Research interests: Synthesis of novel polymeric materials for medical and
pharmaceutical applications; surface modification of cationic polymers by the
complexation-interpenetration method to develop biocompatible materials; preparation and
characterization of polymeric membranes and microcapsules with controlled permeability
properties for medical and pharmaceutical applications; target-specific drug and vaccine
delivery systems for gastro-intestinal tract infections; localized delivery of cytotoxic
and antiangiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles;
intracellular delivery systems for drugs and genes using target-specific,
long-circulating, biodegradable polymeric nanoparticles; gold and iron-gold core-shell
nanoparticles for biosensing, imaging, and delivery applications. 

Articles

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Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer (with Lara Milane and Zhenfeng Duan), Bouvé Faculty Publications (2011)

The treatment of multi-drug resistant (MDR) cancer is a clinical challenge. Many MDR cells over-express...

 

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Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning (with Lara Milane and Zhenfeng Duan), Bouvé Faculty Publications (2011)

Background
The development of multi-drug resistant (MDR) cancer is a significant challenge in the clinical...

 

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Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis (with Luis A. Brito, Saradha Chandrasekhar, and Steven R. Little), Bouvé Faculty Publications (2010)

Background
In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy...

 

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Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Arun K. Iyer, Keinosuke Ryu, Edwin Choi, Francis J. Hornicek, Henry Mankin, Lara Milane, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

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Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma (with Michiro Susa, Arun K. Iyer, Keinosuke Ryu, Francis J. Hornicek, Henry Mankin, and Zhenfeng Duan), Bouvé Faculty Publications (2009)

Background: Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although...