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Kainic Acid

Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 

*Blood Platelets

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Nerve Tissue Proteins

Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 

Hemorrhage

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 
The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 

Telangiectasia, Hereditary Hemorrhagic

Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

Cesarean Section

Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 

*Rats, Sprague-Dawley

A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 

Quinolines

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 

Lipoproteins, LDL

A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 

*Diet

The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

Receptors, Endothelin

A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 

*Hand

Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

Cell Adhesion Molecules

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Hyperlipidemias

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Arachidonic Acids

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Calmodulin

Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 

Blood Platelets

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 

Fatigue

Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Surgical Instruments

A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 

Blood Coagulation Factors

Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 

Link

Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 

Prostaglandins

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

Linear Models

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 

Echocardiography

Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 

Amantadine

Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

Hematologic Diseases

Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Hemodynamics

Ischemic cerebral vascular disease: an overview, Arquivos de neuro-psiquiatria (1991)

The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer...

 
Atherosclerosis: cellular aspects and potential interventions, Cerebrovascular and brain metabolism reviews (1991)

The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This...

 

Hypothermia

The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 

Motor Neurons

Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

Platelet Count

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

Fever

Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 

*Device Approval

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

Endarterectomy

The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 

Nifedipine

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 

*Blood Preservation

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Neurology

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Link

Introduction to advances in stroke 2009, Stroke; a journal of cerebral circulation (2010)
 

PDF

Advances in Stroke 2007: introduction, Stroke; a journal of cerebral circulation (2008)
 

Anemia, Sickle Cell

Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Urinary Plasminogen Activator

Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 

Quality of Health Care

Link

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

United States Food and Drug Administration

PDF

Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 

Cells, Cultured

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

Thermometers

Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 

Pregnatrienes

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 

Cardiovascular Agents

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Hemiplegia

Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 

Thiouracil

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Spreading Cortical Depression

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 

*Magnetic Resonance Spectroscopy

Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 

Swine

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 

Glioma

Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 

Parietal Lobe

Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 

Hydrogen Peroxide

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 

Antithrombin III Deficiency

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Linoleic Acids

Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 

Hypothalamus

Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 

Cell Compartmentation

Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Neuropil

Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Binding, Competitive

A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Glutamic Acid

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 

Evaluation Studies as Topic

Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 

Carcinoma, Small Cell

Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 

Fasting

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

Athetosis

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Respiratory Burst

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

*Subarachnoid Hemorrhage

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Animals, Newborn

Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 

Nimodipine

Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 

Dietary Fats, Unsaturated

n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 
Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 

Reference Values

The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 

Eicosapentaenoic Acid

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 

Placebos

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 

Endocarditis

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Lymphoma

Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 

*Cardiac Pacing, Artificial

Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 

Polycythemia Vera

Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 

Cell Adhesion

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Glycine

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 

Treatment Failure

Fibroblast Growth Factor 2

Pharmacological approaches to stroke recovery (with Seth P. Finklestein), Cerebrovascular diseases (Basel, Switzerland) (1999)
 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 

Diet

Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 

*Drug Design

Link

New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

Drug Evaluation, Preclinical

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

Cholesterol, LDL

Atherosclerosis: cellular aspects and potential interventions, Cerebrovascular and brain metabolism reviews (1991)

The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This...

 

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 

Sodium Chloride

Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 

Carotid Artery Thrombosis

Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 

Excitatory Amino Acid Antagonists

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 

Syringomyelia

Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 

N-Methylaspartate

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 

Immunoelectrophoresis

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Imidazoles

Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 

Lipids

Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 

Link

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 

*Electrocardiography

Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 

Arteriovenous Shunt, Surgical

Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Diagnosis, Differential

Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
Ischemic cerebral vascular disease: an overview, Arquivos de neuro-psiquiatria (1991)

The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer...

 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Antioxidants

Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

*Twins

Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 

*Fishes

The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

Drug Industry

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

PDF

Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 

Silicones

Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 

Guanidines

PDF

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 

Diuretics

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Body Water

Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 

Capillaries

Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 

Leukocytes, Mononuclear

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

Child, Preschool

Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 

Pregnancy

Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 

Biological Markers

Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 

Brain Abscess

Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 

Myelography

Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 

Synaptic Transmission

Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 

Acetamides

Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

Heart Defects, Congenital

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Postoperative Care

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Echo-Planar Imaging

Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 

Cardiomyopathy, Hypertrophic

Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 

Muscular Atrophy

Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 

*Platelet Factor 4

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 

Cell Count

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 

Leukocytes

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 

Carbazoles

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 

*Brachial Plexus

Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 

Lipid Peroxides

A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 

Pyridazines

A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 

Isoquinolines

Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

Platelet Aggregation

Link

The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 

Tissue Distribution

Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 

Cytidine Diphosphate Choline

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

PDF

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 

Injections, Intra-Arterial

Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 

Myelin Sheath

Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 

Apolipoproteins B

Link

Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 

Angioplasty, Transluminal, Percutaneous Coronary

Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 

Carotid Artery Diseases

The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 

Hypoxia-Ischemia, Brain

Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

Hydrocephalus

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 

Cytokines

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Seizures

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 

Ion Channels

Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 

Arrhythmias, Cardiac

Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 

Superoxides

Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 

*Free Radical Scavengers

Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 

Myocardial Reperfusion

Link

Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 

Histone Deacetylase Inhibitors

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

*Bias (Epidemiology)

