Articles

Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat (with Nils Henninger, Kenneth M. Sicard, Zhixin Li, Praveen P. Kulkarni, Stephan Dutzmann, Christian Urbanek, and Stefan Schwab), Critical care medicine (2007)

OBJECTIVE: The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

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Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

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Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)
No abstract available.
 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)
No abstract available.
 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

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Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 

Books

Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)
This reference work covers every major methodology and disease model used in current neuroscience research....
 
Approaches to Cerebrovascular Disease, Neurology Publications and Presentations (2006)
No abstract provided.