Manju received her B.S. in Pharmaceutical Sciences from K.M.K. College, University
of Bombay, India in 1990. She completed her Ph.D. in 1996 in Biochemistry at The Ohio
State University. She did research on the bacteriophage T7 helicase mechanism, and was
mentored by Dr. Smita S. Patel. She then moved to The Rockefeller University as a
postdoctoral fellow to study E. coli clamp and clamp loader proteins that are essential
for DNA replication, and was mentored by Dr. Mike O’Donnell. In 2000, she became an
Assistant Professor of Molecular Biology and Biochemistry at Wesleyan University, where
she is currently an Associate Professor. Her research is focused on the workings of DNA
replication and DNA mismatch repair proteins from S. cerevisiae and T. aquaticus model
organisms.

Articles

Link

Model-based Global Analysis of Heterogeneous Experimental Data Using gfit, Methods in Molecular Biology (2009)

Regression analysis is indispensible for quantitative understanding of biological systems and for developing accurate computational...

 

PDF

Conserved residues in the delta subunit help the E. coli clamp loader, gamma complex, target primer-template DNA for clamp assembly, Nucleic Acids Research (2008)

The Escherichia coli clamp loader, gamma complex (gamma(3)deltadelta'lambdapsi), catalyzes ATP-driven assembly of beta clamps onto...

 

PDF

The effects of nucleotides on MutS-DNA binding kinetics clarify the role of MutS ATPase activity in mismatch repair, Journal of Molecular Biology (2007)

MutS protein initiates mismatch repair with recognition of a non-Watson-Crick base-pair or base insertion/deletion site...

 

PDF

Contribution of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiae Msh2–Msh6 mismatch repair protein, DNA Repair (2006)

Previous analyses of both Thermus aquaticus MutS homodimer and Saccharomyces cerevisiae Msh2–Msh6 heterodimer have revealed...

 

Unpublished Papers

Mechanism of Cadmium-Mediated Inhibition of Msh2-Msh6 Function in DNA Mismatch Repair, Division III Faculty Publications (2009)

The observation that Cadmium (Cd(2+)) inhibits Msh2-Msh6, which is responsible for identifying base pair mismatches...