Articles

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Warfarin Versus Warfarin and Aspirin in Atrial Fibrillation (with Gioacchino G. Curiale, Lucia Rivera Lara, and Anand Singla), Neurological Bulletin (2012)

Background—Anticoagulation with warfarin is an important therapy for preventing strokes in patients with atrial fibrillation...

 

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New approaches to neuroprotective drug development, Stroke; a journal of cerebral circulation (2011)

All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons...

 

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Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good (with Jane G. Morris and Swaraj Singh), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Despite a paucity of evidence supporting a true association of ischemic stroke...

 

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AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke (with Wolf-Rudiger Schabitz, Rico Laage, Gerhard Vogt, Winfried Koch, Rainer Kollmar, Stefan Schwab, Dietmar Schneider, Gerhard F. Hamann, Michael Rosenkranz, Roland Veltkamp, Jochen B. Fiebach, Werner Hacke, James C. Grotta, and Armin Schneider), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present...

 

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Acute ischemic stroke therapy (with Nils Henninger and Rajat Kumar), Expert review of cardiovascular therapy (2010)

Data from the European Cooperative Acute Stroke Study (ECASS) III trial demonstrated that tissue plasminogen...

 

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Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke (with Ramy El Khoury and Sean I. Savitz), Stroke; a journal of cerebral circulation (2010)

BACKGROUND AND PURPOSE: Clinical trials are assessing the efficacy of fibrinolysis in extended time windows...

 

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MRI of stroke using hyperpolarized (129)Xe (with Xin Zhou, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, and Mitchell Albert), NMR in biomedicine (2010)

Because there is no background signal from xenon in biological tissue, and because inhaled xenon...

 

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Cortical Vein Thrombosis as a Mimic for Isolated Cortical Subarachnoid Hemorrhage and Transient Ischemic Attack (with Jane G. Morris and Raphael A. Carandang), Case reports in neurology (2010)

Isolated cortical subarachnoid hemorrhage is rare and poorly understood. Differential diagnoses and proposed pathophysiology vary...

 

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Stroke: working toward a prioritized world agenda (with Vladimir Hachinski), International journal of stroke : official journal of the International Stroke Society (2010)

BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways...

 

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A New Era Begins, Stroke; a journal of cerebral circulation (2010)
 

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Animal models of focal brain ischemia (with Kenneth M. Sicard), Experimental and translational stroke medicine (2010)

Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology...

 

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Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL (with Bernt T. Bratane, Ronn P. Walvick, Claire Corot, and Eric Lancelot), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2009)

Perfusion imaging is crucial in imaging of ischemic stroke to determine 'tissue at risk' for...

 

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Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat (with Bernt T. Bratane, James P. Bouley, Armin Schneider, Birgül Bastan, and Nils Henninger), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Granulocyte-colony stimulating factor (G-CSF) is used clinically to attenuate neutropenia after chemotherapy....

 

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Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke (with Nils Henninger, Nabi Chowdhury, and Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2009)

The use of the only proven therapy for acute ischemic stroke, intravenous tissue plasminogen activator...

 

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Cardiac workup of ischemic stroke: can we improve our diagnostic yield (with Jane G. Morris and E. Jesus Duffis), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: Discovering potential cardiac sources of stroke is an important part of the...

 

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Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials (with Jeffrey L. Saver, Gregory W. Albers, Billy Dunn, and Karen C. Johnston), Stroke; a journal of cerebral circulation (2009)

The Stroke Therapy Academic Industry Roundtable (STAIR) meetings focus on helping to advance the development...

 

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Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps (with Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Nils Henninger), Brain research (2009)

Though diffusion weighted imaging (DWI) is frequently used for identifying the ischemic lesion in focal...

 

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European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy (with Vladimir Hachinski), Stroke; a journal of cerebral circulation (2009)
 

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Emerging drugs for acute ischemic stroke (with Kenneth M. Sicard), Expert opinion on emerging drugs (2009)

Stroke is no longer an untreatable condition, and its management is changing rapidly as new...

 

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Update of the stroke therapy academic industry roundtable preclinical recommendations (with Giora Z. Feuerstein, David W. Howells, Patricia D. Hurn, Thomas A. Kent, Sean I. Savitz, and Eng H. Lo), Stroke; a journal of cerebral circulation (2009)

The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to...

 

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Effectiveness and safety of transcranial laser therapy for acute ischemic stroke (with Justin A. Zivin, Gregory W. Albers, Natan Bornstein, Thomas Chippendale, Bjorn Dahlof, Thomas Devlin, Werner Hacke, William Holt, Sanja Ilic, Scott Kasner, Robert Lew, Marshall Nash, Julio Perez, Marilyn Rymer, Peter Schellinger, Dietmar Schneider, Stefan Schwab, Roland Veltkamp, Michael Walker, and Jackson Streeter), Stroke; a journal of cerebral circulation (2009)

BACKGROUND AND PURPOSE: We hypothesized that transcranial laser therapy (TLT) can use near-infrared laser technology...

 

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Implications of Stroke Pathophysiology and the Ischemic Penumbra (with Rajat Kumar), Neurology Publications and Presentations (2009)

Published in: Bornstein NM (editor), Stroke: Practical Implications for Clinicians, Basel: Karger, 2009, p.24-36. ISBN...

 

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Dilemmas in the management of atrial fibrillation in chronic kidney disease (with Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Hermann Pavenstädt, and Günter Breithardt), Journal of the American Society of Nephrology : JASN (2008)

Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality....

 

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Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials (with Maria Philip, Michael Benatar, and Sean I. Savitz), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: Numerous neuroprotective agents have proven effective in animal stroke studies, but every...

 

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Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke (with Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, and Meghan Shea), Experimental neurology (2008)

BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after...

 

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Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model (with Nils Henninger, Bernt T. Bratane, Birgül Bastan, and James P. Bouley), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2008)

In a rat embolic stroke (eMCAO) model, the effects of 100% normobaric hyperoxia (NBO) with...

 

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Treating acute ischemic stroke (with Birgül Bastan), Current opinion in drug discovery and development (2008)

Acute ischemic stroke (AIS) is a common disorder that has only one associated approved therapy:...

 

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Good laboratory practice: preventing introduction of bias at the bench (with Malcolm R. Macleod, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells), Stroke; a journal of cerebral circulation (2008)

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which...

 

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Stroke and TIA: epidemiology, risk factors, and the need for early intervention, The American journal of managed care (2008)

The risk of recurrent stroke in patients who have suffered a prior stroke or transient...

 

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Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices (with Sean I. Savitz, Michael Benatar, and Jeffrey L. Saver), Cerebrovascular diseases (Basel, Switzerland) (2008)

BACKGROUND: Thrombolysis remains the only proven therapy to benefit acute ischemic stroke (AIS) patients. Recent...

 

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Stroke (with Geoffrey A. Donnan, Malcolm R. Macleod, and Stephen M. Davis), Lancet (2008)

Stroke is the second most common cause of death and major cause of disability worldwide....

 

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Acute ischemic coronary artery disease and ischemic stroke: similarities and differences (with Edward Folland), American journal of therapeutics (2008)

Although acute myocardial infarction (MI) and acute ischemic stroke share similarities, physicians need to recognize...

 

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Advances in Stroke 2007: introduction, Stroke; a journal of cerebral circulation (2008)
 

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Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection (with Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan), The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of...

 
Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials (with Sean I. Savitz, Robert A. Lew, Erich Bluhmki, and Werner Hacke), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The SAINT I trial that showed a significant benefit of the neuroprotectant...

 
Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat (with Nils Henninger, Kenneth M. Sicard, Zhixin Li, Praveen P. Kulkarni, Stephan Dutzmann, Christian Urbanek, and Stefan Schwab), Critical care medicine (2007)

OBJECTIVE: The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild...

 
Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke (with Nils Henninger), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stimulation of the nerves traversing the ethmoidal foramen (including postsynaptic, parasympathetic projections...

 
Prophylactic neuroprotection (with Sean I. Savitz), Current drug targets (2007)

Ischemic brain injury can be anticipated in a number of clinical settings such as procedures...

 
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) (with Yair Lampl, Justin A. Zivin, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and...

 
The Virtual International Stroke Trials Archive (with Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human...

 

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Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials (with Sean I. Savitz), Annals of neurology (2007)

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk and...

 
Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats (with Nils Henninger and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Almost no data is available on the serial changes in the brain after spectacular shrinking...

 
Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2007)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effects of reperfusion...

 
Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats (with Nils Henninger, James P. Bouley, Julia M. Nelligan, and Kenneth M. Sicard), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2007)

Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia....

 

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Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials (with Nils Henninger), Current neurology and neuroscience reports (2007)

Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain...

 
Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes (with Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach), Stroke; a journal of cerebral circulation (2007)
 
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging (with James P. Bouley and Nils Henninger), Neuroscience letters (2006)

Differences among models in the temporal evolution of ischemia after middle cerebral artery occlusion (MCAO)...

 
Perspectives on neuroprotective stroke therapy (with Wolf-Rudiger Schabitz), Biochemical Society transactions (2006)

After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of...

 
Imaging in Experimental Neurology (with Eng H. Lo and Michael Lev), Neurology Publications and Presentations (2006)

No abstract available.

 
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (with Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong), Journal of neuroimmunology (2006)

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic...

 
Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical...

 
Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2006)

The numerous large-scale randomized clinical trials performed during the last decade on either unfractionated heparin,...

 
The ischemic penumbra: a new opportunity for neuroprotection, Cerebrovascular diseases (Basel, Switzerland) (2006)

The development of acute stroke therapies has yielded only limited success and many failures in...

 
Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging (with Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, and Juergen F. Bardutzky), Stroke; a journal of cerebral circulation (2006)

BACKGROUND AND PURPOSE: Differences among models in the temporal evolution of ischemia after middle cerebral...

 
Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats (with Kenneth M. Sicard, Nils Henninger, Timothy Q. Duong, and Craig F. Ferris), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2006)

The association between recovery of brain function and behavior after transient cerebral ischemia in animals...

 
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia (with Nils Henninger, Kenneth M. Sicard, James P. Bouley, and Nancy E. Stagliano), Neuroscience letters (2006)

The potential neuroprotective effects of VELCADE were investigated in two different models of focal cerebral...

 
Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI) (with Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Georg Bachmann, and Tibo Gerriets), Laboratory animals (2006)

Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. This study...

 
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Archives of neurology (2006)

The secondary prevention of ischemic stroke is aided by the use of antiplatelet therapy, and...

 
Identification and Treatment of Stroke Risk Factors, Neurology Publications and Presentations (2006)

No abstract available.

 
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy (with Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, and Ralph L. Sacco), Cerebrovascular diseases (Basel, Switzerland) (2005)

BACKGROUND AND PURPOSE: Gavestinel, GV150526, is a selective antagonist at the glycine site of the...

 

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Developing and implementing future stroke therapies: the potential of telemedicine, Annals of neurology (2005)

Stroke is a major public health concern with few positive phase III clinical trials and...

 

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Use of animal models has not contributed to development of acute stroke therapies: con (with Turgut Tatlisumak), Stroke; a journal of cerebral circulation (2005)
 
Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging (with Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, and Timothy Q. Duong), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Interstrain differences in the temporal evolution of ischemia after middle cerebral artery...

 

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Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (with Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler), Stroke; a journal of cerebral circulation (2005)

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug...

 
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome (with Majaz Moonis, Kevin Kane, Ute Schwiderski, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (2005)

BACKGROUND AND PURPOSE: Statins reduce the risk of stroke recurrence, but the benefits of statins...

 
Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution (with Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, and Timothy Q. Duong), Brain research (2005)

High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of...

 
Functional, perfusion and diffusion MRI of acute focal ischemic brain injury (with Qiang Shen, Hongxia Ren, Haiying Cheng, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Combined functional, perfusion and diffusion magnetic resonance imaging (MRI) with a temporal resolution of 30...

 
Thrombolytic therapy for acute ischemic stroke: 3 h and beyond (with Vasantha Padma and Majaz Moonis), Expert review of neurotherapeutics (2005)

The current status of thrombolytic therapy approved by the US Food and Drug Administration is...

 
Statistical prediction of tissue fate in acute ischemic brain injury (with Qiang Shen, Hongxia Ren, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

An algorithm was developed to statistically predict ischemic tissue fate on a pixel-by-pixel basis. Quantitative...

 
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging (with Erica C. Henning, Xiangjun Meng, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2005)

Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl...

 
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model (with Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, and Rajiv Ratan), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2005)

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant....

 

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Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke (with Anthony J. Furlan), Stroke; a journal of cerebral circulation (2005)
 
Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model (with Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, and Timothy Q. Duong), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Partial-volume effects (PVE) in stroke imaging could hinder proper delineation of normal, ischemic, and at-risk...

 
Antihypertensive medications for risk reduction of first and recurrent ischemic stroke (with Vasantha Padma and Majaz Moonis), Expert review of cardiovascular therapy (2004)

It is increasingly clear that even a small reduction in blood pressure results in a...

 

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The MATCH study results in the context of secondary stroke prevention (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data (with Qiang Shen, Hongxia Ren, James P. Bouley, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

High-resolution (200 x 200 x 1,500 microm3) imaging was performed to derive quantitative cerebral blood...

 
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Investigating focal cerebral ischemia requires animal models that are relevant to human...

 
Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke (with Timothy Q. Duong), Current atherosclerosis reports (2004)

The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The...

 
Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats (with Mark Kazemi, Matthew D. Silva, Fuhai Li, and Christopher H. Sotak), Magnetic resonance imaging (2004)

Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative...

 
Microsphere-induced embolic stroke: an MRI study (with Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Yoram Cohen, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2004)

Despite the many studies of the middle cerebral artery occlusion (MCAO) model, efficient therapy for...

 
Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging (with Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2004)

The effects of reperfusion on the spatiotemporal dynamics of transient (60 minutes) focal ischemic brain...

 
Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, and Georg Bachmann), Brain research. Brain research protocols (2004)

Magnetic resonance imaging (MRI) provides insights into the dynamics of focal cerebral ischemia. Usually, experimental...

 
Emerging therapies for cerebrovascular disorders (with Antonio Davalos), Stroke; a journal of cerebral circulation (2004)
 
Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia (with Xiangjun Meng, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong), Annals of neurology (2004)

Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke...

 
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2004)

BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an...

 
The ischemic penumbra: identification, evolution and treatment concepts, Cerebrovascular diseases (Basel, Switzerland) (2003)

The concept of the ischemic penumbra is an important one for both basic investigators of...

 
Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging (with Qiang Shen, Xiangjun Meng, Christopher H. Sotak, and Timothy Q. Duong), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2003)

Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion...

 
Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance (with Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, and Georg Bachmann), Stroke; a journal of cerebral circulation (2003)

BACKGROUND AND PURPOSE: Permanent middle cerebral artery occlusion (MCAO) with the use of the suture...

 

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Stem cell transplantation for stroke: does it work, and if so, how, Stroke; a journal of cerebral circulation (2003)
 
Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Neurology Publications and Presentations (2003)

No abstract provided.

 
Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Stroke; a journal of cerebral circulation (2003)

BACKGROUND: The development of acute stroke therapy has proven to be a daunting task, with...

 
Emerging therapies for acute ischemic stroke: new therapies on trial (with Thomas G. Brott), Stroke; a journal of cerebral circulation (2003)
 
The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats (with Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, and Christopher H. Sotak), Journal of neuroscience methods (2003)

BACKGROUND AND PURPOSE: The suture middle cerebral artery occlusion (MCAO) model is widely used for...

 
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia (with Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, and Fuhai Li), Brain research (2003)

NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and...

 
New perspectives on developing acute stroke therapy (with Rajiv Ratan), Annals of neurology (2003)

The development of additional acute stroke therapies to complement and supplement intravenous recombinant tissue-type plasminogen...

 
Combination Therapies, Restorative Therapies and Future Directions (with Majaz Moonis), Neurology Publications and Presentations (2003)

No abstract provided.

 
Imaging as a Surrogate Marker in Clinical Trials, Neurology Publications and Presentations (2003)

No abstract provided.

 
Neurovascular Disorders (with E. Orberk and M. Ramzan), Neurology Publications and Presentations (2003)

No abstract provided.

 
Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment, Neurology Publications and Presentations (2003)

No abstract provided.

 
Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain (with Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2002)

Selective intracellular (IC) and extracellular (EC) brain water apparent diffusion coefficient (ADC) values were measured...

 
Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke (with Majaz Moonis), Stroke; a journal of cerebral circulation (2002)

BACKGROUND AND PURPOSE: The utility of parenteral anticoagulation therapy in acute ischemic stroke has engendered...

 
Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, and Christopher H. Sotak), AJNR. American journal of neuroradiology (2002)

BACKGROUND AND PURPOSE: Initially decreased apparent diffusion coefficient (ADC) values are reversible if reperfusion is...

 
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia (with Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, and Joseph D. Fenstermacher), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The apparent diffusion coefficient of water (ADC) rapidly drops in ischemic tissue...

 
Imaging of acute stroke (with Majaz Moonis), Cerebrovascular diseases (Basel, Switzerland) (2001)

The utility of diagnostic imaging during the critical first few hours after stroke onset has...

 

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Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology (with Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Tsuyoshi Omae, Christopher H. Sotak, Joseph D. Fenstermacher, Chung Y. Hsu, and Weili Lin), Stroke; a journal of cerebral circulation (2001)

BACKGROUND AND PURPOSE: The early ischemic lesions demonstrated by diffusion-weighted imaging (DWI) are potentially reversible....

 
Patients with acute stroke: recent developments in neuroimaging (with Pierre C. Combremont), Current atherosclerosis reports (2000)

The authors discuss recent developments in neuroimaging and their role in the evaluation of patients...

 
An overview of acute stroke therapy: past, present, and future (with Wolf-Rudiger Schabitz), Archives of internal medicine (2000)
 
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, and Uwe Pschorn), Journal of the neurological sciences (2000)

Cation channels conduct calcium, sodium and potassium, cations that are likely deleterious in the evolution...

 
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats (with Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, and Christopher H. Sotak), Annals of neurology (2000)

This study was designed to characterize the initial and secondary changes of the apparent diffusion...

 

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The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats (with Wolf-Rudiger Schabitz and Fuhai Li), Stroke; a journal of cerebral circulation (2000)

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury...

 
Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI (with Fuhai Li, Matthew D. Silva, and Christopher H. Sotak), Neurology (2000)

OBJECTIVE: Ischemic lesions seen on diffusion-weighted imaging (DWI) are reversible if reperfusion is performed within...

 
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats (with Fuhai Li and Tsuyoshi Omae), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used...

 
Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Annals of neurology (1999)

Twenty-two rats were subjected to 8, 15, 30, or 60 minutes of temporary middle cerebral...

 
Pharmacological approaches to stroke recovery (with Seth P. Finklestein), Cerebrovascular diseases (Basel, Switzerland) (1999)
 
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke (with Gregory W. Albers), Neurology (1999)

Diffusion-weighted imaging (DWI) and perfusion imaging (PI) are two new magnetic resonance technologies that are...

 
Antithrombotic and thrombolytic therapy for ischemic stroke, Journal of thrombosis and thrombolysis (1999)

Anthithrombotic therapy is widely used as primary and secondary preventative treatment for ischemic cerebrovascular disease....

 

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Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia (with Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, and Kenneth W. Locke), Stroke; a journal of cerebral circulation (1999)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) and citicoline (cytidine 5'-diphosphate choline, an endogenous...

 
Determination of focal ischemic lesion volume in the rat brain using multispectral analysis (with Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, and Christopher H. Sotak), Journal of magnetic resonance imaging : JMRI (1998)

Multispectral (MS) analysis was used to determine the ischemic lesion volume in the rat brain...

 
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, and Alan C. Foster), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Brain ischemia is associated with a marked increase in extracellular adenosine levels....

 
A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging (with Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: In-bore middle cerebral artery occlusion (MCAO) enables investigators to acquire preischemic MRI...

 
Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging (with Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, and H. D. Kleinert), Neurology (1998)

OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and...

 
Further evolution toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1998)

The effective treatment of acute ischemic stroke remains an important goal of modern medicine and...

 
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study (with Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Endothelins (ETs) are potent vasoconstrictors. Plasma ET levels increase during acute brain...

 
Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats (with Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, and Daniel G. Gibson III), Journal of the neurological sciences (1998)

The best technical approach to rat middle cerebral artery occlusion (MCAO) using a nylon-monofilament suture...

 
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion (with Turgut Tatlisumak, Kentaro Takano, and Michael R. Meiler), Stroke; a journal of cerebral circulation (1998)

BACKGROUND AND PURPOSE: Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion...

 
Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model (with Fuhai Li, Katsumi Irie, and M. Sawkat Anwer), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1997)

Sixteen of 24 Sprague-Dawley rats with permanent middle cerebral artery occlusion for 24 hours were...

 
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies (with Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic...

 
Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats (with M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, and Bobby W. Sandage Jr.), Stroke; a journal of cerebral circulation (1997)

BACKGROUND AND PURPOSE: Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently...

 
Characterizing the target of acute stroke therapy, Stroke; a journal of cerebral circulation (1997)

BACKGROUND: The development of effective therapies for acute ischemic stroke presumes the existence of potentially...

 
Acute ischemic stroke therapy. A clinical overview (with M. Zulkuf Onal), European neurology (1997)

Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy...

 
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat (with Giora Z. Feuerstein, John J. Nunnari, and Robert R. Ruffolo Jr.), Pharmacology (1997)

The effects of carvedilol, a vasodilating beta-blocker with antioxidant activity, and nifedipine, a calcium channel...

 
Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging (with Turgut Tatlisumak, Kentaro Takano, and Richard A.D. Carano), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: Basic fibroblast growth factor (bFGF) has documented neuroprotective properties. This study was...

 
Hematologic disorders associated with ischemic stroke (with Turgut Tatlisumak), Journal of the neurological sciences (1996)

Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation...

 
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water (with Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1996)

BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of temporary...

 
Medical therapy for ischemic stroke (with Brian Silver and Johannes Weber), Clinical neuropharmacology (1996)

Therapy for stroke is undergoing major changes. Many of the changes parallel the advances made...

 
The role of spreading depression in focal ischemia evaluated by diffusion mapping (with Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, and Christopher H. Sotak), Annals of neurology (1996)

This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution...

 
Acute and atypical presentations of syringomyelia (with Ursula E. Anwer), European neurology (1996)

Syringomyelia is characterized by a longitudinal cavity or several cavities in the spinal cord, and...

 
Acute stroke treatment trials in the United States. Rethinking strategies for success (with Robert J. Adams, Anthony J. Furlan, and Gregory del Zoppo), Stroke; a journal of cerebral circulation (1995)

In this editorial, we present some of the important issues facing those who design and...

 
Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats (with Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells...

 
ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study (with Michael S. Pessin and Anthony J. Furian), JAMA : the journal of the American Medical Association (1995)
 
Diffusion and perfusion imaging for acute stroke, Surgical neurology (1995)
 
Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain (with Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, and Christopher H. Sotak), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1995)

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion...

 
Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model (with W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1995)

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset...

 
Potentially effective therapies for acute ischemic stroke, European neurology (1995)

Acute ischemic stroke remains without an effective therapy to improve outcome. As knowledge about the...

 
Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume (with Ronald A. Cohen and Yasuhiro Hasegawa), Neurological research (1994)

We used spectral electroencephalographic (EEG) analysis to demonstrate the physiological effect of focal brain ischaemia...

 
Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management (with John P. Weaver), Journal of the neurological sciences (1994)

Subarachnoid hemorrhage (SAH) remains a devastating neurological disorder, which most commonly develops after rupture of...

 
MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia (with Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak), Neurology (1994)

The reduction of the apparent diffusion coefficient (ADC) of water shortly after a focal ischemic...

 
Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain (with Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, and Christopher H. Sotak), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1994)

A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading...

 
The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke (with Yasuhiro Hasegawa, Bruce M. Baron, and Geoffrey Metcalf), Stroke; a journal of cerebral circulation (1994)

BACKGROUND AND PURPOSE: The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective...

 
Prophylactic neuroprotection for cerebral ischemia (with Saran Jonas and Ralph L. Sacco), Stroke; a journal of cerebral circulation (1994)

BACKGROUND: Treatments for acute ischemic stroke have evolved as knowledge about the pathophysiology of ischemic...

 
Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats (with Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, and Bernard J. Dardzinski), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (1994)

To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in...

 
Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats (with Kazuo Minematsu, Limin Li, and Christopher H. Sotak), Stroke; a journal of cerebral circulation (1993)

BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within...

 
Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A (with Gregory M. Plante and Elizabeth M. Doyle), Journal of the neurological sciences (1993)

Inflammatory cell-mediated myelin injury may be an important cause of tissue damage in both acute...

 
Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging (with Bernard J. Dardzinski, Christopher H. Sotak, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu), Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (1993)

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient...

 
Evolving toward effective therapy for acute ischemic stroke (with Julien Bogousslavsky), JAMA : the journal of the American Medical Association (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the...

 
Hypermagnesemic pseudocoma (with Marco A. Rizzo and J. Paul Lock), Archives of internal medicine (1993)

We treated a case of iatrogenic hypermagnesemia that clinically mimicked a central brain-stem herniation syndrome....

 
Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI (with Kazuo Minematsu, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak), Neurology (1993)

We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first...

 
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker (with John J. Nunnari and Stanley D. T. White), Experimental and molecular pathology (1992)

We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of...

 
Lacunar stroke: diagnosis, evaluation, and management (with Kazuo Minematsu), Heart disease and stroke : a journal for primary care physicians (1992)
 
Antithrombotic therapy for cerebrovascular disorders (with David G. Sherman, Mark L. Dyken, Michael Gent, Michael J. G. Harrison, and Robert G. Hart), Chest (1992)
 
Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis (with Scott H. Goodnight, John A. Cairns, and Garret A. FitzGerald), Chest (1992)
 
Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats (with Kazuo Minematsu, Limin Li, Christopher H. Sotak, and Michael A. Davis), Stroke; a journal of cerebral circulation (1992)

BACKGROUND AND PURPOSE: Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively display focal brain abnormalities within...

 
New magnetic resonance techniques for evaluating cerebrovascular disease (with Christopher H. Sotak, Kazuo Minematsu, and Limin Li), Annals of neurology (1992)

Magnetic resonance (MR) imaging of acute stroke has made important contributions to diagnosis. Several novel...

 
Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117 (with Margaret M. Arpano), Journal of the neurological sciences (1992)

Oxygen free radicals generated by leukocytes may contribute to tissue injury after central nervous system...

 
Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia (with Kazuo Minematsu, L. Li, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca), Neurology (1992)

We examined serial changes of diffusion- (DWI) and T2-weighted (T2WI) magnetic resonance images 30 minutes...

 
A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian), Atherosclerosis (1991)

Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages...

 
Ischemic cerebral vascular disease: an overview, Arquivos de neuro-psiquiatria (1991)

The management of patients with cerebrovascular ischemic disease (ICD) is rapidly changing due to newer...

 
Thrombosis in a congenitally bifurcated superior sagittal sinus (with Mark A. Hosley and James F. Lingley), Stroke; a journal of cerebral circulation (1991)

A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The...

 
A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls (with Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian), Neurology (1991)

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local...

 
Atherosclerosis: cellular aspects and potential interventions, Cerebrovascular and brain metabolism reviews (1991)

The pathogenesis of atherosclerosis has been extensively studied and the cellular aspects increasingly characterized. This...

 
A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes (with Peter H. Levine and Ronald A. Cohen), Stroke; a journal of cerebral circulation (1990)

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their...

 
Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model (with David A. Phillips, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang), Stroke; a journal of cerebral circulation (1990)

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are...

 
Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis (with Carlos S. Kase, Angela M. O'Neal, Gigi N. Girgis, and Joe I. Ordia), Annals of internal medicine (1990)

Tissue plasminogen activator (tPA), an approved coronary thrombolytic agent, can cause serious bleeding. We report...

 
Cardiogenic brain embolism and lupus anticoagulant (with Seymour M. Young, Ann Sigsbee, and Annmarie Errichetti), Annals of neurology (1989)

The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been...

 
n-3 fatty acids and cellular aspects of atherosclerosis (with Peter H. Levine and Alexander Leaf), Archives of internal medicine (1989)
 
Atherosclerosis: current concepts on pathogenesis and interventional therapies (with Frank M. Yatsu), Annals of neurology (1989)

Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus...

 
Amantadine treatment of fatigue associated with multiple sclerosis (with Ronald A. Cohen), Archives of neurology (1989)

Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment....

 

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Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis (with Peter H. Levine, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau), Archives of internal medicine (1989)

Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence...

 
The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model (with David A. Phillips, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang), Annals of neurology (1989)

Early fibrinolytic therapy with full molecular tissue plasminogen activator (t-PA) has been observed to be...

 
Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis (with Scott H. Goodnight, Garret A. FitzGerald, and Peter H. Levine), Chest (1989)
 
Brain tumor presenting as an acute pure motor hemiparesis (with Lawrence D. Recht), Stroke; a journal of cerebral circulation (1989)

Acute pure motor hemiparesis is a clinical syndrome of isolated hemiparesis usually related to lacunar...

 
Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit (with David A. Phillips and Michael A. Davis), AJNR. American journal of neuroradiology (1988)

We describe a model of thromboembolic stroke in rabbits that utilizes the Seldinger technique and...

 
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome (with Carlos S. Kase, Barbara Stelle, and Roger M. Mills Jr.), Stroke; a journal of cerebral circulation (1988)

The risk of embolic stroke during sick sinus syndrome before cardiac pacemaker insertion is substantial,...

 
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis (with Peter H. Levine, Bonnie H. Weiner, Christine H. Vaudreuil, Anita M. Natale, Mark H. Johnson, and James J. Hoogasian), Inflammation (1988)

Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active...

 
The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model (with David A. Phillips, Thomas W. Smith, and Michael A. Davis), Annals of neurology (1988)

Thrombolysis with tissue plasminogen activator (tPA) has been used to treat myocardial infarction and pulmonary...

 
Pure motor hemiplegia secondary to a saccular basilar artery aneurysm (with Thomas W. Smith and Richard Jacobs), Stroke; a journal of cerebral circulation (1988)

Pure motor hemiplegia is the most commonly encountered lacunar syndrome and is classically associated with...

 
Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients (with Mark H. Johnson, Anita M. Natale, and Peter H. Levine), Acta neurologica Scandinavica (1987)

We found a small but statistically significant reduction in the linoleic acid concentration of white...

 
The importance of carotid artery plaque disruption and hemorrhage (with Andrew M. Blumenfeld and Thomas W. Smith), Archives of neurology (1987)

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains...

 
Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis (with Lydia Wytrzes, Herbert G. Markley, and Howard J. Alfred), Neurology (1987)

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic...

 
Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential (with Katherine S. Upchurch, Peter H. Levine, Mark H. Johnson, Christine H. Vaudreuil, Anita M. Natale, and James J. Hoogasian), Inflammation (1986)

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of...

 
The potential clinical benefits of fish consumption (with Peter H. Levine and Bonnie H. Weiner), Archives of internal medicine (1986)
 

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Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model (with Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson), The New England journal of medicine (1986)

We studied the effect of cod-liver oil on the development and progression of coronary artery...

 

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The effect of vegetarian diets on plasma lipid and platelet levels (with Peter H. Levine, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Anita M. Natale, Christine H. Vaudreuil, and James J. Hoogasian), Archives of internal medicine (1986)

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This...

 
Unruptured intracranial aneurysm and transient focal cerebral ischemia: a follow-up study (with Monica M. Przelomski, Robin I. Davidson, H. Royden Jones, and Elliott M. Marcus), Neurology (1986)

Transient focal cerebral ischemia may occasionally be due to distal embolization of a clot from...

 
Cerebral embolism (with David G. Sherman, Mark L. Dyken, Michael J. G. Harrison, and Robert G. Hart), Chest (1986)
 
Tissue plasminogen activator reduces neurological damage after cerebral embolism (with Justin A. Zivin, Umberto DeGirolami, Carl C. Hemenway, and Joan A. Stashak), Science (New York, N.Y.) (1985)

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots...

 
Hypertensive encephalopathy: diffuse reversible white matter CT abnormalities (with Bernard Maister and Richard Jacobs), Annals of neurology (1985)
 
Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques (with James Russell, Justin A. Zivin, John L. Sullivan, and David A. Drachman), Archives of neurology (1985)

Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus...

 
Selective thromboxane inhibition: a new approach to antiplatelet therapy (with Bonnie H. Weiner, Ira S. Ockene, James S. Hoogasian, Anita M. Natale, John R. Arsenault, Mark H. Johnson, and Peter H. Levine), Stroke; a journal of cerebral circulation (1984)

Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the...

 
Hand muscle atrophy in multiple sclerosis (with Randall R. Long and David A. Drachman), Archives of neurology (1983)

The occurrence of muscular atrophy in multiple sclerosis (MS) has been considered unusual and classically...

 
Focal cerebral ischemia and mitral valve prolapse in monozygotic twins (with Edward Budnitz), Archives of internal medicine (1983)

Mitral valve prolapse (MVP) is a common frequently inherited cardiac valvular disorder. Ischemic cerebrovascular disease...

 
Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia (with Joseph L. Zito), Stroke; a journal of cerebral circulation (1983)

Neurologic complications in patients with Hereditary Hemorrhagic Telangiectasia (HHT) occur as a consequence of a...

 

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Platelet activation and mitral valve prolapse (with Bonnie H. Weiner, Ira S. Ockene, Ann D. Forsberg, Celeste P. Duffy, and Peter H. Levine), Neurology (1983)

Mitral valve prolapse (MVP) is a predisposing factor for cerebral ischemia, especially in young adults....

 
Marker proteins of platelet activation in patients with cerebrovascular disease (with Peter H. Levine, Albert L. Fullerton, Ann D. Forsberg, Celeste P. Duffy, James J. Hoogasian, and David A. Drachman), Archives of neurology (1982)

Platelet activation is assumed to occur in many patients with strokes of transient ischemic attacks...

 
Intramedullary spinal cord metastasis (with Peter R. Sebastian, Thomas W. Smith, and Robin I. Davidson), Surgical neurology (1981)

Intramedullary spinal cord metastases are rarely the presenting manifestation of a previously undiagnosed neoplasms. We...

 
Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease (with Peter H. Levine, Albert L. Fullerton, Celeste P. Duffy, and James J. Hoogasian), American journal of hematology (1981)

Platelet factor 4 (PF4), the platelet antiheparin protein, was isolated from both the supernatant and...

 
Bilateral cortical border-zone infarction. A pseudobrainstem stroke (with James B. McQuillen), Archives of neurology (1981)

Acute bilateral weakness of the extremities with weakness of the tongue classically signals a medullary...

 
Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms (with Robin I. Davidson and Elliott M. Marcus), Annals of neurology (1980)

Few reports have described an association between cerebral transient ischemic attacks (TIAs) and unruptured cerebral...

 
Familial inverted choreoathetosis (with Jane Sargent and David A. Drachman), Neurology (1979)

We present a family with infantile onset of progressive choreoathetosis. The movements affected the legs...

 
Holter monitoring in patients with transient focal cerebral ischemia, Stroke; a journal of cerebral circulation (1978)

The value of continuous long-term ECG monitoring in patients with transient generalized neurological symptoms is...

 
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature (with Gustavo Roman, Daniel P. Perl, and Charles M. Poser), Annals of neurology (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had...

 
Syphilitic meningomyelitis. A case report (with Charles M. Poser), Archives of neurology (1977)

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a...

 

Books

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Handbook of Clinical Neurology Volume 92, Stroke Part I: Basic and Epidemiological Aspects, Neurology Publications and Presentations (2009)

The first of three volumes on stroke in the Handbook of Clinical Neurology covering historical...

 

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Handbook of Clinical Neurology Volume 93, Stroke Part II: Clinical Manifestations and Pathogenesis, Neurology Publications and Presentations (2009)

The second of three volumes on stroke in the Handbook of Clinical Neurology series covering...

 

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Handbook of Clinical Neurology Volume 94, Stroke Part III: Investigation and Management, Neurology Publications and Presentations (2009)

The third of three volumes on stroke in the Handbook of Clinical Neurology series covering...

 

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Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)

This reference work covers every major methodology and disease model used in current neuroscience research....

 
Approaches to Cerebrovascular Disease, Neurology Publications and Presentations (2006)

No abstract provided.

 
Magnetic Resonance Imaging in Stroke (with Stephen Davis and Steven Warach), Neurology Publications and Presentations (2003)

Magnetic resonance imaging (MRI) provides non-invasive information about the brain's blood flow, water movement and...

 
Stroke Therapy (2nd ed.), Neurology Publications and Presentations (2001)

This second edition covers developments in the field regarding effective therapy for cerebrovascular disorders. It...

 
Current Review of Cerebrovascular Disease (4th ed.) (with Julien Bogousslavsky), Neurology Publications and Presentations (2000)

Advances in the field of cerebrovascular medicine occur at a rapid pace. The fourth edition...

 
Prevention of Ischemic Stroke (with Cesare Fieschi), Neurology Publications and Presentations (2000)

No abstract provided.

 
Current Review of Cerebrovascular Disease (3rd ed.) (with Julien Bogousslavsky), Neurology Publications and Presentations (1999)

No abstract provided.

 
Textbook of Neurology (with Julien Bogousslavsky), Neurology Publications and Presentations (1998)

No abstract provided.

 
Current Review of Cerebrovascular Disease (2nd ed.) (with Julien Bogousslavsky), Neurology Publications and Presentations (1996)

No abstract provided.

 
Stroke Therapy, Neurology Publications and Presentations (1995)

No abstract provided.

 
Clinical Atlas of Cerebrovascular Disorders, Neurology Publications and Presentations (1994)

No abstract available.

 
Current Review of Cerebrovascular Disease (with Julien Bogousslavsky), Neurology Publications and Presentations (1993)

No abstract provided.

 

Other

Link

Introduction to advances in stroke 2009, Stroke; a journal of cerebral circulation (2010)