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Cross-Sectional Studies

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

*Stroke

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Thromboembolism

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Transfection

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Guidelines as Topic

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Hospital Units

Link

Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

*Cardiovascular Diseases

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Kidney Failure, Chronic

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Cyclin-Dependent Kinase Inhibitor p21

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Magnetic Field Therapy

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Infusions, Intra-Arterial

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Obesity

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Diabetic Nephropathies

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Research Support as Topic

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Age Distribution

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Embryo, Mammalian

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Hospitals, University

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Health Care Sector

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Research

Link

Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

*Attitude of Health Personnel

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Laser-Doppler Flowmetry

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Electrocardiography

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Oxidative Stress

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Apoptosis

Link

Implications of Stroke Pathophysiology and the Ischemic Penumbra (with Rajat Kumar), Neurology Publications and Presentations (2009)

Published in: Bornstein NM (editor), Stroke: Practical Implications for Clinicians, Basel: Karger, 2009, p.24-36. ISBN...

 

Comprehension

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Green Fluorescent Proteins

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Equipment Design

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

*Brain Infarction

Link

Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

Europe

Link

European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

Hippocampus

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Hyperoxia

Link

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

Enzyme Inhibitors

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Granulocyte Colony-Stimulating Factor

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Link

Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

Incidence

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Drug Interactions

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Histone Deacetylases

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Gadolinium

Link

Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

Prevalence

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Conflict of Interest

Link

Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

Guideline Adherence

Cortical Spreading Depression

Link

Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

Internet

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Cell Cycle

Link

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 

Coronary Care Units

Link

Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

Diabetes Mellitus

Link

Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

Controlled Clinical Trials as Topic

Link

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

Clinical Trials, Phase II as Topic

Link

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

*Health Knowledge, Attitudes, Practice

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Thrombectomy

Link

Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

Warfarin

*Choice Behavior

Link

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

Infrared Rays

Link

Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

Technology

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Subarachnoid Hemorrhage

PDF

Cortical Vein Thrombosis as a Mimic for Isolated Cortical Subarachnoid Hemorrhage and Transient Ischemic Attack (with Jane G. Morris and Raphael A. Carandang), Case reports in neurology (2010)

Isolated cortical subarachnoid hemorrhage is rare and poorly understood. Differential diagnoses and proposed pathophysiology vary...

 

Case-Control Studies

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Health Care Surveys

Link

Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

Public Health

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

History, 21st Century

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Germany

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Cost-Benefit Analysis

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Foramen Ovale, Patent

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Blood Glucose

Link

Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

Cerebral Veins

PDF

Cortical Vein Thrombosis as a Mimic for Isolated Cortical Subarachnoid Hemorrhage and Transient Ischemic Attack (with Jane G. Morris and Raphael A. Carandang), Case reports in neurology (2010)

Isolated cortical subarachnoid hemorrhage is rare and poorly understood. Differential diagnoses and proposed pathophysiology vary...

 

effects

Link

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

Factor V Deficiency

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Health Education

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Xenon Isotopes

Link

MRI of stroke using hyperpolarized (129)Xe (with Xin Zhou, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, and Mitchell Albert), NMR in biomedicine (2010)

Because there is no background signal from xenon in biological tissue, and because inhaled xenon...

 

History, 20th Century

Link

Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

Thrombophilia

Link

Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

Xenon

Link

MRI of stroke using hyperpolarized (129)Xe (with Xin Zhou, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, and Mitchell Albert), NMR in biomedicine (2010)

Because there is no background signal from xenon in biological tissue, and because inhaled xenon...

 

No subject area

PDF

Warfarin Versus Warfarin and Aspirin in Atrial Fibrillation (with Gioacchino G. Curiale, Lucia Rivera Lara, and Anand Singla), Neurological Bulletin (2012)

Background—Anticoagulation with warfarin is an important therapy for preventing strokes in patients with atrial fibrillation...

 
Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat (with Nils Henninger, Kenneth M. Sicard, Zhixin Li, Praveen P. Kulkarni, Stephan Dutzmann, Christian Urbanek, and Stefan Schwab), Critical care medicine (2007)

OBJECTIVE: The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild...