*Algorithms

Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 

*Archives

The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

*Behavior, Animal

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

*Ceramics

Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

*Cerebrovascular Circulation

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

*Clinical Trials as Topic

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 

*Diagnostic Imaging

Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

*Diffusion Magnetic Resonance Imaging

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

*Disability Evaluation

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

*Disease Models, Animal

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

*Health Planning Guidelines

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 

*Hyperoxia

Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

*Infarction, Middle Cerebral Artery

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

*Infrared Rays

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 

*Magnetic Resonance Angiography

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

*Magnetic Resonance Imaging

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

*Microspheres

Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

*Models, Statistical

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

*Neuroprotective Agents

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

*Randomized Controlled Trials as Topic

The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

*Reperfusion

Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

*Research

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 

*Spreading Cortical Depression

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 

*Tomography, X-Ray Computed

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

*Treatment Outcome

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

Activities of Daily Living

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Acute Disease

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

Adolescent

The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Adult

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Aged

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Aged, 80 and over

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Algorithms

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

Alzheimer Disease

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Amyotrophic Lateral Sclerosis

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Angiotensin-Converting Enzyme Inhibitors

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Animals

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Anticoagulants

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Antihypertensive Agents

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Arterial Occlusive Diseases

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Artery

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

Aspirin

Automation

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Behavior, Animal

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Benzenesulfonates

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

Biomedical Technology

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 

Blood Pressure

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Body Temperature

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Boronic Acids

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Brain

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Brain Damage, Chronic

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Brain Edema

Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Brain Infarction

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Brain Injuries

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Brain Ischemia

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Brain Mapping

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Carbon Dioxide

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Cardiac Surgical Procedures

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

Cardiovascular Diseases

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

Carotid Artery, External

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

Caspase 1

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Cell Death

Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Cerebral Arteries

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 

Cerebral Cortex

Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 

Cerebral Hemorrhage

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Cerebral Infarction

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

Cerebrovascular Circulation

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Cerebrovascular Disease

Approaches to Cerebrovascular Disease, Neurology Publications and Presentations (2006)
No abstract provided.
 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)
No abstract available.
 

Cerebrovascular Disorders

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Circle of Willis

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

Clinical Trials as Topic

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 

Cluster Analysis

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

Coloring Agents

Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

Contrast Media

Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Data Interpretation, Statistical

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Databases, Factual

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Decision Making

Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 

Diagnostic Imaging

Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)
No abstract available.
 

Diffusion

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Diffusion Magnetic Resonance Imaging

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 

Dimethyl Sulfoxide

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Dipyridamole

Disease Models, Animal

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)
This reference work covers every major methodology and disease model used in current neuroscience research....
 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)
No abstract available.
 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Disease Progression

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Dose-Response Relationship, Drug

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Double-Blind Method

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Drug Administration Schedule

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Drug Combinations

Drug Design

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

Drug Therapy, Combination

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Embolism

Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 

Endpoint Determination

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

Expert Testimony

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Female

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Fibrinolytic Agents

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Follow-Up Studies

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Functional Laterality

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Gadolinium DTPA

Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Ganglia, Parasympathetic

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

Glycine Agents

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Heart Rate

Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Heparin

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Heparin, Low-Molecular-Weight

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Heptanoic Acids

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Humans

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

File

Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Hydrogen-Ion Concentration

Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 

Hydroxymethylglutaryl-CoA Reductase Inhibitors

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Hypercapnia

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Hypertension

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Image Processing, Computer-Assisted

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 

Indoles

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Infarction, Middle Cerebral

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

Infarction, Middle Cerebral Artery

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Inflammation

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Injections, Intravenous

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Internationality

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

Intracranial Aneurysm

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Intracranial Embolism

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Intracranial Thrombosis

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Ischemia

Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

Ischemic Attack,

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Ischemic Attack, Transient

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

Laser Therapy, Low-Level

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 

Ligation

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

Magnetic Resonance Angiography

Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Magnetic Resonance Imaging

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Male

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Manganese

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 

Meta-Analysis as Topic

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Microspheres

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Middle Aged

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Middle Cerebral Artery

Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 

Models, Animal

Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 

Motor Activity

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Movement Disorders

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Multiple Sclerosis

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Multivariate Analysis

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

National Institutes of Health (U.S.)

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Nerve Fibers

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 

Nerve Net

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Nervous System Diseases

Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)
This reference work covers every major methodology and disease model used in current neuroscience research....
 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)
No abstract available.
 

Neurodegenerative Diseases

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Neurons

Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Neuroprotective Agents

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Observer Variation

Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Odds Ratio

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Outcome Assessment (Health Care)

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Oxygen

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Oxygen Inhalation Therapy

Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

Parkinson Disease

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 

Patient Selection

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

Perceptual Disorders

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Perfusion

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Pilot Projects

Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Platelet Aggregation Inhibitors

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

Platelet Glycoprotein GPIIb-IIIa Complex

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Polyethylene

Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 

Potassium Chloride

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 

Primary Prevention

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Probability

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 

Prognosis

Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Prospective Studies

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

Proteasome Endopeptidase Complex

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Psychomotor Performance

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Pyrazines

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 

Pyrroles

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Quality Assurance, Health Care

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Quality of Life

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Randomized Controlled Trials as Topic

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Rats

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Rats, Inbred WKY

The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

Rats, Sprague-Dawley

Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Rats, Wistar

Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

Reaction Time

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

Recombinant Proteins

The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 

Recovery of Function

Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 

Recurrence

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Regional Blood Flow

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 

Regression Analysis

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 

Reperfusion

Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Reperfusion Injury

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 

Reproducibility of Results

Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Research Design

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

Risk

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Risk Assessment

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 

Risk Factors

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)
No abstract available.
 

Self-Evaluation Programs

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Sensation

Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 

Sensation Disorders

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Severity of Illness Index

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Silicon

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Simvastatin

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Software

Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 

Somatosensory Cortex

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 

Species Specificity

Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

Streptokinase

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Stroke

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

File

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 

File

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)
No abstract available.
 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

File

Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Surface Properties

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Survival Analysis

Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

Suture Techniques

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

Sutures

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 

Telemedicine

File

Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 

Tetrazolium Salts

Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

Therapeutics

Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Thrombolytic Therapy

Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 

Thrombosis

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

Ticlopidine

Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 

Time Factors

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 

Tissue Plasminogen Activator

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

Titanium

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 

Transient

Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 

Treatment Outcome

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 

United States

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 

Vascular Surgical Procedures

Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 

Venous Thrombosis

Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 

Virginia

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 

Water

Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

No subject area

Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat (with Nils Henninger, Kenneth M. Sicard, Zhixin Li, Praveen P. Kulkarni, Stephan Dutzmann, Christian Urbanek, and Stefan Schwab), Critical care medicine (2007)

OBJECTIVE: The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild...