Multiple Sclerosis

Investigation of the [-/A]8 and C1236T genetic variations within the human toll-like receptor 3 gene for association with multiple sclerosis (with Attila L. Szvetko, Ashleigh Jones, Jason Mackenzie, Peter A. Csurhes, Judith M. Greer, Michael Pender, and Lyn Griffiths), Neurological research (2010)

Multiple sclerosis (MS) is a serious cause of neurological disability among young adults. The clinical...

 

An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis (with A. S. Melllick, A. Tourtellotte, R. M. Nagra, and L. R. Griffiths), Brain research protocols (2005)

In our laboratory, we have developed methods in real-time detection and quantitative-polymerase chain reaction (Q-PCR)...

 

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Austrlaian population (with Micky Ovcaric, Rob Curtain, Matthew P. Johnson, Lyn R. Griffiths, Peter Csurhes, Michael P. Pender, and Rod A. Lea), Journal of neurogenetics (2005)

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS)...

 

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (with R. Curtain, R. A. Lea, S. Quinlan, C. Bellis, R. Hughes, J. MacMillan, and L. R. Griffiths), Journal of the neurological sciences (2004)

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important...

 

Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (with Virginie Martin, Micky Ovcaric, Rob P. Curtain, Rod A. Lea, Peter Csurhes, Michael P. Pender, and Lyn R. Griffiths), Brain research bulletin (2004)

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting...

 

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (with Linda Ferreira, Micky Ovcaric, Rob Curtain, Rod Lea, Peter Csurhes, Michael P. Pender, and Lyn R. Griffiths), Journal of the neurological sciences (2004)

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white...

 

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (with Albert S. Mellick, Kevin J. Ashton, Anthony E. G. Tannenberg, Rashed M. Nagra, Wallace W. Tourtellotte, and Lyn R. Griffiths), Molecular brain research (2003)

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and...

 

Migrane

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (with Robert Curtain, Rod Lea, John MacMillan, and Lyn Griffiths), European journal of medical genetics (2006)

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR)...

 

Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees (with R. P. Curtain, R. A. Lea, L. H. Haupt, M. Ovcaric, J. MacMillan, and L. R. Griffiths), Neurological research (2005)

Objectives: The aims of the study were: (i) to extend our linkage analysis of chromosome...

 

Hypertension

The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in caucasians (with S. Heux, F. Morin, R. A. Lea, M. Ovcaric, and L. R. Griffiths), Hypertension research (2004)

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes...

 

The role of adenosine-related genes variants in susceptibility to essential hypertension (with Kirsty Wright, Rod A. Lea, Micky Ovcaric, Stephanie Heux, Fabien Morin, Wallid Bey, John P. Headrick, and Lyn R. Griffiths), Journal of hypertension (2004)

Objective: To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine...

 

No subject area

Adrenoceptor function and expression in bladder urothelium and lamina propria (with Christian Moro and Russ Chess-Williams), Urology (2012)

Objective - To investigate the role of adrenoceptor subtypes in regulating the spontaneous contractile activity...

 

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Vasoactive neuropeptides in autoimmune diseases (with Ekua W. Brenu, Donald R. Staines, and Sonya M. Marshall-Gradisnik), Autoimmune disorders - Current concepts and advances from bedside to mechanistic insights (2011)

Extract:
Neuropeptides are a class of regulatory peptides with effects in nearly all physiological systems and...

 

Link

Mechanism of autoimmunity in pregnancy - The good and the bad (with Ekua W. Brenu, Donald R. Staines, and Sonya M. Marshall-Gradisnik), Autoimmune disorders - Pathogenetic aspects (2011)

Extract:
In humans, female’s humoral and cellular immunity are actually stronger than men (Nalbandian & Kovats,...

 

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Assessment of immune function after short-term administration of recombinant human growth hormone in healthy young males (with Sandra B. Ramos, Ekua W. Brenu, Rhys Christy, A. Bon Gray, Lars McNaughton, Mieke Van Driel, and Sonya M. Marshall-Gradisnik), European journal of applied physiology (2011)

Growth hormone (GH) is a commonly used drug aimed at improving sport performance. The aim...

 

Immunomodulators as therapeutic strategies for managing Multiple Sclerosis (with Ekua W. Brenu, Donald R. Staines, and Sonya Marshall-Gradisnik), Autoimmune disorders: Symptoms, diagnosis and treatment (2011)

Immunomodulation and immunosuppression are important strategies for monitoring autoimmune disorders. As imbalances in immune function...

 

Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population (with Jason Mackenzie, Attila Szvetko, Verena Weth, Julie Moreau, Judith M. Greer, Peter A. Csurhes, Michael P. Pender, and Lyn R. Griffiths), Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population (2009)

Objective: To examine a polymorphism within the 3′ untranslated region of the leukemia inhibitory factor...

 

An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population (with Attila L. Szvetko, Ashleigh Jones, Jason Mackenzie, Peter A. Csurhes, Judith M. Greer, Michael P. Pender, and Lyn R. Griffiths), Brain research (2009)

Multiple sclerosis (MS) is a common cause of neurological disability in young adults. The disease...

 

Gene expression studies in multiple sclerosis (with Francesca Fernandez and Lyn R. Griffiths), Current genomics (2007)

Bacterial alginate genes are chromosomal and fairly widespread among rRNA homology group I Pseudomonads and...

 

Allelic variation investigation of the estrogen receptor within an australian multiple sclerosis population (with Francesca Fernandez, Sophie Tajouri, Geraldine Detriche, Attila Szvetko, Natalie Colson, Peter Csurhes, Michael P. Pender, and Lyn R. Griffiths), Journal of the neurological sciences (2007)

Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to...

 

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort (with A. L. Szvetko, J. Fowdar, J. Nelson, N. Colson, P. A. Csurhes, M. P. Pender, and L. R. Griffiths), Journal of neurological sciences (2007)

Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS)...

 

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (with Virginie Martin, Claudia Gasparini, Micky Ovcaric, Rob Curtain, Rod A. Lea, Larisa M. Haupt, Peter Csurhes, Michael P. Pender, and Lyn R. Griffiths), Brain research bulletin (2006)

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation...