Marc Fisher, MD, has a long track record in performing MRI-based experiments in rat stroke models to evaluate the presence and evolution of the ischemic penumbra. Using diffusion/perfusion MRI his experimental group has evaluated the effects of therapies on the progression of the diffusion/perfusion mismatch. Recently, they have shown that high-flow 100% oxygen therapy initiated early after embolic stroke in rats markedly inhibits the expansion of the ischemic core on diffusion imaging and extended the time window for successful reperfusion. Dr. Fisher has extensive experience in organizing and implementing clinical acute stroke therapy trials with a particular interest in imaging-based trials. He has performed these trials with co-investigators at multiple sites around the world. He has published extensively with over 230 peer-reviewed articles and has edited or co-edited 11 books. He currently serves as an associate editor of Stroke and will become the editor-in-chief in July 2010. He also serves as the principal organizer of the STAIR conferences.
Articles
Multi-modal approach for investigating brain and behavior changes in an animal model of traumatic brain injury (with Meghan E. Heffernan, Wei Huang, Kenneth M. Sicard, Bernt T. Bratane, Nanyin Zhang, Jean A. King, and Elif M. Sikoglu), Journal of neurotrauma (2013)
Utilization of novel approaches in imaging modalities are needed for enhancing diagnostic and therapeutic outcomes...
A call for transparent reporting to optimize the predictive value of preclinical research (with Story C. Landis), Nature (2012)
The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012...
Endovascular acute ischemic stroke therapy: applying basic science to clinical decisions, Neurology (2012)
Excerpt: The interface between basic science and clinical medicine is a key to an enhanced...
Identifying and utilizing the ischemic penumbra (with Birgul Bastan), Neurology (2012)
The penumbral concept is defined as different areas within the ischemic region evolve into irreversible...
International, multicenter randomized preclinical trials in translational stroke research: it's time to act (with Ulrich Dirnagl), Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2012)
Translational stroke research is in a crisis, and pharmaceutical companies continue to exit the field....
Books
Handbook of Clinical Neurology Volume 92, Stroke Part I: Basic and Epidemiological Aspects, Neurology Publications and Presentations (2009)
The first of three volumes on stroke in the Handbook of Clinical Neurology covering historical...
Handbook of Clinical Neurology Volume 93, Stroke Part II: Clinical Manifestations and Pathogenesis, Neurology Publications and Presentations (2009)
The second of three volumes on stroke in the Handbook of Clinical Neurology series covering...
Handbook of Clinical Neurology Volume 94, Stroke Part III: Investigation and Management, Neurology Publications and Presentations (2009)
The third of three volumes on stroke in the Handbook of Clinical Neurology series covering...
Handbook of Experimental Neurology: Methods and Techniques in Animal Research (with Turgut Tatlisumak), Neurology Publications and Presentations (2006)
This reference work covers every major methodology and disease model used in current neuroscience research....
Approaches to Cerebrovascular Disease, Neurology Publications and Presentations (2006)
No abstract provided.